Sodium L-ascorbyl -2-phosphate CAS 66170-10-3

1. Taw qhia
Sodium L-ascorbyl-2-phosphate yog vitamin C derivative ruaj khov nrog zoo solubility hauv dej txog li 64 feem pua, hauv glycerol txog li 13.2 feem pua, hauv propylene glycol txog li 1.6 feem pua ​​thiab tseem ceeb insoluble hauv ethanol, isopropyl myristate, cetyl stearate octanoate, caprylic acid triglyceride thiab C 12-15 alkyl benzoate.

2. Lub luag haujlwm tseem ceeb
2.1 Sodium ntsev ntawm ascorbyl phosphate rhuav tshem cov enzymes hauv daim tawv nqaij kom tso tawm cov vitamin C. Nws yog li ntawd muaj txiaj ntsig zoo antioxidant, tiv thaiv cov hlwb los ntawm kev puas tsuaj los ntawm cov dawb radicals.
Sodium ntsev ntawm ascorbyl phosphate yog dej soluble thiab tuaj yeem siv rau hauv cov kab dej hauv dej. Vitamin E acetate yog insoluble hauv dej thiab yuav tsum tau siv cov cab kuj. Txhawm rau ua kom yooj yim li sai tau, ethanol yog siv los ua tus nqa khoom. Vitamin E acetate tau yaj nyob rau hauv ib qho {{0}}.1 feem pua ​​​​ethanol tov thiab kev sim tswj kom ntseeg tau tias cov cab kuj (0.1 feem pua ​​​​ethanol tov hauv dej) tsis muaj kev cuam tshuam.
Vim qhov sib txawv kinetics ntawm kev hloov pauv ntawm cov tshuaj precursors mus rau hauv lub cev muaj zog, lub sij hawm zoo tshaj plaws yuav tsum tau txiav txim siab nyob rau hauv qhov kev sim thawj zaug. Lub sijhawm tshuaj tiv thaiv ntawm 7 hnub rau vitamin E acetate tom qab 48 teev rau ascorbyl phosphate sodium ntsev yog qhov zoo tagnrho (ntawm qhov taw tes qhov sib xyaw ua ke ruaj khov hauv dej). Nyob rau hauv cov ntaub ntawv ntawm kev ntsuam xyuas compounding, supplementation nrog vitamin E acetate yuav tsum tau pib 5 hnub ua ntej ntxiv ntawm sodium ascorbyl phosphate ntsev.
Cov txiaj ntsig
Tib neeg keratinised hlwb (HaCaT hlwb) tau ntxiv nrog cov vitamin E acetate (VEA) yaj hauv 0.1 feem pua ​​​​ethanol rau xya hnub thiab/los yog ascorbyl phosphate sodium ntsev (SAP) rau 48 teev. Cov concentrations hauv qab no tau kuaj tus kheej thiab ua ke nrog lwm cov khoom xyaw nquag.

Cov nyhuv ntawm antioxidants tau ntsuas nyob rau hauv kev txiav txim siab ntawm lub peev xwm los inhibit hydrogen peroxide-induced oxidation. Cells raug incubated nrog fluorophore-labeled DCFH. Kev ntxhov siab oxidative raug ntxias nrog 200 g molecules ntawm hydrogen peroxide (cov no yog qhov xav tau heev). Lub peev xwm antioxidant ntawm VEA thiab SAP tau txiav txim siab los ntawm kev ntsuas qhov tshwm sim fluorophores.

Cov txiaj ntsig
 

VEA ib leeg ntawm qhov concentration ntawm 300 micromolar inhibited oxidation los ntawm 10 feem pua.
Nrog 400 micromolar SAP ib leeg, oxidation tau inhibited los ntawm 14 feem pua.
Yog tias cov ntsiab lus saum toj no ntawm VEA thiab SAP tau siv ua ke, oxidation yog inhibited los ntawm ntau tshaj 30 feem pua.
Qhov no yog ib qho kev sib koom ua ke, vim tias ob qho tib si theoretically ntxiv txog li 24 feem pua.
Cov khoom antioxidant ntawm kev sib xyaw ua ke yog ntau dua li cov ntawm ib qho kev sib xyaw ib leeg, txawm tias siab dua li qhov theoretical sum.

Cov txiaj ntsig

Daim duab hauv qab no qhia cov txiaj ntsig rau ntau qhov sib xyaw ua ke.

Thawj kem qhia SAP ib leeg ntawm qhov sib txawv ntawm qhov sib txawv, cov txiaj ntsig ntawm kev txiav txim siab los ntawm koob tshuaj, raws li nws nce nrog concentration. Txawm li cas los xij, saturation tshwm sim los ntawm ib qho kev qhia tshwj xeeb mus ntxiv thiab nce qhov concentration tsis ua rau muaj txiaj ntsig ntau dua. Qhov tseeb yog tias 200 μmol / L muab cov txiaj ntsig siab tshaj plaws ntawm 18 feem pua, thaum lub concentration ntawm 400 μmol / L yog me ntsis qis thiab tsis overestimated. Qhov no yog cov npoo ntawm qhov yuam kev.

Kem 2 yog qhov kev xeem tswj. Cov hlwb nyob hauv ib puag ncig aqueous thiab sodium ascorbyl phosphate (SAP) yog soluble hauv dej thiab yog li tsis muaj teeb meem. Vitamin E acetate (VEA), ntawm qhov tod tes, yog cov roj soluble thiab yog li yuav tsum tau siv cov cab kuj. Cov cab kuj siv yog 0.1 feem pua ​​​​ethanol, uas yog ib qho yooj yim dispersion. Cov txiaj ntsig tau pom hauv kab ntawv no yog tib yam li cov nyob hauv thawj kab uas tsis muaj tus cab kuj (hauv cov npoo ntawm qhov yuam kev). Yog li ntawd, tsis muaj kev cuam tshuam ntawm tus cab kuj. Cov txiaj ntsig ntawm VEA hauv qhov kev sim no yog qhov ntseeg tau.

Kem 3-7 qhia cov txiaj ntsig rau VEA ib leeg thiab rau kev sim nrog VEA thiab SAP ua ke. cov txiaj ntsig rau VEA ib leeg yog xiav, ib txwm nyob rau hauv thawj kab ntawm ib pab pawg, nrog kev nce ntxiv mus rau sab xis, nrog rau cov txiaj ntsig zoo ib yam li SAP ib qho tab sis qis dua me ntsis hauv tus nqi, nrog kev nce siab ua rau muaj txiaj ntsig ntau dua tab sis nrog cov nyhuv saturating. Ntawm ib qho tshwj xeeb, kev nce concentration tsis ua rau muaj txiaj ntsig ntau dua. Qhov loj tshaj plaws yog 10 feem pua ​​inhibition.
Tag nrho lwm cov kab sawv cev ua ke ntawm SAP thiab VEA. Nws tuaj yeem pom tseeb tias cov txiaj ntsig siab dua tuaj yeem tau txais los ntawm kev sib xyaw ntawm SAP thiab VEA dua li nrog tus nqi ntawm ib qho khoom xyaw xwb.

2.2 Nws txhawb collagen ntau lawm thiab slows down ntawm daim tawv nqaij laus
Collagen yog ib qho protein uas muaj nyob hauv peb cov tawv nqaij uas muab kev txhawb nqa thiab qauv rau ntawm daim tawv nqaij. Nrog kev laus los yog raug UV hluav taws xob los yog dawb radicals, collagen ntau lawm txo, ua rau wrinkles, zoo kab, thiab sagging tawv nqaij.
Vitamin C sodium phosphate ua hauj lwm raws li ib tug haib antioxidant uas neutralizes dawb radicals, tiv thaiv daim tawv nqaij los ntawm ib puag ncig puas.
Tsis tas li ntawd, vitamin C sodium phosphate pab txo qis melanin ntau lawm, uas yog lub luag haujlwm rau hyperpigmentation, tsaus me ntsis, thiab cov tawv nqaij tsis sib xws.

2.3 Nws ua rau cov txheej txheem melanogenesis los tiv thaiv hyperpigmentation thiab actinic keratosis
ascorbic acid phosphate tau pom tias muaj cov tawv nqaij ua kom pom kev zoo thiab tuaj yeem tiv thaiv hyperpigmentation thiab actinic keratosis. Ntau qhov kev tshawb fawb tau tshawb xyuas qhov cuam tshuam ntawm AAP ntawm daim tawv nqaij pigmentation thiab kev puas tsuaj rau lub hnub.
Ib txoj kev tshawb fawb luam tawm nyob rau hauv Phau Tsom Faj Txog Kev Tshawb Fawb Kev Tshawb Fawb hauv xyoo 2010 tau pom tias kev siv tshuaj pleev ib ce AAP tuaj yeem tiv thaiv melanin synthesis hauv tib neeg cov hlwb melanocyte. Txoj kev tshawb no pom tau hais tias AAP txo qis kev tsim ntawm melanin los ntawm inhibiting kev ua ntawm tyrosinase, enzyme lub luag hauj lwm rau melanin synthesis. Cov kws tshawb fawb tau xaus lus tias AAP muaj peev xwm ua tus neeg saib xyuas tawv nqaij thiab tej zaum yuav pab tau rau kev tiv thaiv hyperpigmentation.
Lwm txoj kev tshawb fawb luam tawm nyob rau hauv Phau ntawv Journal of Drugs in Dermatology hauv xyoo 2014 tau tshawb xyuas qhov cuam tshuam ntawm AAP ntawm actinic keratosis, ib qho kab mob ntawm daim tawv nqaij uas feem ntau tshwm sim los ntawm lub hnub puas tsuaj. Cov kws tshawb fawb pom tias cov tshuaj pleev ib ce ntawm AAP ob zaug ib hnub rau 16 lub lis piam txo qhov hnyav ntawm actinic keratoses hauv cov neeg mob. Txoj kev tshawb no xaus lus tias AAP tej zaum yuav muaj kev nyab xeeb thiab kev kho mob zoo rau actinic keratosis, tejzaum nws vim nws cov tshuaj tiv thaiv antioxidant thiab tiv thaiv kab mob.
Hauv cov ntsiab lus, cov pov thawj kev sim muaj qhia tias Sodium L-ascorbyl-2-phosphate yuav pab tau rau kev tiv thaiv hyperpigmentation thiab actinic keratosis. Nws zoo nkaus li ua haujlwm los ntawm inhibiting melanin synthesis thiab los ntawm kev muab cov tshuaj tiv thaiv antioxidant thiab tiv thaiv kab mob ntawm daim tawv nqaij. Kev tshawb fawb ntxiv yog xav tau kom paub tseeb tias cov teebmeem no thiab tshawb xyuas qhov pom zoo thiab lub sijhawm ntawm kev kho mob rau cov mob no.

3. Cov ntawv thov
Sodium L-ascorbyl-2-phosphate tuaj yeem siv rau hauv ntau hom tshuaj pleev thaiv hnub, tshuaj tiv thaiv kab mob, tshuaj pleev lub cev, tshuaj pleev ib hnub thiab hmo ntuj thiab cov khoom ua kom tawv nqaij.
Pom zoo noj ntau npaum:
Kev tu tawv nqaij txhua hnub: 0.2 feem pua ​​~ 2 feem pua
Cov khoom tiv thaiv tshav ntuj: 0.2 feem pua ​​~ 1 feem pua
Whitening products: >3 feem pua

4. Flow Chart

Cov tshuaj tiv thaiv esterification ntawm vitamin C thiab aqueous sodium hydroxide tov yog catalyzed los ntawm enzymes tsim los ntawm cov kab mob, thiab tom qab ntawd kho kom tau sodium vitamin C phosphate.
Lub microbial synthesis ntawm vitamin C sodium phosphate muaj ob peb los ntawm cov khoom thiab tsis muaj kuab paug rau ib puag ncig.

5. Tus Qauv Zoo

Raws li Enterprise Standard

6. Txoj kev tsom xam

MOA muaj nyob rau thaum thov.

7. Reference Spectrum

8. Kev ruaj ntseg thiab kev nyab xeeb

Kev ruaj ntseg:

Nyob ruaj khov nyob rau hauv cov xwm txheej zoo (chav kub). Cov Ntaub Ntawv Kev ruaj ntseg muaj nyob rau ntawm koj qhov kev thov.
Kev nyab xeeb:

Raws li GARS (Feem ntau Pom Zoo Raws Li Kev Nyab Xeeb) Daim Ntawv Ceeb Toom ntawm Teb Chaws Asmeskas, nws muaj kev nyab xeeb rau tib neeg siv.

9. Cov neeg siv lus pom

10. Peb Daim Ntawv Pov Thawj

11. Peb Cov Neeg Siv Khoom

12. Exhibition

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