Lighocaine hmoov 137-58-6

1. Taw qhia

Lighocaine yog ib qho tshuaj loog hauv zos thiab tseem tuaj yeem siv rau kev kho mob xwm txheej ceev ntawm ventricular arrhythmia. Nrog tib neeg txoj kev tshawb fawb tob txog lidocaine, nws tau pom tias nws kuj qhia tau tias muaj txiaj ntsig zoo dua hauv kev kho mob lwm yam kab mob.

2. Muaj nuj nqi

1. Kev kho mob ntawm vestibular neuritis Lighocaine tuaj yeem thaiv qhov excitability ntawm cov hlab ntsha sympathetic ntawm cov hlab ntsha, txo nws cov contraction ntawm vascular du nqaij, thiab ua kom cov excitability ntawm parasympathetic qab haus huv los txhim kho cov ntshav microcirculation. Nws tuaj yeem txhim kho cov ntshav ntawm cov hlab ntsha nyob ib ncig ntawm cov hlab ntsha vestibular ntawm lub pob ntseg sab hauv thiab tshem tawm cov teeb meem ntawm endolymphatic reflux. Txoj kev: Lidocaine 50-100 mg intravenously, 200-400 mg nyob rau hauv mob hnyav ntxiv 5 feem pua ​​​​qabzib intravenously, ib hnub ib zaug, 3 hnub raws li kev kho mob.

2. Kev tiv thaiv kab mob plawv thaum lub sij hawm tracheal extubation. Endotracheal intubation ntawm cov tshuaj loog dav dav rau cov neeg mob yuav tsum tau muab tshem tawm thaum kawg ntawm kev ua haujlwm los ntawm kev txo cov tshuaj loog kom txog thaum lub laryngotracheal reflex rov qab los. Cov kab mob plawv zoo ib yam li cov intubation tuaj yeem tshwm sim thaum lub sijhawm extubation, thiab nws tuaj yeem ua rau hnoos, uas yog qhov tsis zoo rau cov neeg mob ntshav siab, kab mob plawv, thiab siab intracranial siab. Lidocaine tuaj yeem tiv thaiv cov tshuaj tiv thaiv no, kev siv yog lidocaine 1.5 mg / kg intravenously. Lub tshuab muaj feem xyuam nrog kev nyuaj siab hauv nruab nrab lossis kev nyuaj siab ntawm lub plawv.

3. Kev kho mob ntawm convulsions loj nyob rau hauv cov me nyuam mos Rau cov recurrent qaug dab peg, thawj load ntawm Lighocaine yog 2 mg/kg, ntxiv rau thawj zaug noj koob tshuaj ntawm 6 mg/kg intravenously ib teev, thiab cov tshuaj maj mam txo nyob rau hauv 3 hnub.

4. Rau kev tshuaj ntsuam xyuas gastroscopic intubation Muab 2 feem pua ​​​​Lighocaine rau hauv lub qhov ncauj, nqos maj mam rau 5 feeb, thiab ua qhov tshuaj xyuas intubation tom qab 10 feeb. Piv nrog rau 2 feem pua ​​​​tetracaine txau txoj kev, lidocaine muaj qhov zoo ntawm kev txuag lub sijhawm, yooj yim, thiab mob tsawg dua, thiab lidocaine muaj cov nyhuv sedative, uas tuaj yeem tshem tawm cov kev ntxhov siab ntawm tus neeg mob, txo cov plab hnyuv thiab lub plab zom mov.

5. Kev kho mob plab plab mob plab mob plab feem ntau tshwm sim los ntawm kev mob plab zom mov thiab nce gastric acid secretion, mucosal congestion, edema thiab txawm spasm. Qhov ncauj Lighocaine tuaj yeem txo qhov mob no, thiab kev siv yog 2 feem pua ​​​​Lighocaine 15 mg ntawm qhov ncauj.

6. Kev kho mob qaug dab peg Lighocaine tuaj yeem dhau los ntawm cov hlab ntsha-hlwb barrier, kev zoo siab thiab tom qab ntawd inhibit central neuron kev ua haujlwm, thiab tuaj yeem thaiv kev sib kis ntawm cov hlab ntsha thiab cov leeg nqaij. Nws muaj txiaj ntsig zoo rau cov xwm txheej epilepticus. Diluted nrog 0.1g lidocaine thiab txhaj tshuaj intravenously, qhov qaug dab peg yuav nres, thiab cov tshuaj tseem yuav siv tau yog tias qhov rov tshwm sim tshwm sim.

7. Kev kho mob hawb pob. Lighocaine yog ib qho muaj zog inhibitor ntawm kev hnoos hnoos thiab tuaj yeem ua rau mob hawb pob bronchial. Txoj kev: 5 ml (100 mg) ntawm lidocaine tau nqus los ntawm aerosol, ib hnub ib zaug, ua pa thiab lub plawv dhia rov qab mus rau qhov qub, hawb pob ploj, thiab lub sijhawm rov qab los ntawm cov roj ntsha hauv cov hlab ntshav tau luv dua li ntawm pawg tswj hwm.

8. Kev kho mob hiccups Cov txheej txheem ntawm Lighocaine hauv kev kho mob hiccups tuaj yeem cuam tshuam nrog nws qhov cuam tshuam rau kev cuam tshuam ntawm peripheral thiab hauv nruab nrab paj hlwb conduction. Kev Siv: Ntxiv 100 mg ntawm lidocaine rau Murphy's dropper, tom qab ntawd ntxiv 500 mg ntawm 10 feem pua ​​​​qabzib kom tswj tau cov tshuaj intravenously ntawm tus nqi ntawm 30-40 tee / min. Tom qab hiccups raug tswj, tswj nws li 1 mus rau 2 hnub.

9. Kho lub raum colic. Lighocaine muaj cov tshuaj antispasmodic, dilated ureter thiab me me analgesic teebmeem, uas yuav txo tau lub raum colic. Dilute nrog 100 mg ntawm Lighocaine thiab thawb nws intravenously, thiab ces muab ntxiv 200 mg rau infusion rau intravenous infusion.

10. Tsis-inhibited zais zis contraction tom qab kho. Lighocaine tuaj yeem nkag mus rau hauv mucosa los thaiv cov hlab ntsha peripheral, thiab ua rau hauv cov kua nplaum rau kev tswj hwm hauv qhov quav, uas tuaj yeem thaiv cov hlab ntsha ntawm cov leeg detrusor thiab inhibit qhov tsis muaj kev cuam tshuam ntawm cov leeg detrusor. Kev Siv: Kev tswj xyuas qhov quav nrog verapamil 40 mg, 5 feeb tom qab, thiab tom qab ntawd qhov quav tso quav ntawm 20 ml 2 feem pua ​​​​lidocaine, tus nqi zoo (71 feem pua) yog siab dua li ntawm pawg verapamil (38 feem pua).

4.Quality Standard

5. IHNMR

6.MOA

1. Cov tshuaj tiv thaiv nrog tooj liab sulfate kev tshuaj ntsuam xyuas: lidocaine hydrochloride muaj cov qauv amide uas muaj ntxhiab hauv nws cov molecule, uas tuaj yeem hnov ​​​​mob nrog tooj liab sulfate hauv sodium carbonate test tov los tsim xiav ntshav.

Xim complex; Nws hloov daj thaum yaj hauv trichloromethane.

2. Infrared spectroscopy: Suav Pharmacopoeia siv infrared spectroscopy los txheeb xyuas lidocaine hydrochloride. Nws tau teev tseg tias qhov infrared nqus spectrum ntawm cov khoom no yuav tsum yog tib yam li kev tswj hwm.

kev pom zoo.

3. Cov tshuaj chloride: lidocaine hydrochloride yog cov hydrochloride ntawm lidocaine, thiab muaj cov tshuaj chloride ion yuav tsum raug txheeb xyuas. Raws li daim ntawv txuas ntxiv ntawm Suav Pharmacopoeia "-

Cov txheej txheem raws li "chloride" hauv "kev ntsuas kev txheeb xyuas dav dav" yog tib yam li hauv qab kev txheeb xyuas ntawm procaine hydrochloride.

7.Flow chart

Nws yog tau los ntawm 2, 6-dimethylaniline los ntawm acylation thiab amination. 1. Acylation Dissolve 2,6-dimethylaniline hauv anhydrous benzene, txias kom qis dua 28 degree, ntxiv chloroacetyl chloride maj mam hauv qab nplawm, thiab tswj qhov kub hauv qab 30 degree. Do thiab hnov ​​​​mob rau 1h tom qab ntxiv, thiab tom qab ntawd kub thiab reflux rau 8h. Ua kom txias crystallization, lim thiab ziab kom tau 2, 6-dimethylchloroacetanilide. Cov txiaj ntsig yog 75 feem pua. 2. Amination Ntxiv cov saum toj no 2,6-dimethylchloroacetaniline rau hauv benzene nrog Chemicalbook, ntxiv diethylamine, do thiab kub rau refluxing rau 7h. Tom qab feem ntau ntawm cov benzene tau zoo lawm, nws yog txias thiab crystallized, lim thiab ntxuav nrog benzene. Muab cov tshuaj benzene, extract nrog 10 feem pua ​​hydrochloric acid, decolorize cov extraction tov nrog activated carbon, thiab lim. Kho cov pH ntawm cov filtrate rau 10 nrog 10 feem pua ​​​​sodium hydroxide tov, precipitate crystals, co thiab lim, ntxuav nws mus rau nruab nrab, thiab tau txais lidocaine. Lidocaine hydrochloride yog tsim los ntawm recrystallization thiab ntsev tsim nrog hydrochloric acid. Cov txiaj ntsig ntawm amination yog 76 feem pua.

8. Kev ruaj ntseg thiab kev nyab xeeb

Peb tau ua ntau yam kev ruaj ntseg thiab kev nyab xeeb kawm txog cov khoom no, raws li cov ntaub ntawv ceev ceev thiab kev ruaj ntseg mus sij hawm ntev, nws qhia cov yam ntxwv ruaj khov; raws li kev tshawb nrhiav tsiaj txhu, nws qhia tau tias muaj kev nyab xeeb.

9. Cov ntawv pov thawj

10.Main Clients

KONO CHEM CO.LTD tau dhau los ua tus tswv cuab tseem ceeb hauv kev muab cov hmoov elastin rau lub ntiaj teb nto moo zaub mov, tshuaj thiab tshuaj pleev ib ce tsim xws li, Johnson & Johnson, Hanhoo ...

11. Exhibitions

12.Cov neeg siv lus pom

Cim npe nrov: lighocaine hmoov 137-58-6, manufacturers, lwm tus neeg, Hoobkas, lag luam wholesale, yuav, nqe, zoo tshaj plaws, tej, kev muag khoom