1. Taw qhia
Lumbrokinase (abbreviated li LK) yog ib pawg ntawm serine proteases nrog fibrinolysis thiab / los yog plasminogen ua kom. Lumbrokinase hmoov yog muab rho tawm los ntawm earthworms. Nws yog dav muaj nyob rau hauv ntau hom earthworms. Nws yog nplua nuj nyob rau hauv acidic amino acids, nrog ib tug hnyav molecular ntawm 20, 000 rau 40, 000 Daltons, nrog dual functions ntawm kinase thiab plasmin: Nws tsis tau tsuas yog ncaj qha degrade fibrin thiab fibrinogen zoo li plasmin.
2. Lub luag haujlwm tseem ceeb
2.1. Thrombolytic nyhuv
Raws li cov noob caj noob ces active enzyme khoom, nws feem ntau cov neeg sawv cev muaj nuj nqi yog cov tsis tshua muaj zog thrombolytic nyhuv. Nws cov txheej txheem ntawm kev ua yog: tom qab LK nkag mus rau hauv lub cev, nws sai sai ua ke nrog fibrin, lub ntsiab tivthaiv ntawm thromboembolism, thiab hydrolyzes nws mus cuag lub hom phiaj ntawm dissolving lub thrombus. Lumbrokinase hmoov tsis tsuas yog hydrolyzes plasminogen-nplua nuj fibrin, tab sis kuj hydrolyzes plasminogen-dawb fibrin hais. Yog li ntawd, nws kuj muaj ib tug haib nyhuv ntawm thrombolysis thiab tongmai rau tshiab thrombosis thiab qub thrombosis.
2.2. Anticoagulative nyhuv
Los ntawm kev soj ntsuam cov ntshav ntawm LK, nws tau pom tias LK tuaj yeem nqus cov coagulation yam tseem ceeb thiab hydrolyze lawv, thiab tib lub sijhawm inhibit qhov ntxiv adhesion ntawm platelets ntawm nws qhov chaw. Yog li ntawd, LK tswj cov thrombus uas twb muaj lawm thaum tiv thaiv qhov tshwm sim ntawm cov thrombus tshiab, uas daws cov teeb meem kho mob uas cov phab ntsa thrombus feem ntau ntog thiab tsim embolism nyob rau hauv lwm cov ntaub so ntswg thaum lub sij hawm txias ntawm thrombus, thiab txhim khu kev ruaj ntseg ntawm thrombolysis. . Nyob rau tib lub sijhawm, LK muaj lub hom phiaj muaj zog hauv cov txheej txheem ntawm thrombolysis thiab anticoagulation. Nws tsuas yog adsorbs thiab hydrolyzes coagulation yam tseem ceeb thiab platelets uas muaj ib tug nyiam coagulate, thiab tsis rhuav tshem cov ntshav coagulation mechanism, yog li thrombolysis thiab los ntshav yuav tsis tshwm sim.
2.3. Activating enzyme kev ua tau zoo
Kev soj ntsuam soj ntsuam pom: LK ua kom cov kab mob fibrinolytic hauv vivo. Nws tsim ib lub sij hawm ntev ruaj khov nyob rau hauv ib puag ncig uas tiv thaiv thrombosis hauv tib neeg lub cev, thiab muaj cov nyhuv antithrombotic ntev. Tsis tas li ntawd, lumbrokinase tuaj yeem ua rau lub sijhawm occlusion ntawm cov hlab ntsha, kom cov hlab ntsha tsis xav tau cov tshuaj sab nraud, tab sis txhim kho cov ntshav ntws los ntawm lawv tus kheej txoj cai elasticity, ua tiav cov ntaub so ntswg perfusion, thiab txhim kho cov ntaub so ntswg tseem ceeb.
2.4. Cov nyhuv ntawm activating hlwb
LK yog lub zog tshaj plaws proteolytic enzyme, uas tuaj yeem qhib ntau lub hlwb hauv tib neeg lub cev, tshwj xeeb tshaj yog rau cov hlwb hauv kev poob siab thiab ib nrab poob siab hauv cov ntaub so ntswg nrog cov ntshav tsis txaus, uas tuaj yeem rov qab ua haujlwm ntawm lub cev thiab kev ua haujlwm lom neeg sai sai. Yog li, LK muaj kev txhawb nqa zoo heev rau kev rov qab los ntawm cerebral thrombosis, sequelae ntawm cerebral infarction thiab myocardial infarction.
3. Cov ntawv thov
Lumbrokinases hmoov yog tsuas yog siv hauv cov tshuaj los kho cov kab mob ischemic cerebrovascular.
4. Flow Chart
Fresh earthworm ntxuav → sib tsoo → slagging → salting tawm → centrifugation → ultrafiltration → kem chromatography sib cais → ultrafiltration → pom → sterilization → ziab → lumbrokinase
5. Tus Qauv Zoo
Raws li Enterprise Standard
Cov khoom | Specifications | Cov txiaj ntsig |
Cim | Lub teeb daj hmoov, nrog hygroscopicity | Ua raws |
tsw | Yam ntxwv | Yam ntxwv |
Kev txheeb xyuas | ||
1 | Max nqus ntawm 278nm | Ua raws |
2 | Cov tshuaj tiv thaiv zoo | Cov tshuaj tiv thaiv zoo |
Cov hlau hnyav | ||
Pb | Tsawg dua lossis sib npaug li 1.5ppm | <> |
Raws li | Tsawg dua lossis sib npaug li 1ppm | <> |
Hg | Tsawg dua lossis sib npaug rau 0.1ppm | <> |
pH | 6.0-8.0 | 7.3 |
Poob rau ziab | Tsawg dua lossis sib npaug li 6.0 feem pua | 3.3 feem pua |
Muaj peev xwm | Lumbrokinase chav ua haujlwm / mg Ntau dua lossis sib npaug rau 16000 | 17716 |
Cov haujlwm tshwj xeeb | Ntau dua lossis sib npaug li 20000 | 27592 |
6. Txoj kev tsom xam
Raws li WS1-(X-052)-2001Z
7. Kev ua yeeb yam
8. Kev ruaj ntseg thiab kev nyab xeeb
Kev ruaj ntseg:
Nyob ruaj khov nyob rau hauv cov xwm txheej zoo (chav kub). Cov Ntaub Ntawv Kev ruaj ntseg muaj nyob rau ntawm koj qhov kev thov.
Kev nyab xeeb:
Raws li GARS (Feem ntau Pom Zoo Raws Li Kev Nyab Xeeb) Daim Ntawv Ceeb Toom ntawm Teb Chaws Asmeskas, nws muaj kev nyab xeeb rau tib neeg noj.
9. Cov neeg siv lus pom
10. Peb Daim Ntawv Pov Thawj
11.Peb cov neeg muas zaub
12. Exhibition
Cim npe nrov: Lumbrokinase hmoov, manufacturers, lwm tus neeg, Hoobkas, lag luam wholesale, yuav, nqe, zoo tshaj plaws, tej, kev muag khoom
