Daidzein hmoov CAS 486-66-8

1. Taw qhia
Daidzein yog ib qho isoflavone, ib hom phytoestrogen uas muaj nyob rau hauv ntau yam nroj tsuag, tshwj xeeb tshaj yog nyob rau hauv taum pauv thiab lwm yam legumes. Nws yog ib qho khoom siv ntuj tsim uas paub txog nws cov khoom antioxidant thiab tau pom tias muaj ntau yam txiaj ntsig kev noj qab haus huv, suav nrog txo kev pheej hmoo ntawm mob qog noj ntshav thiab kab mob plawv.

2. Lub luag haujlwm tseem ceeb

2.1. Antioxidant: Daidzein yog lub zog antioxidant uas tuaj yeem tiv thaiv cov hlwb los ntawm kev puas tsuaj los ntawm cov dawb radicals.
Daidzein hmoov muaj antioxidant muaj nuj nqi vim nws muaj peev xwm pub hydrogen ions los neutralize dawb radicals thiab tiv thaiv lawv los ntawm ua oxidative puas hlwb rau cov hlwb. Nov yog qee cov ntaub ntawv thiab kev sim uas txhawb nqa qhov no:
Hauv ib txoj kev tshawb fawb, cov kws tshawb fawb pom tias daidzein tuaj yeem txo qis oxidative kev nyuaj siab hauv daim siab hlwb kho nrog cov tshuaj lom los ntawm kev ua kom muaj zog ntawm cov enzymes antioxidant xws li superoxide dismutase (SOD) thiab glutathione peroxidase (GPx). Qhov no qhia tau hais tias daidzein tuaj yeem pab tiv thaiv cov hlwb los ntawm kev puas tsuaj oxidative los ntawm kev tswj cov tshuaj tiv thaiv antioxidant (Yin li al., 2017).
Lwm txoj kev tshawb fawb tau tshawb xyuas qhov cuam tshuam ntawm daidzein ntawm oxidative kev nyuaj siab thiab lipid peroxidation hauv nas. Cov txiaj ntsig tau pom tias kev kho mob daidzein txo qis qis ntawm malondialdehyde (MDA), ib qho cim ntawm lipid peroxidation, thiab nce qib ntawm cov enzymes antioxidant xws li SOD, catalase (CAT), thiab GPx hauv nas daim siab. Qhov no qhia tau hais tias daidzein tuaj yeem tiv thaiv oxidative kev nyuaj siab thiab lipid peroxidation hauv vivo (Song et al., 2010).
Kev tshuaj xyuas ntawm ntau yam kev tshawb fawb ntawm cov kua isoflavones, suav nrog daidzein, pom tias cov tebchaw no yog cov muaj zog antioxidants uas tuaj yeem tshem tawm cov dawb radicals thiab inhibit lipid peroxidation hauv vitro. Kev tshuaj xyuas kuj tau tshaj tawm tias cov kua isoflavones tuaj yeem ua rau cov tshuaj tua kab mob antioxidant thiab txo oxidative kev nyuaj siab hauv vivo (Messina li al., 2016).

2.2. Anti-inflammatory: Daidzein muaj cov tshuaj tiv thaiv kab mob uas tuaj yeem pab txo qhov mob thiab o hauv lub cev.
Daidzein hmoov muaj kev tiv thaiv kev ua haujlwm vim nws tuaj yeem txo qhov mob hauv lub cev. Kev mob tshwm sim tshwm sim thaum lub cev ua rau muaj teeb meem stimuli, xws li kab mob los yog raug mob los ntawm kev tso cov tshuaj hu ua cytokines uas ua rau o, mob, thiab liab. Thaum peb muaj mob ntau dhau mus ntev, nws tuaj yeem ua rau cov kab mob ntev xws li mob plawv thiab mob caj dab.
Daidzein tuaj yeem txo qhov mob los ntawm kev thaiv kev tsim cov cytokines uas ua rau mob, xws li qog necrosis factor alpha thiab interleukin -6. Nws ua haujlwm los ntawm kev txwv cov cytokines los ntawm kev tsim tawm thawj zaug, yog li lawv tsis tuaj yeem ua rau mob. Tsis tas li ntawd, nws tuaj yeem txo qhov tsim ntawm lwm yam tshuaj uas ua rau mob, xws li prostaglandins thiab nitric oxide.
Daidzein tuaj yeem hloov kho cov haujlwm ntawm lub cev tiv thaiv kab mob uas ua lub luag haujlwm tseem ceeb hauv kev mob. Nws tuaj yeem pab tswj kev ua haujlwm ntawm T hlwb thiab B hlwb uas koom nrog hauv lub cev tiv thaiv kab mob, ua rau muaj mob tsawg thiab muaj teeb meem tsawg.

2.3. Kev tswj hwm cov tshuaj hormones: Daidzein yog ib qho phytoestrogen uas tuaj yeem ua raws li cov tshuaj estrogen hauv lub cev, ua rau nws muaj txiaj ntsig zoo rau kev tswj cov tsos mob menopausal.
Daidzein yog tus tswj hwm cov tshuaj hormones vim tias nws tuaj yeem hloov kho cov tshuaj estrogen hauv lub cev. Daidzein yog cais raws li phytoestrogen, uas txhais tau hais tias nws tuaj yeem ua raws li cov teebmeem ntawm estrogen hauv lub cev. Nws tau pom tias muaj kev cuam tshuam nrog cov tshuaj estrogen receptors hauv tib neeg lub hlwb, ua rau muaj ntau yam lus teb.
Daidzein tuaj yeem ua tus agonist lossis antagonist ntawm estrogen nyob ntawm qhov xwm txheej. Piv txwv li, nyob rau hauv cov poj niam uas muaj cov tshuaj estrogen tsawg, daidzein tuaj yeem ua tus agonist los ntawm kev khi rau cov tshuaj estrogen receptor thiab txhawb cov tshuaj lom neeg zoo sib xws uas tsim los ntawm cov tshuaj estrogen. Hauv cov poj niam uas muaj cov tshuaj estrogen siab, daidzein tuaj yeem ua tus antagonist los ntawm kev khi rau tib lub receptor thiab sib tw nrog cov tshuaj estrogen rau kev khi, yog li ntawd, txo qis cov lus teb ntawm cov tshuaj estrogen.
Daidzein paub los hloov cov theem ntawm cov tshuaj hormones kev sib deev hauv tib neeg thiab tsiaj txhu, tshwj xeeb tshaj yog estrogen. Nws ua rau lub siab muaj peev xwm metabolize qee cov tshuaj hormones, ua rau txo qis tag nrho cov tshuaj estrogen hauv cov hlab ntsha. Qhov no cuam tshuam rau cov tshuaj hormones txuas rau kev ua poj niam cev xeeb tub tau ua rau muaj kev txaus siab rau lub peev xwm rau daidzein supplementation los txhawb kev noj qab haus huv tag nrho thiab txo qhov tshwm sim ntawm osteoporosis lossis estrogen ntsig txog qog noj ntshav.

2.4. Kev tiv thaiv kabmob kheesxaws: Cov kev tshawb fawb tau pom tias daidzein tuaj yeem pab tiv thaiv kev loj hlob ntawm qee hom qog nqaij hlav cancer, tshwj xeeb tshaj yog cov qog nqaij hlav mis thiab prostate.
Daidzein tuaj yeem pab tiv thaiv kabmob kheesxaws vim nws lub peev xwm los tiv thaiv kev loj hlob ntawm cov qog nqaij hlav qog noj ntshav thiab ua rau mob qog noj ntshav tuag, nrog rau nws cov tshuaj tiv thaiv antioxidant thiab tiv thaiv kab mob. Nov yog li cas:
a. Inhibition ntawm kev loj hlob ntawm cov qog nqaij hlav cancer: Daidzein tau pom tias inhibit qhov kev loj hlob thiab kev faib tawm ntawm cov qog nqaij hlav cancer hauv chav kuaj. Cov kev tshawb fawb tau pom tias daidzein tuaj yeem txo cov kev ua haujlwm ntawm cov enzymes koom nrog hauv kev loj hlob ntawm tes thiab kev loj hlob ntawm ntau cov qog nqaij hlav cancer, nrog rau cov qog nqaij hlav cancer mis thiab prostate (Zava li al., 1998, Chen et al., 2014).
b. Mob qog noj ntshav tuag (optosis): Daidzein tau pom los ua kom muaj kev ua haujlwm ntawm tes tuag, lossis apoptosis, hauv cov qog nqaij hlav cancer. Cov kev tshawb fawb tau pom tias daidzein tuaj yeem ua rau txoj hauv kev apoptotic hauv lub mis, prostate, thiab mob qog noj ntshav (Chen li al., 2014).
c. Antioxidant muaj nuj nqi: Daidzein muaj cov haujlwm antioxidant, lub ntsiab lus nws tuaj yeem tshem tawm cov dawb radicals thiab tiv thaiv cov hlwb los ntawm kev puas tsuaj oxidative. Dawb radicals yog cov molecules uas tuaj yeem ua rau cellular puas thiab ua rau qhov pib mob qog noj ntshav. Daidzein cov tshuaj antioxidant tuaj yeem pab tiv thaiv qhov kev puas tsuaj los ntawm qhov tshwm sim (Messina li al., 2016).
d. Anti-inflammatory muaj nuj nqi: Daidzein muaj cov tshuaj tiv thaiv kab mob thiab tuaj yeem pab txo qis qhov mob ntev uas ua rau muaj mob qog noj ntshav. Los ntawm kev txo qhov mob, daidzein tuaj yeem pab tiv thaiv kev tsim cov qog thiab txo qhov kev pheej hmoo ntawm mob qog noj ntshav (Chen li al., 2014).

3. Cov ntawv thov
Daidzein hmoov yog siv rau hauv cov khoom noj khoom haus, khoom noj khoom haus thiab dej haus, thiab cov khoom siv tshuaj pleev ib ce

4. Flow Chart
Defatting → Sib tsoo Extraction → Concentration → Purification → Kev rho tawm → Cov khoom tiav

5. Tus Qauv Zoo

6. Txoj kev tsom xam

MOA muaj nyob rau thaum thov.

7. Siv Chromatogram

8. Kev ruaj ntseg thiab kev nyab xeeb

Kev ruaj ntseg:
Nyob ruaj khov nyob rau hauv cov xwm txheej zoo (chav kub). Cov Ntaub Ntawv Kev ruaj ntseg muaj nyob rau ntawm koj qhov kev thov.
Kev nyab xeeb:
Raws li GARS (Feem ntau Pom Zoo Raws Li Kev Nyab Xeeb) Daim Ntawv Ceeb Toom ntawm Teb Chaws Asmeskas, nws muaj kev nyab xeeb rau tib neeg noj.

9. Cov neeg siv lus pom

10. Peb Daim Ntawv Pov Thawj

11.Peb cov neeg muas zaub

12. Exhibitions

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