1. Taw qhia

Retinoic Acid Powder 302-79-4 yog cov khoom nruab nrab ntawm cov vitamin A metabolism. Vitamin An hloov mus rau hauv tretinaldehyde los ntawm kev tsim thiab metabolism ntawm cawv hauv vivo, thiab tom qab ntawd mus rau hauv tretinoin, tab sis tretinol thiab tretinoin tuaj yeem metabolize thiab sib hloov. Txawm li cas los xij, tretinoin tsis tuaj yeem txo qis rau hauv daim ntawv ntawm tretinaldehyde lossis cawv. Nws yog ib qho tshuaj siv ntau hauv kev kho mob dermatology, uas yog cov metabolic nruab nrab ntawm cov vitamin A (vitamin A) hauv lub cev, uas feem ntau cuam tshuam rau cov pob txha loj hlob thiab cov metabolism hauv epithelial, tuaj yeem txhawb kev loj hlob thiab rov ua dua tshiab ntawm cov hlwb epithelial, thiab tuaj yeem cuam tshuam kev loj hlob thiab Kev sib txawv ntawm keratinocytes, kom cov keratosis ntau dhau tuaj yeem rov qab mus rau qhov qub, yog li nws muaj qee yam kev kho mob ntawm ntau yam kab mob uas ua tiav keratosis, tsis tiav keratosis thiab hyperkeratosis Tshuaj, thiab tuaj yeem kho ntau yam kab mob ntawm daim tawv nqaij. Hauv zos smear nkag mus rau ntawm daim tawv nqaij sai sai thiab tuaj yeem ua kom rov ua dua tshiab ntawm cov hlwb epithelial. Cov tshuaj no tuaj yeem ua rau muaj zog thiab nrawm nrawm ntawm cov qog sebaceous thiab txo qis sebum secretion. Tsis tas li ntawd, cov khoom no kuj muaj cov teebmeem ntawm kev tiv thaiv qog, txhawb lub qhov txhab kho thiab tiv thaiv kab mob.

302-79-4

2. Muaj nuj nqi

2.1 Retinoic Acid Powder txhawb cov tawv nqaij metabolism, txhim kho roughness thiab dryness ntawm daim tawv nqaij, thiab ua rau cov tawv nqaij grey saib ci.

2.2 Txhim kho cov ntaub so ntswg ntawm daim tawv nqaij, txhim kho elasticity thiab pob tshab ntawm daim tawv nqaij, ua kom tawv nqaij zoo nkauj, dawb thiab noj qab haus huv.

2.3 Tshem tawm cov av uas nyob hauv qhov hws, txo qhov pores, thiab muaj cov kab mob tua kab mob. Kev xav ntawm cov tawv nqaij sib txawv tom qab siv cov khoom txhawb nqa uas muaj vitamin A acid kuj txawv.

Retinoic Acid Powder Functions

Topical Tretinoin (Retinoic Acid) Kev kho mob rau daim siab

3. Daim ntawv thov

3.1 Nws yog siv dav hauv kev lag luam tshuaj.

3.2 Retinoic Acid Powder 302-79-4 yog siv rau daim tawv nqaij keratinocytes-resistant tshuaj thiab cell-induced txawv tshuaj

Retinoic Acid Powder Applications

4. Specifications

Yam khoom

Specification

Cov txiaj ntsig kuaj

Kev piav qhia

Kev txheeb xyuas

Yellow crystalline hmoov

IR absorption spectrum yuav tsum sib haum nrog kev siv spectrum

Yellow crystalline hmoov sib haum

nrog kev siv spectrum

Yuav tsum nthuav tawm qhov siab tshaj plaws ntawm 352nm

Exhibits qhov siab tshaj plaws nqus ntawm

352nm ua

Poob rau ziab

Tsis ntau tshaj 0.5 feem pua

0.18 feem pua

Residue ntawm ignition

Tsis ntau tshaj 0.1 feem pua

0.05 feem pua

Cov hlau hnyav

Tsis ntau tshaj 0.002 feem pua

Tsawg dua 0.002 feem pua

Kev txwv ntawm Isotretinoin

Tsis ntau tshaj 5.0 feem pua

0.5 feem pua

Assay

98%.

99.95% ua

Xaus

Nws ua raws li tag nrho cov kev cai ntawm USP 34

5.Flow chart

6. Kev xeem

TSEEM CEEB

. TXOJ CAI

Piv txwv li: 100 mg / mL nyob rau hauv lub cev qhuav dej cawv

Spectrometric tej yam kev mob

(SaibUltraviolet- Pom tau Spectroscopy〈857〉 .)

Kev ntsuas wavelength: 440nm

Cell: 2 cm

Dawb: Dehydrated cawv

Kev tsom xam

Cov qauv:Qauv dawsthiabTsis muaj

Kev lees txais cov qauv: NMT 0.3

. OPTICAL ROTATION,Tshwj xeeb Kev sib hloov〈781S〉: plus 39.to plus 43. Sample solution: 5 mg/mL in methanol

. LOSS ON DRYING〈731〉: Qhuav ib qho qauv hauv lub tshuab nqus tsev ntawm 60. rau 2 h: nws poob NMT 0.5 feem pua ntawm nws qhov hnyav.

TSEEM CEEB

. PACKAGING THIAB STORAGE: Khaws rau hauv cov thawv nruj, thiab khaws cia hauv lub tub yees.

. LABELING: Daim ntawv lo qhia tias nws yog rau kev siv tsiaj xwb.

. USP REFERENCE STANDARDS 〈11〉 USP Trenbolone Acetate RS

USP Trenbolone Acetate System Suitability Mixture RS

Cov khoom xyaw uas muaj trenbolone thiab conjugated dihydro- trenbolone acetate nyob rau hauv ib tug matrix ntawm trenbolone acetate.

C20 H28O2

Retinoic acid;

tag nrho-trans-Retinoic acid [302-79-4].

DEFINITION

Tretinoin muaj NLT 97.

Tsis txhob raug lub teeb muaj zog, thiab siv cov iav qis-actinic-

ware nyob rau hauv kev ua tau zoo ntawm cov txheej txheem hauv qab no.

IDENTIFICATION

. A. INFRARED ABSORPTION 197M 〉

. B. ULTRAVIOLET ABSORPTION 〈197U〉 Analytical wavelength: 352 nm

Nruab nrab: Dilute 1 mL ntawm 0.01 N hydrochloric acid nrog isopropyl cawv rau 1000 mL.

Sample kua: 4 µg/mL inNruab nrab

Kev lees txais cov qauv: Absorptivities tsis txawv los ntawm ntau dua 3.0 feem pua, xam rau ntawm lub hauv paus qhuav.

QHIA

. txheej txheem

Qauv: 240 mg ntawm Tretinoin

Titrimetric system

Hom: Direct titration

Titrant: 0.1 N sodium methoxide VS

Endpoint detection: Visual

Kev tshuaj xyuas: Dissolve cov qauv hauv 50 mL ntawm dimethyl-formamide, thiab ntxiv 3 tee ntawm ib qho 1- hauv -100 daws ntawm thymol xiav hauv dimethylformamide. Titrate nrog Titrant mus rau qhov kawg ntsuab. Ua ib qho kev txiav txim siab dawb paug, thiab ua ib qho kev kho uas tsim nyog. Txhua mL ntawm 0.1 N sodium methoxide yog sib npaug rau 30.04 mg ntawm treti-noin (C20 H28O2).

Kev lees txais cov qauv: 97.0 feem pua – 103.0 feem pua ntawm lub hauv paus qhuav

IMPURITIES

. RESIDUE ON IGNITION〈281〉: NMT 0.1 feem pua

HEAVY METALS, Method II〈231〉: 20 ppm • (Official 1-Jan-2018)

Mobile theem: Isooctane, isopropyl cawv, thiab glacial acetic acid (99.65: 0.25: 0.1)

Kev tsim cov khoom tsim nyog: 250 µg / mL ntawm USP Tretinoin RS hauv isooctane npaj raws li hauv qab no. Dissolve ib tug ntau ntawm USP Tretinoin RS nyob rau hauv ib tug tsawg kawg nkaus tus nqi ntawm methylene chloride, thiab ntxiv ib tug tsim nyog tus nqi ntawm iso-octane mus rau lub paub concentration.

Cov txheej txheem kev daws teeb meem: 250 µg / mL ntawm USP Isotreti- noin RS hauv isooctane npaj raws li hauv qab no. Dissolve ib tug ntau ntawm USP Isotretinoin RS nyob rau hauv ib tug tsawg kawg nkaus tus nqi ntawm methylene chloride, thiab ntxiv ib tug haum npaum li cas ntawm isooctane mus rau lub paub concentration.

Kev daws teeb meem tsim nyog: Hloov 5 mL ntawm Standard Tshuag tov rau hauv 100-mL volumetric hwj, thiab ntxiv System suitability Tshuag tov rau ntim.

Standard tov: 12.5 µg / mL ntawm USP Isotretinoin RS hauv isooctane los ntawm Standard Tshuag tov

Cov qauv kev daws teeb meem: Hloov 25 mg ntawm Tretinoin mus rau hauv 100-mL volumetric hwj. Dissolve hauv qhov tsawg kawg nkaus ntawm methylene chloride, thiab ntxiv isooctane rau ntim.

7.NMR

Retinoic Acid NMR

8. Kev ruaj ntseg thiab kev nyab xeeb

Peb tau ua ntau yam kev ruaj ntseg thiab kev nyab xeeb kawm txog cov khoom no, raws li cov ntaub ntawv ceev ceev thiab kev ruaj ntseg mus sij hawm ntev, nws qhia cov yam ntxwv ruaj khov; raws li kev tshawb nrhiav tsiaj txhu, nws qhia tau tias muaj kev nyab xeeb.

9. Daim ntawv pov thawj

KONO ISO