Madecassoside hmoov CAS 18449-41-7

1. Taw qhia

Centella asiatica yog dav faib nyob rau hauv Tuam Tshoj thiab lwm qhov chaw ntawm lub ntiaj teb no thiab yog nplua nuj nyob rau hauv cov kev pab cuam. Vim nws txoj kev nyab xeeb, tsis muaj tshuaj lom, saj zoo thiab kho tau zoo, centella asiatica tau noj thiab siv tshuaj hauv ntau lub tebchaws rau ntau txhiab xyoo.

Lub ntsiab chemical Cheebtsam ntawm centella asiatica yog triterpenes, polyalkynes, flavonoids, thiab volatile roj, ntawm cov uas peb saponins Cheebtsam, asiaticoside, madecassoside, thiab cov triterpenoid acids, asiatic acid, madecassic acid yog lub ntsiab tshuaj monomer ntawm centella asiatica rau exert daim tawv nqaij. saib xyuas nyhuv. Nws muaj cov tshuaj pharmacological zoo. Vim muaj cov qauv sib txawv, cov teebmeem ntawm cov khoom no txawv me ntsis. Cov txiaj ntsig ntawm kev sim tau pom tias cov nyhuv inhibitory ntawm cov khoom ntawm centella asiatica extract ntawm kev loj hlob ntawm caws pliav-tsim hlwb yog nyob rau hauv kev txiav txim los ntawm muaj zog mus rau qaug zog: madecassolic acid> madecassic acid> madecassoside> asiaticoside.

Txawm li cas los xij, txij li madecassolic acid thiab madecassic acid pom cytotoxicity ntawm qhov kev sim qis qis, thiab madecassoside thiab asiaticoside tsis pom cytotoxicity ntawm qhov siab tshaj plaws yaj concentration, tsis muaj kev paub txog cytotoxic rau ntawm daim tawv nqaij. Tsis muaj kev paub txog toxicity los yog khaus rau ntawm daim tawv nqaij, thiab kev nyab xeeb yog zoo dua, yog li madecassoside thiab asiaticoside yog haum rau cov tawv nqaij rhiab heev. Tsis tas li ntawd, vim qhov sib txawv ntawm cov qauv ntawm madecassoside thiab asiaticoside, thawj tus yog ntau dua polar thiab ntau cov dej-soluble, yog li cov hmoov madecassoside tau kawm ntau dua thiab siv.

2. Lub luag haujlwm tseem ceeb

2.1 Lub luag haujlwm hauv kev kho cov tawv nqaij puas thiab kho qhov txhab

Hauv kev kho cov tawv nqaij puas tsuaj, fibroblasts ua lub luag haujlwm tseem ceeb, thiab kev hloov pauv hauv lawv cov cellular lom neeg tus cwj pwm txiav txim siab kho qhov kawg; collagen, raws li lub ntsiab tseem ceeb ntawm extracellular matrix, kuj plays lub luag haujlwm tseem ceeb hauv kev kho daim tawv nqaij. Ntau qhov kev sim hauv vitro, kev sim tsiaj, thiab kev sim tib neeg tau lees paub tias ua cassoside nyob rau hauv ntau qhov concentration tuaj yeem txhawb kev loj hlob ntawm tib neeg fibroblasts, txhawb cov synthesis ntawm collagen secreted rau sab nraud ntawm cov hlwb, txhawb nqa proline, sulfuric acid Biosynthesis ntawm chondroitin. thiab heparan sulfate, nce collagen thiab mucopolysaccharide cov ntsiab lus, txhim kho epithelialization, thiab ua kom lub zog tensile ntawm daim tawv nqaij. Txawm hais tias nws yog rau cov qhov txhab dav lossis qhov txhab qeeb, nws muaj txiaj ntsig zoo los txhawb kev kho mob.

2.2 Kho cov nyhuv ntawm hypertrophic caws pliav

Madecassoside tuaj yeem tiv thaiv thiab kho hypertrophic nti, thiab yog siv dav hauv cov caws pliav thiab keloids los ntawm ntau qhov txhab, kub hnyiab, pob txuv, yas thiab phais kom zoo nkauj. Lub hauv paus ntsiab lus yog tsuas yog inhibit qhov kev loj hlob ntawm fibroblasts hauv kev tsim caws pliav thiab txo cov ntaub so ntswg granulation. , ntxiv rau kev tiv thaiv caws pliav los ntawm kev txo collagen synthesis thiab txo cov extracellular matrix.

Ib txoj kev tshawb fawb tib neeg ntawm centella asiatica noj qhov ncauj ua ke nrog kev siv sab nraud hauv kev kho mob kub hnyiab tau pom tias madecassoside tuaj yeem tiv thaiv thiab kho cov caws pliav hyperplasia los ntawm inhibiting ntau infiltration ntawm T lymphocytes thiab macrophages nyob rau hauv kub-hom caws pliav ntaub so ntswg thiab cuam tshuam rau lawv txoj kev sib deev; Nws tseem tuaj yeem txhawb nqa apoptosis ntawm caws pliav-tsim hlwb txhawb kev txo qis ntawm cov kab mob hauv lub cev, vascular occlusion, thiab loosening ntawm collagen fibers, ua rau tag nrho cov caws pliav nqaij mos thiab me, ua rau degenerative lesions.

2.3 Cov nyhuv ntawm kev kho cov tawv nqaij pigmentation thiab depigmentation

Madecassoside tshuaj pleev tuaj yeem kho tom qab mob hyperpigmentation, UV-induced tawv nqaij hyperpigmentation, thiab vitiligo repigmentation.

Cov kev sim qhia tau hais tias madecassoside tuaj yeem ua ncaj qha rau melanocytes thiab inhibit melanin synthesis. Vim tias nws tsis muaj cytotoxicity, nws tuaj yeem siv los ua tus neeg saib xyuas kev nyab xeeb ntawm daim tawv nqaij. Madecassoside tuaj yeem cuam tshuam qhov mob tshwm sim los ntawm ultraviolet rays. Nws tuaj yeem txo qhov kev qhia ntawm cov kab mob inflammatory los inhibit synthesis ntawm melanin thiab thaiv kev tso tawm ntawm melanin stimulating yam los ntawm stratum corneum, yog li nws tuaj yeem siv los tiv thaiv hyperpigmentation ntawm tib neeg cov tawv nqaij los ntawm ultraviolet rays. Thaum tib neeg melanocytes raug puas tsuaj los ntawm oxidative kev nyuaj siab, madecassoside tuaj yeem ua lub luag haujlwm antioxidant los ntawm kev ua haujlwm ntawm autophagy, tiv thaiv thiab txhawb kev kho cov melanocytes, yog li nws tuaj yeem kho vitiligo los ntawm oxidative kev nyuaj siab thiab ua kom rov zoo. xim nyhuv. Ib txoj kev tshawb fawb hauv tsev tau pom tias nyob rau hauv qhov kev txhawb nqa ntawm tsuas yog hydrogen peroxide, tus naj npawb ntawm melanocyte dendrites tau txo qis lossis txawm tias kuaj tom qab 300 feeb, thaum nyob ntawm qhov ntau ntawm 10, 50, thiab 100 ug / mL madecassoside tiv thaiv. Cov dendrites tsuas yog me ntsis retracted, thiab tus nqi retraction tau qeeb qeeb. Cov txiaj ntsig tau pom tias ua cov hmoov nplej tau txo qis qhov kev hloov pauv ntawm dendrites ntawm melanocytes nyob rau hauv oxidative kev nyuaj siab thiab thaiv qhov shortening ntawm dendrites.

3. Cov ntawv thov

Madecassoside hmoov yog siv nyob rau hauv cov tshuaj pleev ib ce thiab tshuaj industries.

4. Flow daim ntawv qhia

Centella asiatica → Ethanol reflux → Concentration nyob rau hauv txo siab → Purification ntawm macroporous adsorption resin → Concentration nyob rau hauv txo siab → Decolorization nrog activated carbon → Preparative chromatography → Concentration thiab ziab → Madecassoside

5. Cov qauv zoo

6. Txoj Kev Xeem

MOA muaj nyob rau thaum thov.

7. Reference Spectrum

8. Kev ruaj ntseg thiab kev nyab xeeb

Kev ruaj ntseg:
Nyob ruaj khov nyob rau hauv cov xwm txheej zoo (chav kub). Cov Ntaub Ntawv Kev ruaj ntseg muaj nyob rau ntawm koj qhov kev thov.
Kev nyab xeeb:
Raws li GARS (Feem ntau Pom Zoo Raws Li Kev Nyab Xeeb) Daim Ntawv Ceeb Toom ntawm Teb Chaws Asmeskas, nws muaj kev nyab xeeb rau tib neeg siv.

9. Cov neeg siv lus pom

10.Peb Daim Ntawv Pov Thawj

11.Peb cov neeg muas zaub

12. Exhibitions

Cim npe nrov: Madecassoside hmoov cas 18449-41-7, manufacturers, lwm tus neeg, Hoobkas, lag luam wholesale, yuav, nqe, zoo tshaj plaws, tej, kev muag khoom