Kono Chem Co., Ltd. Kev ua siab rau lub hauv paus ntsiab lus ntawm "los ntawm thiab kev mob siab rau". Kono tau nce siab nrog nws ua haujlwm rau cov neeg ua haujlwm ua haujlwm thiab kev nthuav dav thiab siv tau nws tus kheej hauv kev tsim cov tshuaj lom neeg ua ke nrog cov npoj yaig thiab txawv teb chaws thiab txawv teb chaws.
Vim li cas thiaj xaiv peb
Peb Lub Hoobkas
Tuam Tshoj Hoobkas hauv Hanzhong yog tsom rau cov neeg muaj cov tshuaj tua kab mob TCM, nws yog cov ntawv cog lus hauv nroog thiab sab qab teb Asia
Peb Cov Khoom
Tag nrho cheeb tsam ntawm lub Hoobkas yog 15 000 square metre, muaj ntau yam tshuaj ntsuab, ntau dua 3,000 cov tshuaj thiab cov khoom siv ntuj nti thiab tsim ib xyoos ib zaug.
Peb Daim Ntawv Pov Thawj
Peb yog Iso90001 lees paub thiab muaj ISO, FDA thiab lwm cov ntawv pov thawj los muab peb cov neeg siv khoom muaj cov khoom lag luam zoo, cov khoom lag luam siab. Nyob rau tib lub sijhawm, peb kuj txhawb nqa kev xeem ntawv thib peb-tog. Ib qho ntxiv, peb muaj cov cuab yeej siv siab thiab tuaj yeem lees txais cov neeg siv khoom 'OEM xaj lossis cov kev xav tau.
Kev ua lag luam tseem ceeb
Peb muaj cov qhua tuaj noj mov thoob plaws ntiaj teb hauv ntau yam kev lag luam. Tam sim no, ntau dua 80% ntawm peb cov khoom tau raug muag rau kaum ntawm cov teb chaws thiab cov cheeb tsam suav nrog Asmeskas Asmeskas, tshuaj pleev noj qab haus huv, tshuaj lom neeg, thiab ua liaj ua teb, thiab ua liaj ua teb.
Chlorogenic acid hmoov 327-97-9
Chlorogenic acid hmoov yog hom phenypropanoids pom hauv honeysuckle, eucommia thiab lwm yam nroj tsuag. Eucommia yog ib txwm suav tshuaj tshuaj noj thiab nws tau cog hauv Suav teb.
Alpha lipoic acid hmoov 99% 1077-28-7
Alpha Liphoic acid hmoov 99%, ua lub luag haujlwm ntawm lub luag haujlwm, uas yog ua rau muaj kev txiav txim siab, uas yog ua rau muaj cov pab pawg acyl.
Sialic acid hmoov tseem hu ua N-acetylneuraminic acid, thiab ua lub luag haujlwm tseem ceeb hauv kev kho mob ntawm tes thiab biochemical haujlwm ntawm tib neeg lub cev.
Nqaij nyuj daim siab hmoov, raws li cov zaub mov nplua nuj, muaj ntau yam haujlwm thiab cov txiaj ntsig. Nws tuaj yeem txhim kho kev tiv thaiv, txhawb kev loj hlob thiab kev txhim kho lub siab mob, tiv thaiv kev nkees, txhim kho lub cim xeeb, thiab lwm yam.
Balsam pear, txiv hmab txiv ntoo thiab zaub nrog cim cov tsos thiab qab zib thiab iab thiab iab saj, tau raug suav hais tias yog tej yam yees siv tshuaj ntsuab txij puag thaum ub.
Cochineal hmoov cas no 1343-78-8
Cochineal hmoov cas no 1343-78-8 yog ib qho ntuj anthraquinone xim uas txawv ntawm lwm cov khoom siv lub cev thiab tshuaj lom neeg ruaj khov. Nws yog ib qho zoo thiab compact hmoov nrog lub ci thiab khaub ncaws tsis sib xws.
Lub Bixin yog qhov ua tau lub ntuj xim xim tau muab rho tawm los ntawm cov noob aril ntawm bixaorellana, uas yog haiv neeg rau Central thiab South America. Nws yog mas tsim ntawm Bixin thiab Unbixin.
Superoxide dismutase Sod CAS 9054-89-1
SuperSebide dismutase, sau ntawv luv li sod, yog kev npaj tshiab enzyme. Nws yog dav faib nyob rau hauv lub ntiaj teb biological, yuav luag los ntawm cov tsiaj rau cov nroj tsuag, thiab txawm los ntawm tib neeg rau cov kab mob hauv ib leeg.
Bilirubin hmoov cas 635-65-4 yog cov saw zoo li tetrapyryrene compound thiab ib methylene choj, muaj plaub pyrrole rings.
Dab tsi yog sialic acid hmoov
Sialic acid yog ib pab pawg ntawm neuraminic acid pom nyob hauv cov tsiaj cov ntaub so ntswg thiab cov kua roj ua qhov chaw ntawm glycophcharides thiab Glycolipids thiab Glycolipids. Raws li lawv pom nyob rau hauv ntau dua ntau ntau hauv tib neeg ntau dua hauv cov mis nyuj bovine, nws yog ib qho tsim nyog los pab cov mis mos uas muaj lub zog no. Tib neeg cov kua mis yuav luag txhua yam muaj cov socic acid n-acetylneuraminic acid (neu5ac) tsuas yog khi dawb oligosaccharides.
Qhov Zoo Ntawm Sialic Acid Hmoov
Txhim kho kev txawj ntse thiab nco
Sialic acid yog ib qho tseem ceeb ntawm lub hlwb gangliosides. Kev Ntsiav tshuaj ntawm tes muaj 20 npaug dua li lwm cov hlwb. Txij li thaum kis tau lub hlwb cov ntaub ntawv thiab cov kev ua kom haum ntawm cov hlab ntshav yuav tsum tau los ntawm kev siv nyiaj txiag, sialic acid yog lub hlwb ntawm lub hlwb mis thiab synapses. Yog li ntawd, nws tuaj yeem txhawb txoj kev txhim kho ntawm lub cim xeeb thiab kev txawj ntse.
Anti-senile dementia
Nws yog qhov siab hauv tib neeg lub hlwb, uas yog ntsig txog kev loj hlob ntawm cov hlab hlwb. Cov neeg mob neurological kab mob xws li Alzheimer thiab tus mob schizophrenia tau txo qis ntawm sialic acid hauv lub hlwb lossis ntshav. Tom qab kev kho yeeb tshuaj, nws cov ntsiab lus rov qab los ua ib txwm muaj.
Txhim kho txoj hnyuv nqus ntawm cov vitamins thiab minerals
Nws tsis zoo them rau cov ntshav liab thiab lwm yam cells repel sib, zam kev sib cuam tshuam ntawm cov ntshav hauv qab. Raws li lub hauv paus ntsiab lus ntawm kev tawm tsam ntawm cov ntxhib, xws li ca 2 +
Cov tshuaj tua kab mob detoxification
Nws tuaj yeem tsim cov kab mob sib txuas nrog cov kab mob pathogenic, toxins, thiab cov kab mob nkag mus hauv cov hnyuv. Yog li tiv thaiv cov hnyuv rog, kab mob pathogenic, thiab tus kab mob parsles los ntawm kev sib txuas nrog cov hlab ntshav plab hnyuv.
Lub sialic acid tsev neeg suav nrog ntau lub derivatives ntawm cuaj-carbon qab zib neuraminic acid, tab sis cov acids no tsis tshua pom muaj qhov tseeb. Feem ntau lawv tuaj yeem pom raws li cov khoom siv ntawm oligosaccharide ntawm cov chaw carbohydrates ntawm cov chaw sab nraud thiab sab hauv uas lawv muaj peev xwm loj heev.
Kev suav ntawm cov pa roj carbon atoms pib ntawm lub carboxylate carbon thiab txuas ntxiv raws txoj saw hlau. Qhov kev teeb tsa uas muab lub carboxylate nyob rau hauv axial txoj hauj lwm yog alpha-anomer.
Alpha-Anomer yog daim foos uas pom tias thaum sialic acid yog khi rau glycans. Txawm li cas los xij, hauv kev daws, nws yog feem ntau yog (ntau dua 90%) nyob rau hauv cov beta-anomperic form. Cov kab mob enzyme nrog sialic acid mutilotase kev ua si ntawm sialic acid mus rau qhov sib npaug sib npaug ntawm 90% beta / 10% alpha tau nrhiav tau.
Nyob rau hauv sib piv rau lwm cov tsiaj, tib neeg yog tsis muaj peev xwm ua tau lub tshuab kua qaub sialic variant n-glycolylneurnuraminic acid (neu5gc). Me me ntawm neu5gC kuaj tau hauv tib neeg txawm li cas los xij yuav raug muab los ntawm exogenous (khoom noj khoom haus).
Lub davhlau ya nyob twg seid acid seem ntawm glycoconjugates pom cov khoom ua haujlwm tseem ceeb thiab kev sib txawv. Socic acid qib hauv ntshav thiab ncig xyuas glycopleins tau raug txhim kho los ntawm ntau lub neej muaj peev xwm ua rau muaj kev mob siab rau cov neeg hepatic asialogpicocoprotecople (asgpr).
Tsis tas li ntawd, FC sialylation tau tawm los ua lub tswvyim tseem ceeb rau kev ua kom muaj zog ntawm cov tshuaj tiv thaiv kab mob Txog cov kws kho mob thiab cov neeg mob, nws yog tus nqi zoo los txhim kho kev ua haujlwm ntawm lub Ivigical kev ua haujlwm ntawm Ivetent Ua Haujlwm nrog kev tsis yooj yim.
FC sialylation tej zaum yuav ua rau cov qauv teeb tsa thiab kev ua haujlwm hauv cov tshuaj tiv thaiv molecules. Feem ntau cov tshuaj tiv thaiv cov tshuaj tiv thaiv (cov kab mob muaj neeg) Yog li ntawd, nws yog ntshaw kom txhim kho cov kab ntawm tes uas tsim kom ua tau zoo siialylation ntawm IGG hauv FC.
Ntau cov kab lis kev cai tsis xws li cov qauv muaj txiaj ntsig zoo, Ph, cov pa dej thiab cov qib ammooylation thiab cov qib ammooylation thiab galactosylation theem feem ntau cuam tshuam. Muaj tswv yim biolab tau tsim muaj cov tshuaj tiv thaiv muaj zog glycoopitimize ntawm kev tsim kho cov tshuaj tiv thaiv cov tshuaj ntsuab, thiab lwm yam. Tsis tas li ntawd, hauv kev pom ntawm cov nyhuv sau cia ntawm FC sialylation hauv kev txo igg admec, peb tuaj yeem hloov kho cov tshuaj tua kab mob nrog cov tshuaj tiv thaiv kom tsawg. Cov hau kev uas peb thov tau muaj suav nrog tus tswv txawb ntawm glycoengineering.
Hloov chaw so kua qaub
Tom qab biosynthesis, neu5ac yuav tsum tau koom ua ke nrog nucleotide donor substrate rau kev hloov pauv mus rau ib qho kev hloov oligosaccharide. Qhov kev tsim qauv no yuav siv qhov chaw ntawm lub keeb ntawm eukaryotic hlwb. Neu5ac tau thauj mus rau lub nucleus; Qhov twg, nws yog txuas rau Cytidine 5'-triphosphate (CTP) los tsim cov nyiaj so los ntawm cryphodhaphat los ntawm catrothosphate hauv catalysis los ntawm enzyme cmp-neuac synecmas). CMP-neu5ac substrate yog ces thauj rov qab mus rau cytoplasm thiab tom qab ntawd rau golgi rau siv los ntawm siailylransferases.
Lub sialyltransferases (ST) Txuas Hmoob neu5ac seem rau oligosaccharides siv CMP-Neu5Ac ua cov suab thaj. Cov kev hloov pauv no tau tsim khoom tshwj xeeb glycosidic sib txuas rau cov sialic acid (2 → 3, 2 → 6, lossis 2 → 8) thiab muaj kev nyiam rau Monosaccharide Lees siv tau siv hauv txuas. Cov tshwj xeeb no tau qhia los ntawm enzyme nomrlature, piv txwv li, st6gal Kuv yog sialyltransferase uas ua rau galactose rau galactose.
Enzyme inhibitors feem ntau tau tsim raws cov qauv sib xws rau cov neeg muaj kev sib thooj los ntawm cov enzyme tsis tiav los ntawm enzyme thiab cov tshuaj tiv thaiv yuav tsum tsis txawv txav. Cov tswv yim no tau siv hauv kev sim uas siv Mansac analogs muaj cov txheej txheem tsis zoo li txoj kev los tiv thaiv sialic acid synthesis. Txawm li cas los xij, es tsis txhob cuam tshuam nrog sialic acid synthesis nrog lawv tsis muaj kev sib txuam nrog kev sib xyaw ua ke thiab tom qab ntawd ua ke ntawm oligosaccharides. Qhov no tsis muaj kev xaiv rau kev xaiv tsis zoo yuav tsis xav tsis thoob vim nws tau qhia cov soci acid acid hauv hluavtaws yog qhov tsim nyog rau vefrate Ciaj.
Kev tshem tawm UDP-GLCNAC {{{{}}}}} olimerase tau tso cai rau cov kws tshawb nrhiav glycan. Cov teeb tsa metabolic tau ua ke nrog cov tswv yim kev ua haujlwm, nyob rau hauv cov khoom siv acid Feem ntau ua tiav rau kev siv hauv Oligosaccharide engineering. Tsis pub siv cov analogs tau siv los tshawb xyuas cov kev tshwj xeeb Glycan tshwj xeeb ntawm cov kabmob qog nqaij hlav cancer uas qhia cov polysial acid.
Biosynthesis txoj kev ntawm sialylation
Sialic acid metabolism yog tswj hwm los ntawm sialyltransferases thiab sialidases. SialylTransferases, nyob ntawm hom II Membrane Protein ntawm Golgi Apparatus, catureSuring Rialic acid los ntawm Oligosaccharides thiab Glycoconjugates. SialylTransferases tau faib raws li txoj haujlwm ntawm sialic acid ntxiv (st3galtoside ({} { {{10 {}}, {{{}}} siagerthltransferases (ST8SIA). Sialidases, lossis neuraminidases (neu), kho kom haum rau cov txheej txheem desialation thiab tau cais ua plaub hom: neu1, neu3. Neu1, feem ntau lysosomal, yog koom nrog kev ua haujlwm, tsis muaj zog, phemocytosis, thiab elastic fiber sib dhos. Neu2, feem ntau pom nyob rau hauv Cytosol thiab ntshav membrane, koom nrog hauv MyLoblast thiab Neuronal sib txawv. Ob NEU3 thiab NEU4 yog cuam tshuam rau Neuronal sib txawv, thiab adhesion, nrog neu3 nyob hauv lub zos, mitochondria, thiab endoplasmic reticulum.
Lub sialylation-hloov kho cell cov qauv, lossis soolome, tau raug lees paub los ntawm ntau yam sialic acid-khi cov protein, pib ntau yam somic acid-nyob ntawm cov phiajcim. Sialylation kuj tseem muaj kev sib xyaw rau ntau lub zog kev ua haujlwm xws li cov protein ua haujlwm xws li cov protein conformation, tsiv teb tsaws, thiab kev nkag siab, thiab kev nkag siab.
Kev qhia tshwj xeeb ntawm sialic acid hmoov
Sialic acid hmoov tseem muaj lub npe hu ua n-acetylneuraminic kua qaub hmoov. Niaj hnub kev tshawb fawb txog kev kho mob niaj hnub tau pom tias sialic acid yog qhov tseem ceeb ntawm cov zaub mov zoo rau tib neeg lub cev. Qhov chaw seem no yog qhov tsis zoo them rau hauv physiological ntev thiab yog pom nyob rau hauv cov glyex glycans ntawm mucins thiab glycoproteins pom ntawm lub cell membrane.
|
Cov khoom |
Lub hom phiaj |
Fermentation |
|
Kev tshwm sim |
Cov hmoov dawb |
Ntawm kev pom |
|
Tus ntxhiab |
Qab zib thiab qaub saj |
Xwm txheej |
|
Lam xav |
Nlt98. 0% |
Kev Lag Luam Kev Lag Luam |
|
Yog li 42- (2% tshuaj) |
Nmt 0. 05% |
CP2015 |
|
pH |
1.8~2.3 |
CP2015 |
|
Poob rau ziab |
Nmt2. {0% |
CP2015 (105 OC, 3 H) |
|
Ignition residue |
Nmt2. {0% |
CP2015 (600 OC, 4 H) |
|
Pb |
Nmt 0. 8ppm |
CP2015 (AAS) |
|
Xws li |
Nmt 0. 4ppm |
CP2015 (AAS) |
|
Hg |
Nmt 0. 2ppm |
CP2015 (AAS) |
|
Tag Nrho Cov Phaj Suav |
Nmt1, 000 cfu / g |
CP2015 |
|
Poov xab / moulds |
Nmt100cfu / g |
CP2015 |
|
Tus encobacteriaceae |
Nmt60Mpn / 100g |
CP2015 |
|
Staphylococcus aureus |
Tsis pom |
CP2015 |
|
Tus ntses siav |
Tsis pom |
CP2015 |
Dab tsi cov zaub mov muaj cov kua qaub so acid
Sialic acid hmoov yog ib txwm muaj carbohydrate.it yog Ameslikas cais los ntawm cov mucin ntawm lub submandibular caj pas, li no lub npe.
N-acetylneuraminic acid yog ib lo lus tseem ceeb rau cov lus qhia txog cov txiv neej ntawm neuraminic acid, cuaj cov pa roj carbon monosaccharide. Nws tseem yog lub npe rau cov tswv cuab feem ntau ntawm pawg no, N-Acetylneuraminic acid (neu5ac lossis Nana) thiab qhov no yog lub npe siv los ntawm CIMA.
Nws yog feem ntau nyob rau hauv daim ntawv ntawm oligosaccharides, glycolipids lossis glycolipids lossis glycolipids lossis lub hlwb muaj 15 zaug ntawm lub siab, lub ntsws thiab lwm yam mob plab.
Lub ntsiab ntawm cov zaub mov tseem ceeb ntawm sialic acid hmoov yog cov mis nyuj, qe thiab cheese. le cov nqaij nyuj muaj xws li cov nqaij liab, thiab kom tsawg dua cov khoom noj.
Kev thov ntawm sialic acid hauv cov tshuaj pleev ib ce thiab chaw muag tshuaj
Cov kua qaub n-acetylneuraminic acid, kuj konwn raws li sialic icd, yog qhov tseem ceeb ntawm kev muaj suab thaj tseem ceeb uas haum ntawm kev sib txuas lus ntawm cellular. Sialic acid yog ib qho kev sib txuas ua ke foe xws li glycoproteins thiab gangliosides.
Hauv zaub mov thiab ntxiv
Sialic acid yog qhov tseem ceeb tshaj plaws nyob rau hauv lub hlwb, nws tau muaj pov thawj los ua cov khoom tseem ceeb hauv kev nco thiab kev kawm ua haujlwm.
Sialic acid yog ib qho ntawm cov khoom noj khoom haus uas tib neeg cov mis nyuj, nws txhim kho kev txhim kho hlwb ntawm cov menyuam mos.
Raws li ib qho ntawm yim qhov tseem ceeb glyconutrients rau humn lub cev, nws dav muaj nyob rau hauv lub cell membrane thiab neuron. Nws tuaj yeem txhim kho lub cev tiv thaiv kev tiv thaiv.
Hauv kom hniav zoo nkauj
Los tiv thaiv kev laus:Sialic acid yog ntuj mmp -1 inhibitor. Los ntawm kev txo qhov kev qhia ntawm mmp -1 thiab nws cov haujlwm. Sialic acid tuaj yeem ua rau cov kab mob hlwb rov qab mus rau cov xwm txheej zoo li qub, thiab tswj hwm lub cell stability, zoo heev txo cov ceev ntawm Cekk kev tawm suab. Thiab ncua sij hawm lifespan ntawm daim tawv nqaij yog li ti ua tiav cov txiaj ntsig ntawm kev laus. Yog li ntawd, kev siv ntev ntev siv cov khoom lag luam me me mos ntim tau muaj cov tawv nqaij acid tuaj yeem ncua kev laus tawv nqaij thiab txhawb nqa daim tawv nqaij ua kom tawv nqaij.
Whitening:Sialic acid tuaj yeem ua kom zoo tyrosine hydroxylase thiab DOPA HUDROXLASE kev ua si, tiv thaiv melanin cia li.
Sialic acid uas muaj glycoproteins (sialoglycophoutersins) khi xaiv hauv tib neeg thiab lwm yam muaj sia. Metastatic cancer cancer feem ntau qhia txog qhov siab tshaj ntawm cov kua qaub kua qaub npuas nplua nuj glycoproteins. Qhov no ovexervress ntawm sialic acid ntawm cov chaw muaj teeb meem tsis zoo them rau ntawm cov xovtooj ntawm tes. Qhov no tsim cov tshuaj rov qab ntawm cov hlwb (kev tawm tsam cell) thiab pab cov kab mob cancer theem no nkag mus rau cov ntshav dej. Cov kev sim tsis ntev los no tau pom muaj lub xub ntiag ntawm socic acid hauv cov qog nqaij hlav cancer.
Sialic acid-nplua nuj oligosaccharides ntawm glycoconjugates (glycolipids, glycolipids, glycolsins, muaj proteoglycans pab kom dej nyob rau saum npoo ntawm lub hau [citation xav tau]. Lub sialic acid-nplua nuj cheeb tsam muaj kev pab los tsim cov nqi tsis zoo ntawm lub hlwb 'chaw. Txij li thaum dej yog lub polar molecule nrog kev them nqi ib nrab ntawm ob qho tib si hydrogen atoms, nws yog nyiam rau ntawm thaj chaw ntawm tes thiab mis. Qhov no kuj ua rau muaj kev ua kom qhuav mis.
Sialic acid seem yog tam sim no nyob rau hauv mucin glycopleoteins ntawm mucus.
Sialic acid tuaj yeem "nkaum" mannose antigens ntawm cov npoo ntawm cov kab mob hlwb lossis kab mob los ntawm cov kab mob mannose.
Sialic acid nyob rau hauv daim ntawv ntawm polysialic acid yog qhov kev hloov pauv tshiab tshiab uas tshwm sim ntawm cov xov tooj ntawm tes tshiab (NCAMS). Nyob rau hauv lub synapse, tus muaj zog tsis zoo them ntawm polysialic acid tiv thaiv NCAM hla kev txuas ntawm cov hlwb.
Kev tswj hwm ntawm cov tshuaj estrogen rau cov nas uas muaj zog no ua rau muaj koob tshuaj-txo ntawm cov sialic acid cov ntsiab lus ntawm lub paum. Conversely, sialic acid cov ntsiab lus ntawm nas Vagina yog ib qho kev ntsuas ntawm lub potency ntawm cov tshuaj estrogen. Kev siv tshuaj yog estradiol rau cov ntawv thov subcutaneous thiab etinylestradiol rau kev tswj hwm qhov ncauj.
Kev thov ntawm sialic acids
Khoom Noj Khoom Haus
Qhov kev thov cuam tshuam ntawm cov kua qaub yog ntxiv rau nws rau cov mis mos mos mos ua rau txhawb nqa lub hlwb kev loj hlob. Ntxiv nws rau haus ua rau haus dej haus ua haujlwm. Kev haus dej haus ntev yuav tsis tsuas yog tiv thaiv khaub thuas tab sis kuj txhim kho lub peev xwm nqus tau ntawm cov vitamins thiab minerals.
Kws Tshuaj
Nws ua lub luag haujlwm tseem ceeb hauv cov kab mob khaub thuas, tshuaj tiv thaiv tus kab mob khaub thuas, tshuaj tiv thaiv kab mob, thiab tawm tsam kev ua pa tawm tsam. Ntawm tam sim no, tiv thaiv tus kab mob khaub thuas ua yeeb yam siv siv nws ua tus thawj coj ua ntej tau dhau los ua cov kev tshawb nrhiav hotspot.
Khoom Siv Kev Zoo Nkauj
Nws tuaj yeem siv los tsim cov khoom tu tawv nqaij rau kev txo cov tawv nqaij rau kev txo cov tawv nqaij, ntxuav hniav dawb, cov dej noo, noo noo.
Cov FAQ
Cim npe nrov: Sialic acid hmoov 131-48-6, Tuam Tshoj sialic acid hmoov {}} Cov chaw tsim khoom, cov chaw tsim khoom, Hoobkas
