Azelaic Acid Powder CAS 123-99-9

1. Taw qhia

Azelaic acid hmoov yog cov organic compound nrog ntau yam kev siv. Ib yam li Fleming qhov kev tshawb pom tsis zoo ntawm penicillin, qhov kev tshawb pom ntawm azelaic acid kuj muaj ib zaj dab neeg, tab sis azelaic acid muaj hmoo ntau dua, tsawg kawg los ntawm kev tshawb pom mus rau lub tsev kho mob, nws dhau los ntawm ib tus neeg txhais tes nkaus xwb--Italian dermatologist Marcella Nazzaro Porro.

Nyob rau hauv txoj kev tshawb no, Dr. Marcella pom tias ntxiv cov fatty acids sib txawv (oleic acid, isooleic acid, parsillic acid) rau nruab nrab rau culturing Pityrosporum (tseem hu ua Malassezia tom qab) tuaj yeem tsim cov khoom sib txawv Dibasic acid. Thiab qee cov dibasic acids hauv nws tau pom muaj zog tyrosinase inhibitory kev ua haujlwm hauv kev sim hauv vitro. Cov khoom no dibasic acid yog azelaic acid.

2. Kev ua haujlwm

2.1. Whitening nyhuv

Raws li tau hais ua ntej, cov neeg nrhiav pom ntawm azelaic acid pib ua kom pom nws qhov kev ua haujlwm zoo tshaj tyrosinase inhibitory. Peb txhua tus paub tias tyrosinase yog lub luag haujlwm tseem ceeb rau kev sib txuas ntawm melanin hauv cov tsiaj thiab tib neeg. Nws tuaj yeem nkag siab yooj yim tias qhov siab dua qhov kev ua tyrosinase, ntau melanin tsim nyob rau hauv daim tawv nqaij. Yog li ntawd, azelaic acid muaj ib tug muaj zog whitening nyhuv.

Raws li tus qauv kub ntawm cov khoom xyaw ua kom dawb, hydroquinone ib txwm muab tawm rau PK nrog lwm cov khoom xyaw, thiab azelaic acid tsis tuaj yeem yog qhov zam. Yog li ntawd feem ntau ntawm cov kev tshawb fawb tom ntej ntawm kev siv azelaic acid ua kom dawb thiab tshem tawm freckle yog qhov pib los ntawm ob daim ntawv luam tawm 30 xyoo dhau los (1989 thiab 1991).

Cov kws tshawb fawb, uas tau kawm 241 tus neeg rau 6 lub hlis, pom tias 20 feem pua ​​​​ntawm azelaic acid muaj ze li ntawm cov nyhuv whitening li 4 feem pua ​​​​ntawm hydroquinone. Hais txog kev phiv tshuaj, azelaic acid tau coj kom zoo dua ntawm nws, thiab ob peb tus neeg qhia txog kev phiv.

Yog hais tias nws yog indistinguishable los ntawm 4 feem pua ​​hydroquinone, ces 20 feem pua ​​azelaic acid qhia nws tus kheej zoo piv rau 2 feem pua ​​hydroquinone. Tom qab tib 6 lub hlis, cov pab pawg azelaic acid tau txo qis dua hauv cheeb tsam ntawm hyperpigmentation.

Rau qee cov neeg uas muaj cov tawv nqaij hyperpigmented lossis melasma, ntau txoj kev ntxuav hniav dawb yuav muaj kev txwv, tab sis azelaic acid hmoov yuav yog ib qho kev xaiv, tsawg kawg yog ib qho ntxiv.

Cov neeg mob ntau tshaj plaws ntawm melasma tau pom nyob rau hauv ntau qhov chaw, randomized, ob leeg dig muag tswj kev sim ntawm 52 tus neeg tuaj yeem pab dawb nrog melasma thiab hyperpigmentation hnyav siv azelaic acid rau 6 lub hlis. Cov txiaj ntsig ntawm txoj kev tshawb fawb pom tias azelaic acid muaj qhov cuam tshuam rau melasma (qee qhov tshwm sim los ntawm cov tshuaj hormones) thiab hyperpigmentation.

(A. Ua ntej B. Tom qab 6 lub hlis)

2.2 Kho pob txuv

Leej twg yog thawj zaug pom tias azelaic acid tuaj yeem kho pob txuv? Yog lawm, nws kuj yog Marcella uas nrhiav tau azelaic acid.

Lub sijhawm ntawd, cov neeg kho mob uas tau koom nrog hauv kev kho mob melasma nrog azelaic acid tau hais rau nws tias lawv tau pom tsis pom tseeb tias lawv pob txuv kuj tau txhim kho zoo.

Raws li peb txhua tus paub, muaj peb yam tseem ceeb ntawm pob txuv: roj tso tawm los ntawm qib androgen siab, keratin txuam los ntawm keratinocytes txawv txav, thiab kab mob kab mob los ntawm ob qho laj thawj saum toj no. Kev sim tau pom tias azelaic acid tuaj yeem tswj cov khoom no zoo thiab muaj txiaj ntsig zoo rau pob txuv.

Hauv qhov loj, ntau qhov chaw, randomized, ib leeg-dig muag, tswj kev sim luam tawm xyoo 2016, cov kws tshawb fawb tau kho ntau dua 200 tus neeg mob uas muaj pob txuv me me mus rau nruab nrab nrog cov tshuaj sib txawv.

Ib pawg siv 3 feem pua ​​​​BPO ntxiv rau 1 feem pua ​​clindamycin CLN (qhov kev sib xyaw ua ke no kuj yog thawj kab tshuaj dermatological tam sim no rau kev kho pob txuv), thiab lwm pab pawg siv tsuas yog 20 feem pua ​​azelaic acid (AzA).

Tom qab 4 lub lis piam ntawm kev kho mob, cov kws tshawb fawb pom tias ob pawg tshuaj muaj txiaj ntsig zoo sib xws hauv kev kho pob txuv, tab sis azelaic acid tau zoo dua.

Raws li lwm cov tshuaj thawj zaug rau kev kho pob txuv thiab kaw lub qhov ncauj, adapalene kuj yog ib yam khoom pom zoo los ntawm kws kho mob dermatologist. Nws muaj qhov ua tau zoo thiab muaj qhov sib txawv me me piv rau lwm cov tswv cuab ntawm tsev neeg tretinoin vim nws cov kev xaiv tshwj xeeb ntawm receptors. Lwm qhov kev tshawb nrhiav ib leeg-dig muag tswj tau pom tias 15 feem pua ​​​​AzA piv rau 0.1 feem pua ​​​​adapalene.

Nyob rau tib lub sijhawm, kev ntsuas tshuaj tiv thaiv kuj tuaj yeem ua pov thawj tias cov nyhuv inhibitory ntawm azelaic acid ntawm cov staphylococcus cais tawm ntawm daim tawv nqaij kuj muaj zog heev, yog li nws muaj cov kab mob zoo.

Qhov tseem ceeb tshaj plaws yog qhov muaj peev xwm bacteriostatic zoo heev no yuav tsis ua rau cov tshuaj tua kab mob zoo li tiv thaiv vim siv mus ntev.

3. Cov ntawv thov

Azelaic acid hmoov yog siv rau hauv cov khoom siv tshuaj pleev ib ce. Nws kuj yog ib qho tseem ceeb organic synthesis nruab nrab. Nws kuj yog siv nyob rau hauv cov synthesis ntawm plasticizers nyob rau hauv plastics, roj hmab thiab lwm yam lag luam, nyob rau hauv lub synthesis ntawm low-temperature thiab high-speed lubricants nyob rau hauv aviation roj, thiab nyob rau hauv lub tsim ntawm electrolytic capacitors.

4. Flow Chart

Cottonseed roj → ntxiv oxidants ntawm cov khoom sib txawv (ozone, hydrogen peroxide thiab molecular oxygen, thiab lwm yam) → decomposing nws mus rau hauv cov khoom xws li azelaic acid thiab pelargonic acid → refining → azelaic acid

5. Tus Qauv Zoo

6. Txoj Kev Xeem

MOA muaj nyob rau thaum thov.

7. Spectrum

8. Kev ruaj ntseg thiab kev nyab xeeb

Kev ruaj ntseg:
Nyob ruaj khov nyob rau hauv cov xwm txheej zoo (chav kub). Cov Ntaub Ntawv Kev ruaj ntseg muaj nyob rau ntawm koj qhov kev thov.
Kev nyab xeeb:
Raws li GARS (Feem ntau Pom Zoo Raws Li Kev Nyab Xeeb) Daim Ntawv Ceeb Toom ntawm Teb Chaws Asmeskas, nws muaj kev nyab xeeb rau tib neeg siv.

9. Cov neeg siv lus pom

10.Peb Daim Ntawv Pov Thawj

11.Peb cov neeg muas zaub

12. Exhibitions

Cim npe nrov: azelaic acid hmoov cas 123-99-9, manufacturers, lwm tus neeg, Hoobkas, lag luam wholesale, yuav, nqe, zoo tshaj plaws, tej, kev muag khoom