L-Rhamnose Monohydrate CAS

1. Taw qhia
L-Rhamnose monohydrate, tseem hu ua 6-deoxy-L-mannose, yog ib yam ntawm 6-deoxyhexoses nrog Murray's qab zib, yog 33 feem pua ​​​​qab zib li sucrose thiab yog ib yam khoom dav pom hauv cov nroj tsuag polysaccharides, glycosides, cog cov pos hniav thiab kab mob polysaccharides. Nws tuaj yeem siv los txiav txim siab txoj hnyuv permeability, tuaj yeem siv los ua cov khoom qab zib, thiab tseem tuaj yeem siv los tsim cov tsw thiab cov tshuaj tsw qab, uas muaj kev nyab xeeb thiab noj tau.

2. Lub luag haujlwm tseem ceeb
Ua kom epidermal thickness thiab txhim kho daim tawv nqaij morphology
Nyob rau hauv ib qho in vitro reconstructed daim tawv nqaij histology xyaum ua tej yam, lub epidermal thickness ntawm cov qauv kho nrog 5 feem pua ​​​​rhamnose yog ho nce.

Daim duab 1 Hauv vitro reconstructed daim tawv nqaij histology ntawm papillary fibroblasts cais los ntawm cov hluas (A, B) los yog laus (C, D) pub. Tswj (A, C) thiab 5 mM rhamnose kho cov qauv (B, D) (n=3 rau txhua tus mob). Qhov tseem ceeb, cov kab mob epidermal nce ntxiv hauv cov qauv kho rhamnose (B, D), raws li qhia hauv daim duab sib txuas (E). Mann-Whitney nonparametric test tau siv thiab * P<0.05 indicates significant results.

Daim duab 2 Histology ntawm tib neeg cov tawv nqaij (55 xyoo) tom qab siv tshuaj pleev ib ce txhua hnub ntawm 5 feem pua ​​​​rhamnose rau 8 lub lis piam. Kev tswj tsis tau kho (A), cov placebo-kho (B), thiab rhamnose kho cov qauv (C). Ntawm qhov kev ceeb toom, cov kab ntawv sib txuas rau txhua tus neeg pub dawb qhia (n=20) (D) qhov tseem ceeb ntawm cov kab mob epidermal thickness rau cov qauv kho rhamnose (C). bar=100 μm, *P<0.05.

2.2 Txhawb collagen ntau lawm thiab txhim kho daim tawv nqaij laus
Lub network collagen hauv daim tawv nqaij laus yog cuam tshuam los ntawm kev txo qis hauv collagen synthesis vim fibroblast aging raws li pov thawj los ntawm kev txo qis hauv hom I precollagen hauv dermal fibroblasts hauv vitro. Tsis tas li ntawd, hom IV collagen, lwm yam tseem ceeb ntawm dermal-epidermal hlws ris, yog hnub nyoog-nyob ntawm seb cov tawv nqaij ntawm tib neeg los yog kab lis kev cai fibroblasts.

L-Rhamnose Monohydrate muaj peev xwm ua kom muaj txiaj ntsig zoo hauv lub cev (hauv vitro thiab hauv vivo) ntawm papillary dermal thiab dermal-epidermal hlws ris qauv, txhawb kev tso tawm ntawm cov khoom siv hauv qab daus thiab hom IV collagen deposition thiab hom I procollagen ntau lawm, yog li pab txhawb kev txhim kho ntawm tawv nqaij laus.

Daim duab 3 Immunostaining ntawm daim tawv nqaij hom IV collagen (A, B, C) thiab procollagen (E, F, G) nyob rau hauv cov neeg tau txais (55 xyoo) tom qab tshuaj pleev ib ce ntawm rhamnose. Cov qauv tsis kho (A, E), placebo (B, F) thiab cov qauv kho (C, G). Qhov sib npaug ntawm cov kab mob immunostaining bar graphs rau txhua tus neeg pub dawb (n=20) hauv (D) thiab (H). Staining rau ob hom IV collagen thiab hom I procollagen tau nce hauv rhamnose kho tawv nqaij (C, G). Nco ntsoov qhov staining ntawm cov hlab ntsha hauv qab daus. bar =100 μm, *P<0.05.

Daim duab 4 Immunostaining ntawm hom I procollagen (A) thiab hom I collagen (B) hauv tib neeg daim tawv nqaij. Nws yog ib qho tseem ceeb uas hom I procollagen staining yog txwv rau thaj tsam papillary dermal, whereas hom I collagen staining sib haum rau tag nrho cov dermis nyob rau hauv tag nrho. bar=100 μm.

Daim duab 5 Immunostaining ntawm collagen IV, hauv qab daus membrane proteoglycans, thiab procollagen nyob rau hauv reconstructed daim tawv nqaij nrog cov hluas (23 xyoo) (A, B, F, G, K, L) los yog cov laus pub (63 xyoo) (C, D, H , I, M, B, G, L, I, N) lossis A, F, K, C, 5, H, M). Immunostaining rau collagen IV (E), hauv qab daus membrane proteoglycan (J), thiab procollagen (O). Qhov tseem ceeb, qhov staining yog khaus ntau dua hauv cov qauv kho rhamnose piv rau cov qauv tsis kho. Mann-Whitney nonparametric test tau siv thiab * P<0.05 indicates significant results.

2.3 Anti-inflammatory teebmeem
L-rhamnose thiab d-mannose muaj cov qauv zoo sib xws thiab zoo li yuav raug lees paub thiab khi los ntawm OnRBL-L. Yog li, L-rhamnose tuaj yeem ua lub cim qhia suab thaj thiab khi rau rhamnose-specific binding lectins (RBSLs), yog li ua kom muaj ntau yam kev tiv thaiv kab mob, uas tuaj yeem cuam tshuam thiab tswj ntau yam kev qhia thiab kev qhia, yog li ua rau lub cev tiv thaiv kab mob. nyhuv.

3. Cov ntawv thov
L-Rhamnose Monohydrate tuaj yeem siv los txiav txim siab txoj hnyuv permeability, ua cov khoom qab zib, thiab rau kev tsim cov tsw thiab cov tshuaj tsw qab. Nws tuaj yeem siv tsis tau tsuas yog raws li kev kuaj mob reagent, tab sis kuj yog cov khoom noj ntxiv hauv kev ua cov kas fes qib siab, dej haus, qhob cij, khoom noj nqaij thiab lwm yam. Tam sim no, rhamnose tau siv dav hauv kev tsim khoom thiab kev tshawb fawb tshawb fawb.

4. Flow Chart
Rutin → hydrolysis → filtration → filtrate → neutralization → decolorization → fermentation → pom → concentration → crystallization → rhamnose

5. Tus Qauv Zoo

Raws li Enterprise Standard

6. Txoj kev tsom xam

MOA muaj nyob rau thaum thov.

7. Reference Spectrum

8. Kev ruaj ntseg thiab kev nyab xeeb

Kev ruaj ntseg:

Nyob ruaj khov nyob rau hauv cov xwm txheej zoo (chav kub). Cov Ntaub Ntawv Kev ruaj ntseg muaj nyob rau ntawm koj qhov kev thov.
Kev nyab xeeb:

Raws li GARS (Feem ntau Pom Zoo Raws Li Kev Nyab Xeeb) Daim Ntawv Ceeb Toom ntawm Teb Chaws Asmeskas, nws muaj kev nyab xeeb rau tib neeg noj.

9. Cov neeg siv lus pom

10. Peb Daim Ntawv Pov Thawj

11. Peb Cov Neeg Siv Khoom

12. Exhibition

Cim npe nrov: l-rhamnose monohydrate cas 6155-35-7, manufacturers, lwm tus neeg, Hoobkas, lag luam wholesale, yuav, nqe, zoo tshaj plaws, tej, kev muag khoom