Idebenone hmoovyog ib qho antioxidant uas tuaj yeem ua ntau yam teebmeem hauv lub cev. Nws tuaj yeem pab tshem tawm cov dawb radicals, txo cov oxidative kev nyuaj siab rau cov hlwb, thiab tiv thaiv cov hlwb los ntawm kev puas tsuaj oxidative. Tsis tas li ntawd, idebenone tuaj yeem txhawb nqa cell metabolism, txhim kho cell vitality thiab ua haujlwm. Nws tseem tuaj yeem txhim kho lub cev tiv thaiv kab mob, ntxiv dag zog rau kev tiv thaiv, thiab tiv thaiv qhov tshwm sim ntawm cov kab mob. Zuag qhia tag nrho, lub luag haujlwm tseem ceeb ntawm idebenone nyob rau hauv lub cev yog antioxidant, kev tiv thaiv kab mob, thiab txhawb kev loj hlob ntawm tes.
Idebenone hmoov yog daj crystalline lossis crystalline hmoov, tsw tsw. Tsis tshua muaj insoluble hauv dej, soluble hauv chloroform, methanol lossis anhydrous ethanol, soluble hauv ethyl acetate, thiab insoluble hauv n-hexane
Idebenone hmoov yog ib yam tshuaj rau kev txhim kho lub hlwb metabolism thiab cov tsos mob ntawm kev puas hlwb. Nws tuaj yeem ua rau mitochondrial ua pa ua pa, txhim kho lub hlwb lub zog metabolism, thiab txo cov tsos mob ntawm lub paj hlwb, kev puas siab puas ntsws, thiab kev tiv thaiv kev tsis sib haum xeeb hauv kev mob stroke thiab cov tsiaj sim ischemic. 1. Txhim kho cov nyhuv ntawm lub hlwb tsis ua haujlwm thaum lub hlwb ischemia:
① Cov khoom no muaj kev txhim kho cov nyhuv tom qab mob stroke, kev puas siab puas ntsws (txo cov kev txav ntawm lub cev, ua rau muaj kev cuam tshuam ntau ntxiv), ceg tawv nqaij tuag tes tuag taw, thiab lwm yam.
② Nws tuaj yeem txhim kho qhov kev tiv thaiv kev tiv thaiv tsis zoo hauv cov nas nrog kev sim cerebral infarction, kev sim hloov lub paj hlwb ischemia, thiab ob sab basal forebrain puas.
③ Cov khoom no tuaj yeem ncua lub sijhawm pib thiab tuag ntawm spasms hauv SHRSP nrog ob sab carotid artery ligation, thiab tseem ncua sijhawm tuag ntawm cov nas hypoxemic.
④ Nws muaj kev txhim kho cov ntsiab lus ntawm acetylcholine txo qis thiab 5-hydroxytryptamine metabolism hloov tshiab nyob rau hauv lub hlwb ntawm kev sim transient cerebral ischemia nas, thiab tuaj yeem nce monoamine metabolites hauv cov kua cerebrospinal ntawm cov neeg mob cerebrovascular.
2. Txhim kho cov txiaj ntsig ntawm lub hlwb lub zog metabolism hauv lub cev thaum lub paj hlwb ischemia:
① Nws muaj kev cuam tshuam rau kev txo qis ntawm ATP thiab nce lactate nyob rau hauv lub hlwb ntawm SHRSP nrog ob sab carotid artery ligation thiab kev sim hloov cov hlwb ischemia nas.
② Cov khoom no tuaj yeem rov qab siv cov piam thaj tsawg hauv lub hlwb ntawm cov nas nrog SHRSP mob stroke thiab kev puas tsuaj rau cov pob txha pob txha.
3. Ua kom muaj kev ua pa ntawm mitochondrial hauv lub hlwb:
① Succinic acid thiab NADH oxidase kev ua haujlwm (kev ua pa ua pa) tuaj yeem rov qab los hauv cov qauv mitochondrial ntawm cov neeg raug mob lub hlwb hauv vitro, uas tuaj yeem qhib lub tshuab hluav taws xob thauj khoom ua haujlwm ntawm nas hlwb mitochondria.
② Hauv vivo, nws tuaj yeem cuam tshuam kev tsim cov peroxidized lipids los ntawm nas thiab dev hlwb mitochondria, tiv thaiv cov kab mob mitochondrial membrane (o) cuam tshuam nrog peroxidized lipid ntau lawm, thiab tswj lawv txoj haujlwm.
Lub hlwb ua haujlwm txhim kho tuaj yeem txhim kho cov metabolism hauv lub hlwb lub zog, txhim kho lub hlwb ua haujlwm, thiab muaj cov nyhuv me me. Clinically siv rau cov neeg mob uas muaj lub hlwb tsis ua hauj lwm, tsis nco qab, tsis meej pem, tsis meej pem, hais lus tsis meej, dementia, thiab lwm yam tshwm sim los ntawm cerebral infarction, cerebral hemorrhage, thiab sequelae ntawm arteriosclerosis.
Yolanda
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