Taw qhia
Paclitaxel Raw Hmoov 33069-62-4 tseem hu ua Taxol, taxol, purpurin, texel, yog qhov zoo tshaj plaws tshuaj anticancer uas tau pom muaj. Nws tau siv dav hauv kev kho mob qog noj ntshav mis, mob qog mis thiab qee qhov mob qog thiab caj dab thiab mob ntsws. Raws li diterpenoid alkaloid nrog kev ua haujlwm hauv anticancer, paclitaxel tau txais kev pom zoo zoo los ntawm botanists, chemists, pharmacologists thiab cov kws tsim tshuaj molecular vim nws cov ntawv tshiab thiab cov qauv hauv tshuaj lom neeg, kev ua haujlwm ntau thiab tseem ceeb, kev ua haujlwm tshiab thiab tshwj xeeb ntawm kev nqis tes ua thiab tsis tshua muaj cov khoom hauv lub ntiaj teb ib nrab ntawm lub xyoo pua, lub hnub qub los tiv thaiv mob qog noj ntshav thiab tshawb xyuas lub ntsej muag nyiam cov neeg nyiam thoob ntiaj teb.
Muaj nuj nqi
Xyoo 1979, Dr. Horwitz, kws tshuaj kws tshaj lij ntawm Einstein Medical College hauv Tebchaws Meskas, qhia meej txog qhov tshwj xeeb los tiv thaiv qog ntawm paclitaxel: Nws tuaj yeem ua rau tubulin thiab tubulin dimer poob sib npaug, tsim thiab txhawb tubulin polymerization, microtubule sib dhos thiab tiv thaiv. depolymerization, yog li ua kom lub zog microtubules, inhibit mitosis ntawm qog hlwb thiab ua rau cov cell apoptosis Nws tuaj yeem tiv thaiv kev loj hlob ntawm cov qog hlwb thiab ua lub luag haujlwm tiv thaiv mob qog nqaij hlav. Qhov tseeb, tubulin, uas cuam tshuam txog cell mitosis, muaj nyob rau yuav luag txhua lub hlwb eukaryotic. Lawv tuaj yeem ua polymerize reversibly mus rau microtubules, uas yog tsim nyog rau kev sib cais chromosome. Tom qab mitosis, cov microtubules no depolymerized rau hauv tubulin. Qee qhov tseem ceeb ntawm cov tshuaj anticancer, xws li colchicine, vinblastine thiab vincristine, ua lub luag haujlwm tiv thaiv qog los ntawm kev tiv thaiv microtubule protein polymerization. Hauv kev sib piv rau cov tshuaj tiv thaiv mitotic thiab tshuaj tiv thaiv qog, paclitaxel yog thawj cov tshuaj uas tuaj yeem cuam tshuam nrog tubulin polymer, uas yog, nws tuaj yeem tswj tau microtubules los ntawm kev khi nruj rau lawv. Tib lub sijhawm, nws pom tias paclitaxel muaj cov txiaj ntsig zoo ntawm ntau cov qog nqaij hlav tuaj. Qhov kev tshawb pom tshiab no tau ua rau ntau tus neeg xav paub txog biologist siv paclitaxel ua cov cuab yeej tshawb nrhiav kev tshawb fawb, tshawb txog thaj chaw tsis paub txog kev ua haujlwm ntawm tes thiab nrhiav tshuaj tshiab los tiv thaiv mob qog noj ntshav.
Thov
Paclitaxel Raw Hmoov 33069-62-4 yog ib qho ntuj me me ntawm qhov sib xyaw metabolite sib cais los ntawm cov tawv ntoo ntawm gymnosperm Taxus. Nws tau pom tias muaj txiaj ntsig zoo hauv kev kho mob tiv thaiv mob qog noj ntshav, tshwj xeeb tshaj yog mob kheesxaws ntawm zes qe menyuam, mob cancer ntawm lub tsev menyuam thiab mob qog mis uas muaj ntau yam mob cancer ntau. Paclitaxel yog cov tshuaj anticancer nrov tshaj plaws nyob rau hauv lub thoob ntiaj teb kev lag luam nyob rau xyoo tsis ntev los no, thiab tau pom tias yog ib qho kev tiv thaiv tshuaj zoo tshaj plaws hauv 20 xyoo tom ntej.
Specification
Kev Qhia Txog Tus Kheej | 1) Los ntawm IR Qauv thiab Standard IR spectra hauv cov roj ntxhia tawg 2) Los ntawm UV Lub teeb ntsuas kev nqus pom pom ntawm cov qauv daws teeb meem pom kev pom tseeb Max.282,275 thiab 230nm |
Ntsuas | 98.0% - 102.1% los ntawm HPLC (ntawm lub hauv paus tsis muaj zog) |
Chromatographic impurities A.Highestind ជន tsis muaj zog B.Unknownimpurity C.Total imputities | ≤ 0.5% ≤ 0.10% NMT1.0% |
Tsos | Kom dawb mus txog-dawb siv lead ua hmoov |
Solubility hauv Polysorbate-80 | 45.0mg / ml Min |
Tej Kev Hloov Kho Kom Zoo | -49.0º ∽-55.0º |
Cov kab mob endotoxins | 0.4EU / mg |
Hnyav hlau PPM | 20 PPM |
Noo noo | ≤3.0% |
Residue ntawm kev tiv thaiv | ≤0.2% |
Microbiology Tag Nrho Cov Phaj Suav Poov& Pwm E.Coli S. Aureus Salmonella | GG lt; 100cfu / g GG lt; 100cfu / g Cov kev xav tsis zoo Cov kev xav tsis zoo Cov kev xav tsis zoo |
FlowChart
Cim npe nrov: paclitaxel nyoos hmoov 33069-62-4, Suav teb, manufacturers, lwm tus neeg, Hoobkas, lag luam, lag luam, lag luam wholesale, yuav, nqi, tej, kev muag khoom
