Finasteride Raw Hmoov 98319-26-7

Taw qhia

Finasteride Raw Hmoov 98319-26-7, 4-azasteroid, yog ib qho tshwj xeeb ua kom tsis haum tshuaj intracellular enzyme hom II 5A reductase nyob rau hauv cov txheej txheem ntawm testosterone metabolism ua kom muaj zog dihydrotestosterone. Benign prostatic hyperplasia, lossis prostatic hypertrophy, nyob ntawm qhov hloov pauv ntawm testosterone rau dihydrotestosterone hauv prostate. Cov tshuaj no tuaj yeem txo qis dihydrotestosterone hauv cov ntshav thiab prostate. Finasteride tsis muaj qhov sib txuam rau androgen receptors. Finasteride yog 5 α - reductase inhibitor. Nws tuaj yeem inhibit qhov hloov pauv ntawm testosterone rau dihydrotestosterone (DHT), txo cov qog prostate, txhim kho cov tsos mob, nce tso zis txaus, thiab tiv thaiv kev nce qib ntawm benign prostatic hyperplasia (BPH).

Muaj nuj nqi

Finasteride, 4-azasteroid, yog qhov tshwj xeeb inhibitor ntawm intracellular enzyme hom II 5A reductase hauv cov txheej txheem ntawm cov metabolism metabolism hauv ua kom muaj zog dihydrotestosterone. Benign prostatic hyperplasia, lossis prostatic hypertrophy, nyob ntawm qhov hloov pauv ntawm testosterone rau dihydrotestosterone hauv prostate. Cov tshuaj no tuaj yeem txo qis dihydrotestosterone hauv cov ntshav thiab prostate. Finasteride tsis muaj qhov sib txuam rau androgen receptors.

Hauv kev ua kom tau ntev thiab kev nyab xeeb txog kev siv tshuaj * (PLESS), 3016 cov neeg mob uas muaj qhov nruab nrab mus rau ntau qhov tsos mob BPH uas tau txais 4 xyoo ntawm kev noj tshuaj tau raug soj ntsuam rau kev cuam tshuam urologic (kev phais mob), xws li transurethral rov qab ntawm prostate thiab lwm yam prostatectomy lossis tso zis ceev kom tau tso ntshav tawm ntawm cov leeg. Hauv no ob-dig muag, randomized, placebo-multicenter txoj kev tshawb no, kev kho mob nrog cov tshuaj no ua rau 51% txo qhov kev pheej hmoo ntawm kev tso zis tawm tag nrho, nrog los ntawm qhov tseem ceeb thiab txhawb kev txo qis hauv prostate ntim, qhov nce siab nyob rau hauv cov zis ntau tshaj plaws tus nqi ntws thiab cov tsos mob txhim kho.

Daim ntaub plaub hau poob:

Finasteride Raw Hmoov 98319-26-7 yog ib qho hluavtaws steroid, uas yog ib qho tshwj xeeb inhibitor ntawm intracellular enzyme hom II 5 α reductase hauv cov txheej txheem ntawm androgen testosterone metabolism rau hauv dihydrotestosterone. Finasteride tsis muaj qhov sib thooj rau androgen receptor, thiab nws tsis muaj androgen li, antiandrogen zoo li, estrogen zoo li, anti estrogen zoo li lossis cev xeeb tub los txhawb cov teebmeem. Qhov inhibition ntawm lub enzyme tuaj yeem thaiv qhov piv ntawm testosterone rau androgen nyob rau hauv cov ntaub so ntswg peripheral, thiab nce qib ntawm testosterone nyob rau hauv cov ntshav ncig los ntawm kwv yees li 10-15%, tab sis nws tseem nyob hauv lub zog ntau. Finasteride tuaj yeem txo qis qhov kev ua haujlwm ntawm dihydrotestosterone hauv cov ntshav dej, uas yog txo qis hauv 24 teev tom qab kev coj noj coj ua.

Cov hauv paus plaub hau muaj hom II 5 α - reductase. Hauv cov txiv neej mob neeg mob alopecia, tsawg dua cov hauv paus plaub hau thiab muaj cov dihydrotestosterone ntau. Finasteride tuaj yeem txo qis ntawm dihydrotestosterone hauv tawv taub hau thiab ntshav dej ntawm cov neeg mob no. Tus txiv neej nrog mob qog mis ntawm hom II 5 α - reductase tsis tsim txiv neej do hau. Cov ntaub ntawv no thiab cov txiaj ntsig ntawm kev tshawb fawb tshawb pom tseeb tias finasteride tuaj yeem cuam tshuam kev txo qis ntawm cov plaub hau plaub hau thiab rov qab cov plaub hau ua tiav.

[Tus txiv neej kev tshawb fawb]

Peb qhov kev tshawb fawb soj ntsuam koom nrog 1879 tus txiv neej hnub nyoog 18 txog 41 tau pom qhov ua tau zoo ntawm cov khoom. Tus txiv neej raug kev txom nyem los ntawm plaub hau me me mus rau plaub hau hle. Hauv cov kev tshawb fawb no, plaub qhov ntsuas tau siv los ntsuas kev loj hlob cov plaub hau: suav cov plaub hau, muab qhab nia los ntawm cov kws kho dermatologist raws li cov duab, tshawb' s kev ntsuas, thiab kev ntsuas tus kheej'

Ob txoj kev tshawb fawb soj ntsuam nrog cov txiv neej uas tau kho nrog cov khoom no rau 5 xyoo thiab cov uas tau poob lawv cov plaub hau ntawm lawv lub taub hau pom tias lawv tus mob tau zoo dua nyob rau thawj peb lub hlis ntawm kev kho mob, piv nrog rau cov ua ntej kho thiab hauv cov pab pawg. Cov txiaj ntsig ntawm kev kho mob 5-xyoo pom tau tias 90% ntawm cov neeg mob tau txiav plaub hau raws li kev soj ntsuam kev yees duab; 93% ntawm cov neeg mob tso tseg cov plaub hau raws li kev ntsuam xyuas ntawm cov kws tshawb nrhiav. Tsis tas li ntawd, raws li cov plaub hau suav, 65% ntawm cov neeg mob kho nrog baofaliz tau nce cov plaub hau kev loj hlob, piv nrog 0% hauv cov pawg placebo; raws li kev ntsuam xyuas daim duab, 48% ntawm cov neeg mob kho nrog cov khoom lag luam tau nce cov plaub hau kev loj hlob, piv nrog 6% hauv cov pawg placebo; raws li kev soj ntsuam' s kev soj ntsuam, 77% ntawm cov neeg mob kho nrog cov khoom lag luam tau nce cov plaub hau kev loj hlob, piv nrog 15% hauv cov pawg placebo.

Kev tshawb pom 12 lub hlis ntawm cov txiv neej nrog anterior parietal plaub hau ploj tau raug soj ntsuam uas siv tib txoj kev piav qhia saum toj no, thiab cov txiaj ntsig tseem tau lees tias kev txhim kho tseem ceeb hauv cov plaub hau plaub hau kev loj hlob thiab cov tsos mob hauv cov neeg mob kho nrog cov khoom no.

Hauv cov ntsiab lus, cov kev tshawb fawb no qhia tau hais tias kev kho nrog cov khoom no tuaj yeem ua rau cov plaub hau kev loj hlob thiab tiv thaiv cov txiv neej txiv neej nrog androgen alopecia txuas ntxiv poob lawv cov plaub hau.

[Qhov kev tshawb fawb poj niam]

12-lub hlis, cov tshuaj placebo-soj ntsuam kev tshawb (n=137) paub tseeb tias kev kho mob nrog cov khoom no tsis muaj txiaj ntsig hauv cov poj niam tom qab muaj tus androgen alopecia, thiab tias nws tau txhim kho zoo ntawm cov plaub hau suav, kev ntsuas tus kheej ntawm tus neeg mob, kev tshuaj ntsuam xyuas, thiab kev muab qhab nia raws li cov duab txheem, piv nrog pab pawg placebo.

Spkev nyob nyab xeeb

NtwsDaim duab

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