Mecobalamin 13422-55-4

Kono Chem Co., Ltd. yog ib qho zoo tshaj plaws tuam ntxhab thiab cov muag khoom ntawm mecobalamin 13422-55-4 hauv Suav teb. Peb sov siab txais tos koj rau cov lag luam wholesale bulk mecobalamin 13422-55-4 muag ntawm no los ntawm peb lub hoobkas. Tag nrho cov khoom siv tshuaj muaj txiaj ntsig zoo thiab cov nqi sib tw.

1. Taw qhia

Mecobalamin yog cov tshuajactive coenzyme daim ntawvntawm vitamin B12, nrog cov tshuaj npe -(5,6-dimethylbenzimidazolyl)-Co-methylcobalamin. Nws yog tib hom vitamin B12 uas tuaj yeem ua rau lub cev muaj zog ncaj qha rau tib neeg lub cev yam tsis muaj daim siab metabolism.

Mecobalamin zoo li tsaus liab crystalline los yog crystalline hmoov, tsw thiab saj tsis qab. Nws yog me ntsis soluble hauv dej, yooj yim decomposable nyob rau hauv acidic los yog alkaline tej yam kev mob, thiab rhiab rau lub teeb thiab tshav kub- yog li yuav tsum tau kaw cia nyob rau hauv ib tug txias thiab tsaus qhov chaw.

2. Muaj nuj nqi

2.1.Puas koom hauv Nucleic Acid Synthesis thiab Cell Proliferation

Raws li ib tug coenzyme rau methionine synthase, mecobalamin txhawb lub methylation ntawm homocysteine ​​​​los tsim methionine, uas yog tus precursor rau synthesis ntawm S-adenosylmethionine (SAM). Raws li methyl pub dawb, SAM koom nrog hauv kev hloov pauv methylation ntawm DNA thiab RNA, ua lub luag haujlwm tseem ceeb hauv kev faib cell, kev loj hlob, thiab kev ruaj ntseg ntawm cov khoom siv caj dab-tshwj xeeb tshaj yog txhawb kev loj hlob ntawm cov pob txha pob txha hematopoietic qia hlwb thiab paj hlwb.

2.2. Tiv thaiv thiab txhim kho Megaloblastic Anemia

Deficiency ntawm mecobalamin impairs DNA synthesis, ua rau maturation mob ntawm cov pob txha pob txha hematopoietic hlwb thiab tom ntej megaloblastic anemia. Ntxiv nrog rau mecobalamin tuaj yeem kho qhov teeb meem no ncaj qha, txhawb erythropoiesis, thiab txo qis ntshav qab zib -cov tsos mob xws li kiv taub hau, qaug zog, thiab daj ntseg. Nws muaj txiaj ntsig zoo rau ntshav qab zib los ntawm folic acid deficiency lossis cais vitamin B12 tsis txaus.

3. Daim ntawv thov

3.1 Pharmaceutical Field

(1) Siv rau kev kho mob thiab tiv thaiv cov vitamin B12 tsis txaus, tshwj xeeb tshaj yog ua thawj - kab kev kho mob rau megaloblastic anemia.

(2) Kev kho mob dav siv raws li kev kho mob ntxiv rau peripheral neuropathies xws li mob ntshav qab zib peripheral neuropathy, postherpetic neuralgia, thiab cawv neuropathy, txo cov tsos mob cuam tshuam nrog cov hlab ntsha puas.

(3) tuaj yeem siv los txhim kho cov teeb meem neurological xws li kev paub tsis meej thiab kev nco tsis zoo los ntawm B12 tsis txaus.

3.2 Cov Khoom Muag Khoom Noj Kho Mob

(1) Raws li kev noj zaub mov ntxiv, nws tsim nyog rau cov neeg uas muaj kev pheej hmoo siab B12 tsis txaus, suav nrog cov neeg tsis noj nqaij, cov neeg laus, tom qab- cov neeg mob plab (nrog rau kev nqus tsis zoo), thiab ntev - cov neeg siv cawv, rau kev noj zaub mov noj txhua hnub.

(2) Lub hom phiaj cov tshuaj ntxiv (piv txwv li, "Mecobalamin + Folic Acid + Vitamin B6") muaj rau kev txo qis homocysteine, ua rau cov kev xav tau ntawm kev tswj cov hlab plawv.

4.Quality Standard

5.Txoj kev tsom xam

MOA muaj nyob rau thaum thov.

6. Kev ruaj ntseg thiab kev nyab xeeb

Compatibility nrog Common Excipients: Nws muaj kev sib raug zoo nrog qee cov tshuaj siv tshuaj xws li lactose, starch, thiab microcrystalline cellulose, tab sis nws yuav tsum tsis txhob muaj kev sib cuag nrog cov tshuaj txo qis, muaj zog oxidants, thiab hnyav hlau ions, uas yuav ua rau degradation.

Mob toxicity:Qhov mob toxicity ntawm mecobalamin tsawg heev. Hauv kev sim tsiaj, txawm tias nyob rau hauv cov koob tshuaj ntau heev, tsis muaj qhov pom tseeb tias mob toxic tshwm sim xws li tuag lossis mob hnyav.

Mob toxicity: Ntev- kev tswj hwm lub sij hawm nyob rau hauv cov tsiaj thiab tib neeg tsis tau pom tias ua rau muaj mob loj heev. Nws tsis ua kom pom tseeb kev puas tsuaj rau lub cev loj xws li lub siab, lub raum, thiab lub plawv.

7.Cov txheej txheem tsim khoom

7.1.Raw Material Synthesis/Preparation

Cyanocobalamin → Txo rau cobalamin (sodium borohydride) → Reacted nrog methylating tus neeg sawv cev (piv txwv li, methyl iodide) → crystallization → Pom → ziab → Crude mecobalamin

7.2.Raw Material Refining & Purification

Cov khoom Crude → Kem chromatography sib cais → HPLC purity xyuas → Recrystallization → Nqus kom qhuav (moisture Tsawg dua los yog sib npaug li 12.0%) → Cov khoom siv raw (purity ntau dua los yog sib npaug rau 98.0%)

8. Cov neeg siv lus pom

9.Peb Daim Ntawv Pov Thawj

10.Peb cov neeg muas zaub

11. Exhibitions

Cim npe nrov: Mecobalamin 13422-55-4, Tuam Tshoj mecobalamin 13422-55-4 manufacturers, lwm tus neeg, Hoobkas