Betulinic Acid Hmoov 472-15-1

1. Taw qhia

Betulinic acid yog ib tug tsib-ntiv nplhaib triterpenoid compound, uas yog dav nyob rau hauv cov xwm thiab yog thawj zaug cais los ntawm cov tawv ntoo ntawm evergreen nroj tsuag ntawm Rhamnaceae tsev neeg uas loj hlob nyob rau hauv sab hnub tuaj Africa.Lub birch triterpenoids feem ntau muaj xws li betulin thiab betulinic acid, uas yog lupane- hom triterpenoids muab tau los ntawm cov tawv ntoo ntawm tsob ntoo birch. Betila triterpenes muaj ntau yam kev ua ub no thiab tuaj yeem siv rau hauv tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tiv thaiv lipid, cholestatic thiab hepatoprotective daim ntaub ntawv.

2. Lub luag haujlwm tseem ceeb

2. Lub luag haujlwm tseem ceeb

Raws li cov qog nqaij hlav malignant, ib qho ntawm tsib kab mob tuag taus ntawm tib neeg, yog ib qho kev hem thawj loj rau tib neeg lub neej thiab kev noj qab haus huv, kev loj hlob ntawm cov tshuaj tiv thaiv qog tau dhau los ua ib qho kev qhia nrov rau kev tsim tshuaj. Cov kev tshawb fawb tau pom tias betulinic acid muaj qhov cuam tshuam loj rau kev loj hlob ntawm tib neeg mob qog noj ntshav HeLa hlwb, tib neeg lub siab mob cancer SMMC-7721 hlwb thiab tib neeg mob plab hnyuv SGC-7901 hlwb hauv vitro. Nyob rau hauv sib piv, cov tshuaj tiv thaiv qog nqaij hlav ntawm betulinic acid yog muaj zog tshaj li ntawm betulinic cawv. Betulinic acid muaj kev tiv thaiv kev loj hlob ntawm ntau cov qog hlwb xws li melanoma, mob qog noj ntshav, mob qog noj ntshav, mob qog noj ntshav, mob qog nqaij hlav, lub taub hau thiab caj dab, leukemia, qog nqaij hlav hauv tib neeg lub ncauj tsev menyuam, qog nqaij hlav me me hauv lub ntsws, mob qog noj ntshav ntawm lub mis, nasopharyngeal carcinoma, lymphoma thiab mob qog nqaij hlav hauv plab, thaum tsis muaj kev cuam tshuam rau cov hlwb ib txwm muaj. Betulinic acid derivatives kuj muaj cov khoom tiv thaiv qog.

2.1 Lub ntsiab antitumour teebmeem ntawm betulinic acid thiab nws cov derivatives muaj xws li hauv qab no.

2.1.1. Cytotoxic cuam tshuam rau cov qog hlwb

2.1.2. Thaiv lub voj voog ntawm cov qog hlwb

2.1.3. Targeted induction ntawm apoptosis thiab autophagy hauv cov qog hlwb

2.1.4. Inducing qog cell txawv

2.1.5. Thaiv qog cell migration, ntxeem tau thiab lwm yam teebmeem

2.1.6. Txhim kho kev tiv thaiv kab mob ntawm lub cev

2.2 Antiviral teebmeem ntawm betulinic acid thiab nws cov derivatives

Cov kab mob yog ib pawg ntawm cov tseem ceeb, nyob, cov kab mob uas tsis yog cellular muaj peev xwm ntawm tus kheej-replication thiab nruj intracellular parasitism. 70 feem pua ​​​​rau 80 feem pua ​​​​ntawm tib neeg cov kab mob kis tau los ntawm cov kab mob, xws li kis kab mob tiv thaiv kab mob (AIDS), mob npaws, kab mob siab B thiab C, herpes zoster, thiab lwm yam. Cov kab mob tuaj yeem ua rau cov qog nqaij hlav, thiab cov kab mob no hu ua RNA qog viruses. Cov birch triterpenoids muaj cov tshuaj pharmacological los tiv thaiv ntau tus kab mob thiab txo cov tsos mob ntawm cov kab mob los ntawm ntau tus kab mob.

Cov txheej txheem ntawm kev ua ntawm cov tshuaj tam sim no tawm tsam cov kab mob feem ntau yog nyob ntawm ntau theem ntawm tus kab mob rov ua dua tshiab raws li lub hom phiaj ntawm kev ua. Vim muaj qhov sib txawv ntawm cov tshuaj nucleic acid, cov kab mob tuaj yeem muab faib ua cov kab mob RNA (ib zaug-los yog ob-kab) thiab DNA viruses (ib zaug-los yog ob-stranded), thiab cov hom phiaj ntawm cov tshuaj inhibition sib txawv rau cov kab mob nrog cov khoom siv sib txawv. Rau cov kab mob nrog DNA ua cov khoom siv caj ces, lub hom phiaj tshwj xeeb ntawm kev ua yog DNA polymutase, xws li inhibition of herpes zoster virus, human herpes virus, type I thiab II herpes simplex viruses by acyclovir thiab ganciclovir; rau retroviruses nrog RNA raws li cov khoom siv caj ces, lub hom phiaj tshwj xeeb ntawm kev ua yog qhov rov qab transcriptase, feem ntau pom nyob rau hauv inhibition ntawm HIV los ntawm zidovudine thiab lamivudine. Nyob rau hauv sib piv, betulinic acid thiab nws cov derivatives muaj inhibitory cuam tshuam rau ntau hom DNA thiab RNA kab mob.

2.2.1. Kev tiv thaiv kab mob HIV

AIDS los ntawm HIV tau dhau los ua ib qho ntawm cov kab mob sib kis loj uas ua rau tib neeg noj qab haus huv. Tam sim no lees txais cov txheej txheem ntawm kev tawm tsam HIV yog nkag mus inhibitors, thim rov qab transcriptase inhibitors, proteolytic enzyme inhibitors, integrase inhibitors thiab maturation inhibitors. Feem ntau cov tshuaj tam sim no yog thim rov qab transcriptase inhibitors thiab proteolytic enzyme inhibitors, uas muaj qhov tsis zoo xws li tshuaj tiv thaiv. Hauv qhov sib piv, betulinic acid thiab nws cov derivatives ua los ntawm kev cuam tshuam cov theem kawg ntawm kab mob viral lub neej, uas cuam tshuam txog kev kis tus kab mob, kev loj hlob thiab kev loj hlob, thiab feem ntau yog siv los ua kev nkag mus thiab kev loj hlob inhibitors, uas yog cov tshiab HIV inhibitors los tsim. .

2.2.2. Inhibition ntawm cov kab mob RNA xws li mob npaws thiab kab mob siab C (HCV)

2.2.3 Inhibition ntawm hom kab mob DNA

2.3 Anti-inflammatory thiab analgesic teebmeem ntawm betulinic acid thiab nws derivatives

NF-κB yog ib lo lus generic rau ib pab pawg neeg ntawm cov kev hloov pauv hauv nuclear uas lub hom phiaj ntawm κB qhov chaw thiab muaj ntau lub luag haujlwm hauv kev tswj hwm cov noob caj noob ces ntawm ntau yam kev mob tshwm sim; thaum phospholipase A2 (PLA2) koom nrog cov txheej txheem pathogenic ntawm o thiab mob hnyav. Lub ntsiab anti-inflammatory mechanism ntawm kev txiav txim ntawm birch triterpenoids yog los ntawm inhibition ntawm NF-κB signaling txoj kev, suppressing cov noob thiab protein ntau theem ntawm nws downstream tswj inflammatory mediators; los yog los ntawm kev ua haujlwm los tiv thaiv PLA2, txhawb kev ua haujlwm ntawm nitric oxide synthase kom tsis txhob muaj ntau lawm, thiab kev txhawb nqa ntawm ROS los tsim oxidative kev nyuaj siab kom ua tiav lub hom phiaj tiv thaiv. Betulinic acid kuj tseem tuaj yeem ua tiav cov teebmeem analgesic los ntawm kev hloov kho NF-κB / calcium channel dual txoj cai.

2.4 Inhibition ntawm paj hlwb thiab cov hlab ntsha puas tsuaj los ntawm betulinic acid thiab nws cov derivatives

2.4.1. Kev ua haujlwm ntawm lub hauv nruab nrab paj hlwb

2.4.2. Modulation ntawm vascular puas thiab inhibition ntawm neuronal puas

2.4.3. Txhim kho dementia

Dementia yog ib qho mob ntawm qhov tsis txaus ntseeg ntawm kev puas siab puas ntsws ua haujlwm. Ob hom kev dementia feem ntau yog Alzheimer's kab mob thiab vascular dementia; Cov kev tshawb fawb tsis ntev los no tau pom tias betulinic acid tau qhia qee qhov kev txhim kho hauv ob qho tib si ntawm hom kev dementia.

2.5. Kev kho mob ntawm betulinic acid thiab nws cov derivatives ntawm lwm yam kab mob

2.5.1. Kev tiv thaiv ntawm cardiomyocytes

2.5.2. Lipid-regulating thiab hepatoprotective teebmeem

2.5.3. Antibacterial teebmeem

2.5.4 ib. Inhibition ntawm ntshav qab zib mellitus thiab nws cov teeb meem

3. Cov ntawv thov

Nws yog tsuas yog siv nyob rau hauv kws tshawb fawb teb raws li ib tug muaj peev xwm los tiv thaiv mob qog noj ntshav, nws kuj yuav siv tau nyob rau hauv cov tshuaj pleev ib ce.

4. Flow daim ntawv qhia

5. Tus Qauv Zoo

6. Txoj kev tsom xam

MOA muaj nyob rau thaum thov

7. Reference Spectrum

8. Kev ruaj ntseg thiab kev nyab xeeb

Kev ruaj ntseg:
Nyob ruaj khov nyob rau hauv cov xwm txheej zoo (chav kub). Cov Ntaub Ntawv Kev ruaj ntseg muaj nyob rau ntawm koj qhov kev thov.
Kev nyab xeeb:

Nws yog non-mutagenic, innocuous thiab tsis irratating, tsis muaj inflammatory prostaglandin tso tawm, tsis muaj nce nyob rau hauv cellular lysis, tsis muaj kev cuam tshuam rau cytokines. Muaj kev nyab xeeb rau kev tu tawv nqaij.

9. Cov neeg siv lus pom

10. Peb Daim Ntawv Pov Thawj

11.Peb cov neeg muas zaub

12. Exhibitions

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