Ammonium tetrathiomolybdateyog ib qho tshuaj uas muaj ntau yam kev ua haujlwm, feem ntau yog siv los kho cov kab mob los ntawm tooj liab.
Dab tsi yog cov haujlwm tseem ceeb thiab kev siv?
1. Kho Wilson tus kab mob
Ammonium tetrathiomolybdate txo qhov tsub zuj zuj ntawm tooj liab hauv lub cev los ntawm kev khi rau tooj liab thiab albumin hauv plasma los ua ib qho nyuaj uas cuam tshuam nrog kev nqus ntawm tooj liab hauv txoj hnyuv thiab txhawb kev tso zis ntawm tooj liab.
Cov kev tshawb fawb tau pom tias ammonium tetrathiomolybdate tuaj yeem txo qhov kev pheej hmoo ntawm kev puas tsuaj ntawm paj hlwb thaum pib kho thiab yog li suav tias yog ib qho tshuaj zoo tshaj plaws rau kev kho mob Wilson tus kab mob.
2. Muaj peev xwm kho cov kab mob metabolically ntsig txog fatty siab
Ammonium tetrathiomolybdate tau pom nyob rau hauv kev sim tshuaj kom txo qis daim siab qhov hnyav piv thiab cov qib ntshav transaminase, thaum txo tag nrho cov roj cholesterol thiab triglyceride hauv daim siab.
Qhov no qhia tau hais tias ammonium tetrathiomolybdate tuaj yeem muaj peev xwm kho tau rau cov kab mob metabolically txuam nrog fatty siab.
3. Kho mob raum raug mob los ntawm cisplatin
Ammonium tetrathiomolybdate plays lub luag haujlwm antioxidant los ntawm kev ua kom Nrf2 qhia txoj hauv kev hauv lub raum tubular epithelial hlwb, yog li txo qis cisplatin ua rau mob raum raug mob.
Qhov kev tshawb pom no muab cov tswv yim kho tshiab rau cisplatin-induced AKI.
Tej yam tsis zoo tshwm sim?
Cov teebmeem tsis zoo ntawm ammonium tetrathiomolybdate muaj xws li thim rov qab myosuppression, nce aminotransferase, mob siab mob siab, nce qib triglyceride thiab roj cholesterol, qaug dab peg, thiab ntshav qab zib cuam tshuam nrog tooj liab tsis txaus.
Mia
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