1.Minoxidil sulfateyog ib qho kev sib xyaw ua haujlwm uas ua haujlwm raws li cov poov tshuaj channel qhib, tshwj xeeb los ntawm kev ua kom ATP-sensitive potassium channels hauv vascular du leeg hlwb. Qhov kev ua kom no ua rau hyperpolarization ntawm cov cell membrane, uas nyob rau hauv lem inhibits calcium influx thiab ua rau so ntawm vascular du nqaij. Minoxidil sulfate muaj peev xwm dilate arterioles thiab txo peripheral vascular tsis kam. Cov txheej txheem ntawm kev ua haujlwm no yog vim nws lub peev xwm los txhawb vasodilation thiab nce ntshav txaus, ua rau nws muaj feem cuam tshuam hauv kev tshawb fawb tsom mus rau kev ua haujlwm ntawm lub plawv thiab kev tswj hwm. Ntawm qib molecular, minoxidil sulfate cuam tshuam nrog cov poov tshuaj raws los hloov kho lawv cov haujlwm, thaum kawg cuam tshuam rau vascular tone thiab kev tswj ntshav siab. Nws lub luag haujlwm hauv kev sim cov ntsiab lus suav nrog kev tshawb xyuas lub cev thiab cov tshuaj tshuaj ntawm vasodilators thiab lawv qhov cuam tshuam rau kev ua haujlwm ntawm lub plawv.
Minoxidil sulfate, lub zog thiab ATP-sensitive K + channel opener, yog sulfated metabolite ntawm minoxidil. Minoxidil sulfate yog suav tias yog vasodilator los txhawb cov plaub hau kev loj hlob hauv vivo, Nws yog siv los ua kom cov plaub hau loj hlob. tuaj yeem yaj ncaj qha rau hauv dej Qhov no ua rau nws yooj yim dua los tsim cov qauv ntau dua li cov qauv Minoxidil. Nws tuaj yeem siv pleev xim, siv rau ntawm tawv taub hau, lossis ua kev kho qhov ncauj. Hauv cov txiv neej, minoxidil sulfate txhawb kev loj hlob ntawm cov plaub hau, ua kom cov plaub hau ntom ntom, thiab ua rau cov plaub hau poob qis. Hauv cov poj niam, nws slows plaub hau thinning thiab poob thiab txhawb txoj kev loj hlob ntawm cov plaub hau tshiab.
2.Buhl AE thiab pab pawg tau ua pov thawj tias minoxidil sulfate yog cov khoom siv metabolite uas txhawb cov hauv paus plaub hau. Ib kauj ruam tseem ceeb hauv kev nkag siab txog minoxidil cov txheej txheem ntawm kev ua ntawm cov hauv paus plaub hau yog los txiav txim siab cov tshuaj ua haujlwm. Cov kws tshawb fawb tau siv lub cev-cultured vibrissa follicles kuaj seb nws puas yog minoxidil lossis nws cov sulfated metabolite, minoxidil sulfate, uas txhawb cov plaub hau kev loj hlob. Cov follicles los ntawm cov nas me nyuam mos tau raug coj los nrog lossis tsis muaj tshuaj thiab cov teebmeem raug soj ntsuam los ntawm kev ntsuas kev koom ua ke ntawm radiolabeled cysteine hauv cov plaub hau shafts ntawm cov follicles kho. Kev soj ntsuam ntawm minoxidil sulfotransferase kev ua tau qhia tias vibrissae follicles metabolize minoxidil rau minoxidil sulfate. Kev tshawb fawb txog koob tshuaj pom tau tias minoxidil sulfate yog 14 npaug ntau dua li minoxidil hauv stimulating cysteine incorporation hauv kab lis kev cai follicles. Peb cov tshuaj uas thaiv kev tsim cov tshuaj intrafollicular minoxidil sulfate tau sim rau lawv cov teebmeem ntawm kev siv tshuaj tua cov plaub hau. Diethylcarbamazine ua pov thawj tias yog ib qho tsis sib tw inhibitor ntawm sulfotransferase thiab tiv thaiv cov plaub hau kev loj hlob los ntawm minoxidil tab sis tsis yog los ntawm minoxidil sulfate. Inhibiting tsim ntawm intracellular PAPS nrog chlorate kuj thaiv qhov kev txiav txim ntawm minoxidil tab sis tsis yog minoxidil sulfate. Acetaminophen, muaj zog sulfate scavenger thaiv cysteine kev koom ua ke los ntawm minoxidil. Nws kuj tau thaiv follicular stimulation los ntawm minoxidil sulfate pom meej los ntawm ncaj qha tshem cov sulfate los ntawm cov tshuaj. Kev sim nrog lub zog minoxidil analog uas tseem tsim cov sulfated metabolite, pom tias nws cov haujlwm tau cuam tshuam los ntawm chlorate thiab diethylcarbamazine. Cov kev tshawb fawb no qhia tau hais tias sulfation yog ib kauj ruam tseem ceeb rau cov plaub hau loj hlob ntawm minoxidil thiab nws yog sulfated metabolite uas cuam tshuam ncaj qha rau cov plaub hau follicle.
Sales manager: Jessica shao
Skype: Sales6@pioneerbiotech.com
Email:Sales7@konochemical.com