CAS 81-25-4 Cholic Acid Hmoov

1. Taw qhia

Nws yog ib hom tshuaj organic uas nws cov mis molecular yog C24H40O5 thiab muaj nyob rau hauv cov kua tsib ntawm nyuj, yaj thiab npua. Nws yog xim dawb los yog dawb crystalline hmoov. Nws muaj ib tug iab saj thiab qab ntxiag saj tom qab saj nws. Lub melting point yog 198C thiab qhov tshwj xeeb curl (cysteine ​​0.6C, ethanol) yog ntxiv rau 37 degree .1g cholic acid yog soluble nyob rau hauv li 300ml ethanol los yog acetone, 7ml glacial acetic acid, thiab tsawg heev nyob rau hauv dej. Lub monohydrate yog dawb flake siv lead ua. Siv hauv kev tshawb fawb biochemical. Pharmaceutical intermediates. Cholic acid yog ib tug tswv tsev thiab microbiota-hais txog metabolite uas yog cov xim tsis muaj xim lossis dawb crystalline hmoov uas tswj hwm tus tswv tsev tiv thaiv kab mob thiab microbial virulence. Cholic acid yog tsim los ntawm lub siab thiab tawm mus rau hauv duodenum nrog cov kua tsib. Raws li ib feem ntawm cov kua txiv digestive, cholic acid tuaj yeem txhawb kev zom zaub mov thiab nqus cov lipids. Thaum pyloric tsis ua haujlwm, cholic acid yuav rov qab mus rau lub plab, ua ke nrog cov kua qaub ua rau lub plab zom mov, thiab ua rau mob plab thiab lwm yam tsis xis nyob, yog li ntawd, cholic acid yog ib qho ntawm cov tshuaj uas ua rau lub plab puas. Tam sim no, magnesium aluminium carbonate feem ntau siv hauv tsev kho mob tuaj yeem tsis tsuas yog neutralize gastric acid, tab sis kuj ua ke nrog cholic acid, yog li txo qhov kev puas tsuaj rau plab mucosa, uas yog qhov tsim nyog rau kev tshem tawm cov mob thiab kho cov kab mob. Tom qab siv tshuaj kho mob, cov tsos mob ntawm mob plab nyob rau hauv ntau cov neeg mob uas mob plab yuav zoo nyob rau hauv ib lub sij hawm luv luv, tab sis nws yuav siv sij hawm ib lub sij hawm rau cov mob mucosa yuav tsum tau kho tag nrho. Piv txwv li, feem ntau cov rwj yuav tsum tau 4 mus rau 6 lub lis piam ntawm kev kho mob tsis tu ncua, uas yog hais tias, tshem tawm cov tsos mob tsis tau txhais hais tias lub tsom xam tau txo, thiab nws yog tsim nyog los muab cov tshuaj tas mus li rau ib lub sij hawm. Nyob rau tib lub sijhawm, nws yog ib qho tsim nyog los kho qhov ua rau cov kua tsib reflux. Thaum kho, peb tseem yuav tsum tso tseg kev haus luam yeeb thiab cawv, tsis txhob haus cov khoom noj xws li kas fes thiab tshuaj yej muaj zog, thiab siv cov tshuaj uas ua rau lub plab zom mov, noj thiab ua neej nyob tsis tu ncua, thiab zam kev nruj thiab nkees. Rau qee tus neeg mob uas muaj kev ntxhov siab thiab kev nyuaj siab, nws raug nquahu kom muab cov tshuaj sib xws.

2. Muaj nuj nqi

2.1 Cholic acid tuaj yeem siv ua Emulsifier.
2.2 Siv hauv kev tshawb fawb biochemical, tshuaj intermediates. Sodium cholate yog cov tshuaj cholagogic rau kev kho mob cholecystitis, bile deficiency, plab hnyuv dyspepsia thiab lwm yam kab mob.
2.3 Cov organic acid nrog cov qauv steroid uas emulsifies rog thiab txhawb nws txoj hnyuv.

Kev zais ntawm cov kua tsib thiab lub luag haujlwm ntawm Cholic acid hauv kev zom zaub mov:

2.4 Non-denaturing ionic detergents rau extracting membrane proteins.
2.5 Qhov kev tsim kho muaj feem xyuam rau cov tshuaj ntxuav tes uas tsis yog-denaturing ion rau extracting membrane proteins.

3. Daim ntawv thov

Cholic acid yog siv rau kev kho mob.

4.Quality Standard

5.Txoj kev tsom xam

Kev txheeb xyuas

Noj cov khoom no 0.1mg, ntxiv 60 feem pua ​​glacial acetic acid tov 2ml. Ultrasonic kev kho mob rau 10 feeb kom yaj, lim, coj filtrate txog 1ml, muab tso rau hauv lub raj kuaj. Ntxiv cov tshuaj tshiab tshiab bran awakening kom nug (1: 100) 1ml thiab sulfuric acid tov (sulfuric acid 50ml tov nrog dej 65ml) 13ml, rhuab hauv dej da dej ntawm 70 degree, cov tshuaj yuav tsum yog xiav-ntsuab.
Cov cawv solubility ntawm cov khoom no yog 0.5g, ntxiv 50ml ntawm ethanol mus rau 60 degree thiab ultrasonic kho kom nws tag nrho yaj, sawv ntawm 20-25 degree rau 1 teev, cov tshuaj yuav tsum tau qhia meej thiab muaj. yuav tsum tsis muaj nag lossis daus.
Thaum cov khoom qhuav qhuav ntawm 105 degree rau 2 teev, qhov hnyav yuav tsum tsis pub tshaj 1.0 feem pua ​​(Tshooj IX g).
Cov hluav taws kub hnyiab yog 1.0g thiab tshuaj xyuas raws li txoj cai (Tshooj IX j). Cov seem seem yuav tsum tsis pub tshaj 0.3 feem pua ​​.
Kev npaj ntawm kev siv tshuaj yog muab los ntawm cholic acid siv tshuaj 12.5mg qhuav mus tas li qhov hnyav ntawm 105DEG C, hnyav hnyav, muab tso rau hauv 25ml ntsuas lub raj mis, yaj nrog 60 feem pua ​​​​glacial acetic acid tov, diluted rau nplai, shaken zoo, thiab tau (muaj cholic acid 0.5mg hauv txhua 1ml).
Rau kev npaj ntawm tus qauv nkhaus, qhov tseeb ntawm kev siv tshuaj {{0}}.2ml, 0.4ml, 0.6ml, {{10 }}.5ml thiab 1ml tau muab coj los tso rau hauv lub raj ntsaws. Txhua lub raj tau diluted rau hauv 1.0ml los ntawm kev ntxiv 60 feem pua ​​glacial acetic acid tov, ces cov tshiab npaj furfural tov (1-100) 1.0ml yog ntxiv, shaken zoo, thiab muab tso rau hauv ib da dej dej khov rau 5 feeb. Ntxiv sulfuric acid tov (50ml sulfate tov nrog dej 65ml) 13ml, sib tov zoo, thiab sov nws nyob rau hauv ib tug da dej ntawm 70 degree rau 10 feeb. Ceev nrooj txav mus rau hauv dej khov da dej thiab tawm hauv cov reagent coj mus ua ib qho khoob rau 2 feeb. Raws li UV-vis spectrophotometry (Appendix Ⅴ a), qhov absorbance tau txiav txim siab ntawm lub wavelength ntawm 605nm, thiab tus qauv nkhaus tau kos nrog absorbance li ordinate thiab concentration li Abscissa.
Txoj kev txiav txim siab yuav siv li ntawm 0.15g ntawm cov khoom no, qhov hnyav hnyav, muab tso rau hauv 50ml ntsuas lub raj mis, ntxiv 60 feem pua ​​glacial acetic acid tov uas tsim nyog, kev kho ultrasonic, tshem tawm, txias, ntxiv 60 feem pua ​​glacial acetic acid tov. diluted rau scale, co zoo, lim, pov tseg thawj zaug filtrate, precision coj filtrate 5ml, tso 50ml ntsuas lub raj mis, thiab dilute mus scale nrog 60 feem pua ​​glacial acetic acid tov, kom yog txhua txhua 1ml, qhov chaw nyob rau hauv ib tug thiab B xeem raj raws. Cov tshuaj furfural npaj tshiab 1ml tau ntxiv rau thawj lub raj thiab cov dej 1ml tau ntxiv rau lub raj thib ob raws li qhov khoob. Raws li cov txheej txheem nyob rau hauv kev npaj ntawm tus qauv nkhaus, qhov absorbance tau txiav txim siab raws li txoj cai los ntawm "tawm hauv dej khov rau 5 feeb". Qhov hnyav ntawm cholic acid nyob rau hauv cov tshuaj ntsuam xyuas yog nyeem tawm ntawm tus qauv nkhaus, xam thiab tau txais.
Cov khoom no muaj tsis pub tsawg dua 98.0 feem pua ​​cholic acid (c24hh40o5) raws li cov khoom qhuav.

6.HPLC
 

7. Kev ruaj ntseg thiab kev nyab xeeb
Kev ruaj ntseg:
Nyob ruaj khov nyob rau hauv cov xwm txheej zoo (chav kub). Cov Ntaub Ntawv Kev ruaj ntseg muaj nyob rau ntawm koj qhov kev thov.
Kev nyab xeeb:
Raws li kev tshawb fawb, nws muaj kev nyab xeeb rau tib neeg noj.

8. Flow Chart

9. Cov neeg siv lus pom
Peb muaj cov khw muag khoom ntawm Alibaba, Chemicalbook thiab LookChem, los ntawm cov khoom lag luam zoo thiab cov kev pabcuam tsis tau txais kev pabcuam, peb tau txais ntau cov lus pom zoo.
 

10.Peb Daim Ntawv Pov Thawj
Tau ntau xyoo, peb tau cog lus rau cov khoom tsim khoom optimization thiab kev tsim kom zoo. Peb tau teeb tsa qhov kev tswj hwm zoo thiab tau txais daim ntawv pov thawj ntawm nws.

11.Peb cov neeg muas zaub
Peb tau tsim kev lag luam kev sib raug zoo nrog Abbott, Unilever, Shiseido, KANS thiab SIMM, thiab lwm yam.

12. Exhibitions
Peb feem ntau tuaj koom kev nthuav qhia thoob ntiaj teb, suav nrog CPhI, FIC, API, Vitafoods, SupplesideWest.

Cim npe nrov: cas 81-25-4 cholic acid hmoov, manufacturers, lwm tus neeg, Hoobkas, lag luam wholesale, yuav, nqe, zoo tshaj plaws, tej, kev muag khoom