Khoom siv Ketoconazole Hmoov 65277-42-1

1. Taw qhia

Khoom siv Ketoconazole Powder 65277-42-1 yog ib tug dav-spectrum antifungal tshuaj ntawm imidazoles, uas inhibits lub biosynthesis ntawm ergosterol nyob rau hauv lub cell daim nyias nyias ntawm fungi los ntawm heev xaiv cuam tshuam nrog cov kev ua ntawm cytochrome Pmur450. Nws muaj txiaj ntsig zoo rau ob qho tib si sab saum toj thiab sib sib zog nqus fungal kab mob, uas tuaj yeem tsis tsuas yog inhibit qhov kev loj hlob ntawm fungi, tab sis kuj inhibit qhov kev hloov ntawm spores rau hauv mycelium thiab tiv thaiv kev kis kab mob ntxiv. Tsawg concentration bacteriostasis, siab concentration sterilization. Nws muaj cov nyhuv antibacterial ntawm Candida, Coloured fungi, coccidiomycetes, histoplasmosis, sporomycetes thiab Trichophyton trichophyton.

2. Muaj nuj nqi

2.1 Ketoconazole hmoov yog ib qho tshuaj imidazole antifungal, thiab nws cov txheej txheem yog inhibit biosynthesis ntawm ergosterol hauv fungal cell membrane, cuam tshuam rau permeability ntawm cell membrane thiab inhibit nws txoj kev loj hlob.

2.2 Nws tuaj yeem siv los kho mycosis superficial thiab tob, xws li daim tawv nqaij thiab cov ntiv tes tinea, qhov chaw mos Candida albicans, kab mob plab hnyuv, nrog rau cov kab mob uas tshwm sim los ntawm Candida albicans, coccidioidosis, histoplasmosis, thiab lwm yam.

3. Daim ntawv thov

Khoom siv Ketoconazole Powder 65277-42-1 yog siv hauv kev lag luam kws tshuaj.

4.Quality Standard

5.Txoj kev tsom xam

DEFINITION Ketoconazole muaj NLT 98. IDENTIFICATION Hloov los nyeem: • A. ▲SPECTROSCOPIC IDENTIFICATION TESTS á197ñ, Infrared Spectroscopy: 197K▲ (CN 1-Tsib Hlis-2020) • B. Lub sijhawm khaws cia ntawm qhov siab tshaj plaws ntawm cov qauv kev daws teeb meem sib raug rau qhov ntawd ntawm qhov kev daws teeb meem, raws li tau txais hauv Assay. ASSAY • PROCEDURE Buffer: 3.4 mg/mL ntawm tetrabutyl ammonium hydrogen sulfate hauv dej Solution A: Acetonitrile thiab Buffer (5:95) Solution B: Acetonitrile thiab Buffer (50:50) Txawb theem: Saib Table 1.

Table 1

Diluent: Methanol Standard tov: {{0}}.1 mg/mL ntawm USP Ketoconazole RS hauv DiluentSample kua: 0.1 mg/mL ntawm Ketoconazole hauv Diluent Chromatographic system (Saib Chromatography á621ñ, System Suitability.) Hom: LC Detector: UV 225 nm Kab: 4.6-mm × 10-cm; 3-µm packing L1 Flow rate: 2. feem pua.

Kev Ntsuas Cov Qauv: Cov qauv kev daws teeb meem thiab cov qauv kev daws teeb meem suav cov feem pua ​​​​ntawm ketoconazole (C26H28Cl2N4O4) hauv ib feem ntawm Ketoconazole noj:

Cov txiaj ntsig=(r U/r S ) × (CS / CU) × 100

r U=cov lus teb siab kawg los ntawm cov qauv kev daws teeb meem

r S=ncov teb los ntawm Standard tov

CS=concentration ntawm USP Ketoconazole RS nyob rau hauv Standard tov (mg/mL)

CU=concentration ntawm Ketoconazole hauv cov kua tshuaj (mg/mL)

Cov qauv lees txais: 98.0 feem pua ​​-102.0 feem pua ​​​​ntawm lub hauv paus qhuav

IMPURITIES • RESIDUE ON IGNITION á281ñ Sample: 2 g Cov qauv lees txais: NMT 0.1 feem pua ​​• ORGANIC IMPURITIES Buffer, Solution A, Solution B, Mobile theem, Diluent, thiab Chromatographic system: Ua raws li qhia hauv Assay. Standard tov: 0.01 mg/mL txhua ntawm USP Ketoconazole RS thiab USP Terconazole RS hauv Diluent Sample kua 10.0 mg/mL ntawm Ketoconazole hauv Diluent Cov qauv tsim nyog: Cov qauv kev daws teeb meem Kev xav tau Kev daws teeb meem: NLT 2.0 nruab nrab ntawm ketoconazole thiab terconazole peaks Tus txheeb ze tus qauv sib txawv: NMT 5.0 feem pua ​​​​rau ketoconazole ncov Kev Ntsuam Xyuas Cov Qauv: Cov qauv kev daws teeb meem thiab cov qauv ntsuas suav feem pua ​​​​ntawm cov impurities hauv feem ntawm Ketoconazole noj:

Cov txiaj ntsig=(r U/r S ) × (CS / CU) × 100

r U=ncov teb ntawm tej impurities los ntawm cov qauv tov

r S=ncov teb ntawm Ketoconazole los ntawm Standard tov

CS=concentration ntawm USP Ketoconazole RS nyob rau hauv Standard tov (mg/mL)

CU=concentration ntawm Ketoconazole hauv cov kua tshuaj (mg/mL)

Kev lees txais cov qauv: Tsis lees paub qhov siab tshaj qhov tsawg dua {{0}}.05 feem pua ​​. Txhua tus neeg tsis paub meej impurity: NMT 0.10 feem pua ​​​​Tag nrho impurities: NMT 2.0 feem pua

6.HPLC

7. Kev ruaj ntseg thiab kev nyab xeeb

Kev ruaj ntseg:

Nyob ruaj khov nyob rau hauv cov xwm txheej zoo (chav kub). Cov Ntaub Ntawv Kev ruaj ntseg muaj nyob rau ntawm koj qhov kev thov.
Kev nyab xeeb:
Raws li kev tshawb fawb, nws muaj kev nyab xeeb rau tib neeg noj.

8.Flow chart

9. Cov neeg siv lus pom

Peb muaj cov khw muag khoom ntawm Alibaba, Chemicalbook thiab LookChem, los ntawm cov khoom lag luam zoo thiab cov kev pabcuam tsis tau txais kev pabcuam, peb tau txais ntau cov lus pom zoo

10.Peb Daim Ntawv Pov Thawj

Tau ntau xyoo, peb tau cog lus rau cov khoom tsim khoom optimization thiab kev tsim kom zoo. Peb tau teeb tsa qhov kev tswj hwm zoo thiab tau txais daim ntawv pov thawj ntawm nws.

11.Peb cov neeg muas zaub

Peb tau tsim kev lag luam kev sib raug zoo nrog Abbott, Unilever, Shiseido, KANS thiab SIMM, thiab lwm yam.

12. Exhibition

Peb feem ntau tuaj koom kev nthuav qhia thoob ntiaj teb, suav nrog CPhI, FIC, API, Vitafoods, SupplesideWest.

Cim npe nrov: ketoconazole hmoov 65277-42-1, manufacturers, lwm tus neeg, Hoobkas, lag luam wholesale, yuav, nqe, zoo tshaj plaws, tej, kev muag khoom