Acacetin hmoov 480-44-4

1. Taw qhia

Acacetin hmoov yog muab los ntawm acacetin, uas yog lub ntuj flavonoid uas muaj dav nyob rau hauv cov xwm, xws li cov ntoo acacia, artichoke, dav hlau nyom, mimosa, chrysanthemum, thiab lwm yam. Acacetin tseem hu ua 5, 7-dihydroxy{{ 2}}'-methoxyflavone. Ntxiv rau nws cov tshuaj antidepressant thiab tranquilizing teebmeem, nws muaj ntau yam kev ua ub no, xws li antioxidant, anti-inflammatory thiab antibacterial, thiab anti-viral, thiab tuaj yeem kho ntau yam kab mob hauv ntau txoj kev.

2. Lub luag haujlwm tseem ceeb

2.1. Muaj zog tiv thaiv oxidation nyhuv

Acacetin tuaj yeem txhim kho kev ua haujlwm ntawm glutathione peroxidase thiab catalase hauv nas daim siab homogenate thiab glutathione peroxidase kev ua haujlwm hauv cov ntshav thiab cov ntshav hauv qee qhov concentration ntau, thiab nws muaj cov txiaj ntsig tseem ceeb ntawm DPPH radicals hauv ntau qhov sib txawv, uas tuaj yeem txo qis lipid peroxidation. cov tshuaj tiv thaiv hauv vitro, uas, rau qee qhov, kuj qhia txog nws daim ntawv thov hauv kev kho mob ntawm daim siab, kab mob neurodegenerative thiab ncua kev laus.

2.2. Antitumor cuam tshuam

2.2.1. Inhibition ntawm receptors thiab transcription yam. Cov theem qhia ntawm qog necrosis yam thiab apoptotic factor receptors yog ib qho tseem ceeb tshaj plaws cuam tshuam rau apoptosis ntawm cov qog hlwb. Thaum TRAIL-R1 thiab TRAIL-R2 receptors tau qhia hauv RAW264.7 macrophages, nws tau pom tias RAW264.7 macrophages nthuav tawm cov lus qhia ntawm TRAIL-R1 receptor, thiab acacetin tuaj yeem cuam tshuam qhov qhia theem ntawm TRAIL-R1 tuag receptor hauv macrophages.

2.2.2. Acacetin tuaj yeem cuam tshuam kev ua haujlwm ntawm tib neeg cov tshuaj metabolizing enzyme CYP1B1 enzyme thiab cuam tshuam kev tsim cov tshuaj estrogenic carcinogenic metabolites, yog li tiv thaiv qog nqaij hlav. acacetin muaj zog inhibitory ua haujlwm tiv thaiv estrogenic carcinogenic metabolites nrog IC50 ntawm (1.43 ± 0.27)µmol-L rau estradiol-based CYP1B1 enzyme kev ua.

2.2.3 Inhibition ntawm proliferation ntawm cov qog nqaij hlav cancer

Acacetin tau pom tias muaj kev cuam tshuam loj rau tib neeg cov qog nqaij hlav qog noj ntshav (LOVO hlwb), tib neeg cov qog nqaij hlav cancer mis (MCF-7 hlwb) thiab osteogenic sarcoma hlwb (U2-OS hlwb) los ntawm MTT kev soj ntsuam nrog ib koob tshuaj cuam tshuam. Nws qhia tau hais tias Acacetin inhibits kev loj hlob ntawm cov qog hlwb thiab muaj kev tiv thaiv qog.

2.2.4. Kev cai ntawm kev taw qhia txoj kev

Acacetin-induced apoptosis nyob rau hauv tus nplaig squamous carcinoma cell kab (HSC-3) tau pom tias yog tus yam ntxwv ntawm DNA fragmentation thiab nce nyob rau hauv sub-G1 theem hlwb, ua kom cov caspase -3 thiab PARP txoj kev. acacetin ua rau txo qis hauv Bcl-2 qhia, nce hauv Bax: Bcl-2 piv, txo qis hauv mitochondrial membrane peev xwm, thiab ua kom cov mitogen-activated protein kinases (MAPKs). Yog li, acacetin-induced apoptosis nyob rau hauv lingual squamous carcinoma cell kab yog ze ze rau nws lub peev xwm los qhib MAPKs-tswj txoj kev taw qhia.

2.2.5. Anti-tumor migration effect

Mob ntsws cancer yog ib qho mob qog noj ntshav ntau tshaj plaws hauv ntiaj teb thiab nws cov kab mob metastasis yog qhov ua rau tuag rau cov neeg mob qog noj ntshav. Acacetin cuam tshuam rau kev ntxeem tau thiab kev tsiv teb tsaws ntawm tib neeg uas tsis yog me me ntawm lub ntsws cancer A549 hlwb thiab nthuav tawm cov nyhuv inhibitory ntawm qog cell adhesion, morphology / actin cytoskeletal kev npaj, ntxeem tau thiab tsiv teb tsaws.

2.2.6. Pro-apoptotic nyhuv

Qhov induction ntawm apoptosis los ntawm acacetin tej zaum yuav yog ib qho tseem ceeb mechanism rau nws cov nyhuv antitumor.

2.3. Bacteriostatic nyhuv

Staphylococcus aureus yog ib qho tseem ceeb hauv tsev kho mob thiab cov kab mob hauv zej zog. Kev tawm tsam thoob plaws ntawm S. aureus ua rau muaj kev hem thawj rau tib neeg thiab tsiaj noj qab haus huv. Inhibitors ntawm toxicity tuaj yeem kho tus kab mob S. aureus thiab tsis cuam tshuam rau kev loj hlob ntawm cov kab mob thiab tsis tseem ceeb ua rau cov kab mob tsis zoo. Cov qauv kab mob tsiaj tau pom tias acacetin inhibits kev ua haujlwm ntawm SrtA gene hauv S. aureus, ua kom pom tias acacetin tiv thaiv lub raum abscess tsim nyob rau hauv nas thiab txhim kho kev ciaj sia. Qhov no qhia tau hais tias acacetin muaj qee cov tshuaj tua kab mob.

2.4. Anti-osteoporosis nyhuv

Osteoporosis yog ib qho ntawm cov kab mob orthopedic tshaj plaws thiab acacetin muaj cov tshuaj tiv thaiv osteoporotic. Nyob rau hauv lub qub osteoblast cell kab MC3T3-E1 hlwb, acacetin txhawb kev loj hlob thiab kev sib txawv ntawm osteoblasts, nce qib ntawm runt-related transcription factor 2 (Runx2), osteocalcin (OCN), osteopontin (OPN) thiab collagen hom. Kuv (COLI) mRNA, thiab qhib lub AKT signaling txoj kev.

2.5. Cov teebmeem Cardioprotective

Cov neeg mob uas muaj ischemic cardiomyopathy tshwm sim los ntawm ischemia / reperfusion raug mob muaj qhov mob hnyav heev thiab tuag taus. Intravenous tswj ntawm dej-soluble acacetin precursors tau pom los txo cov ventricular arrhythmia cov qhab nia thiab lub sij hawm kam rau ua, txo ventricular fibrillation thiab infarct loj, thiab ua tau zoo tshem tawm kev sim atrial fibrillation nyob rau hauv beagle dev yam tsis tau nce lub ECG QTc ncua sij hawm nyob rau hauv ib qho in vitro nas qauv ntawm lub zos ischemia. /reperfusion.

2.6. Immunomodulatory thiab anti-inflammatory teebmeem

Acacetin plays lub luag haujlwm tseem ceeb hauv cov kab mob autoimmune kho mob. Nws tau raug pom tias acacetin txo qhov tam sim no ntawm Kv1.3, cuam tshuam qhov kev qhia ntawm Kv1.3 protein ntau thiab tseem inhibits qhov kev nkag mus ntawm Ca2 ntxiv, uas ua rau kom cov khoom tsim tawm ntawm IL-2 los ntawm kev ua kom muaj kev ua haujlwm ntawm cov khoom hloov pauv. NFAT1, NF-κB thiab p65/p50. Hauv IL -2 kev zais cia, me me cuam tshuam RNAs tawm tsam Kv1.3 txo cov nyhuv inhibitory ntawm acacetin. Yog li, acacetin thaiv txoj hauv kev Kv1.3 thiab inhibits kev ua haujlwm ntawm tib neeg T hlwb, uas muaj txiaj ntsig zoo rau nws cov tshuaj tiv thaiv kab mob thiab tiv thaiv kab mob.

2.7. Cov teebmeem Neuroprotective

Acacetin tiv thaiv dopamine neurons muab los ntawm Parkinson tus kab mob neurotoxicity los ntawm nws cov tshuaj tiv thaiv kab mob. Hauv LPS-induced neuroinflammatory BV-2 hlwb thiab tsiaj cov qauv ntawm neuroinflammation thiab ischemia, acacetin cuam tshuam qhov tso tawm ntawm NO thiab prostaglandin E(2), thiab kev qhia ntawm inducible nitric oxide synthase thiab cyclooxygenase-2 hauv LPS-induced BV-2 hlwb. acacetin kuj txo cov pro-inflammatory cytokines, qog necrosis factor-, IL-1, thiab inhibited cov kev ua ntawm nuclear transcription factor NF-κB thiab p38 mitogen-activated protein kinase. Kev ua haujlwm ntawm p38 mitogen-activated protein kinase.

3. Cov ntawv thov

Acacetin hmoov yog siv rau hauv cov khoom siv tshuaj pleev ib ce thiab kev kho mob, nws muaj peev xwm zoo hauv kev lag luam tshuaj.

4. Flow Chart

5. Tus Qauv Zoo

Raws li Enterprise Standard

6. Txoj kev tsom xam

MOA muaj nyob rau thaum thov.

7. Reference Spectrum

8. Kev ruaj ntseg thiab kev nyab xeeb

Kev ruaj ntseg:

Nyob ruaj khov nyob rau hauv cov xwm txheej zoo (chav kub). Cov Ntaub Ntawv Kev ruaj ntseg muaj nyob rau ntawm koj qhov kev thov.
Kev nyab xeeb:

Raws li GARS (Feem ntau Pom Zoo Raws Li Kev Nyab Xeeb) Daim Ntawv Ceeb Toom ntawm Teb Chaws Asmeskas, nws muaj kev nyab xeeb rau tib neeg siv.

9. Cov neeg siv lus pom

10. Peb Daim Ntawv Pov Thawj

11. Peb Cov Neeg Siv Khoom

12. Exhibition

Cim npe nrov: Acacetin hmoov 480-44-4, manufacturers, lwm tus neeg, Hoobkas, lag luam wholesale, yuav, nqe, zoo tshaj plaws, tej, kev muag khoom