Citicoline sodium feem ntau yog siv hauv kev kho mob los kho cov kab mob hauv lub paj hlwb uas tshwm sim los ntawm kev raug mob craniocerebral thiab cerebrovascular raug mob, thiab tuaj yeem siv rau kev kho mob Parkinson's syndrome, thiab muaj qee yam kev kho mob ntawm senile dementia; Kev kho mob ntawm cerebrovascular thiab kab mob plawv; lwm yam xws li ncua kev laus, txhim kho kev kawm thiab kev nco, thiab lwm yam kuj muaj qee yam kev kho mob. Txawm li cas los xij, kev txhaj tshuaj thiab cov hmoov qhuav qhuav qhuav tau siv rau hauv kev kho mob, uas tsis yooj yim rau kev rov qab los tom qab thiab kho cov kab mob hlwb. Rau cov neeg mob uas yuav tsum tau siv cov tshuaj rau lub sijhawm ntev, nws yog ib qho tseem ceeb heev rau kev tsim kho qhov ncauj yooj yim; Raws li cov ntaub ntawv soj ntsuam, cov kev tsis zoo tseem ceeb ntawm citicoline sodium yog cov tshuaj tiv thaiv kab mob hauv plab, xeev siab, mob plab, thiab mob plab. kev xav thiab lwm yam.
Citicoline hmoovyog ib qho tseem ceeb nruab nrab hauv biosynthesis ntawm cov qauv phospholipids hauv cell membranes. Exogenous kev tswj hwm ntawm citicoline tuaj yeem kho cov kab mob neuronal puas sai sai los ntawm kev ua kom cov phospholipid synthesis, txhawb acetylcholine thiab dopamine synthesis kom stabilize neurotransmitter systems, thiab txo cov tsub zuj zuj ntawm dawb fatty acids nyob rau hauv ischemic hlwb cov ntaub so ntswg kom txo tau cov ntaub so ntswg ntxiv kev puas tsuaj los ntawm nws. Lub sijhawm kho mob dav dav, muaj bioavailability siab, kev nkag mus rau cov ntshav-hlwb hauv hlwb zoo, thiab kev nyab xeeb zoo heev ua rau citicoline yog cov tshuaj tiv thaiv neuroprotective thiab neurorestorative zoo. Muaj pov thawj qhia tias citicoline txhim kho kev ua haujlwm ntawm lub paj hlwb hauv cov neeg mob uas mob stroke thiab subacute ischemic stroke.
Los ntawm kev txo cov cerebrovascular tsis kam thiab ua rau cov ntshav cerebral nce, nws tuaj yeem txhawb cov metabolism hauv hlwb thiab txhim kho cerebral ncig. Nws tseem tuaj yeem txhim kho kev ua haujlwm ntawm lub hlwb ascending reticular activation system, txhim khu kev ua haujlwm ntawm lub cev vertebral system, thiab txhim kho lub cev muaj zog tuag tes tuag taw, yog li nws muaj qee yam cuam tshuam rau kev txhawb nqa lub hlwb kev ua haujlwm thiab txhawb kev rov zoo. Kev txhaj tshuaj Citicoline sodium tuaj yeem nkag mus rau hauv cov ntshav sai sai tom qab txhaj tshuaj, thiab qee qhov ntawm nws nkag mus rau hauv cov ntaub so ntswg ntawm lub hlwb los ntawm cov ntshav-hlwb barrier. choline ib feem ua ib tug zoo methylation pub rau hauv lub cev, uas muaj peev xwm transmethylate ntau yam tebchaw. Kwv yees li 1 feem pua ntawm choline raug tso tawm hauv cov zis.
Lub luag haujlwm ntawm citicoline ua tus thawj coj rau phosphatidylcholine synthesis tau pom nyob rau hauv kev tshawb fawb tsiaj,
Exogenous choline tau pom tias tawg rau hauv choline thiab cysteine , uas tau pom tias yuav ua rau cov ntshav choline thiab uridin hauv tib neeg.
Hauv tib txoj kev tshawb nrhiav glycoside tau pom tias yuav hloov pauv ncaj qha rau CTP. Yog li ntawd, Citicoline yog hypothesized los txhawb cov hlab ntsha cell membrane noj qab haus huv los ntawm kev muab cov khoom tsim nyog rau phospholipid synthesis.
Exogenous citicoline kuj tau xav tias yuav pab khaws cov paj hlwb kev ncaj ncees los ntawm kev muab cov choline ntxiv, uas pab tiv thaiv degeneration ntawm cov paj hlwb thaum endogenous choline qib qis dhau.
Citicoline tau kawm raws li kev kho mob rau ischemic stroke. Thaum lub sij hawm ischemia, phosphatidylcholine tau tawg mus rau hauv cov rog dawb, uas tom qab ntawd hloov mus ua dawb radicals.
Exogenous citicoline yog xav kom ncua lossis tiv thaiv kev tawg ntawm phosphatidylcholine los ntawm kev tawm tsam ischemic.
Citicoline kuj tseem ua haujlwm hauv kev tsim cov membrane phospholipids hu ua sphingomyelin. Citicoline tau pom zoo los kho cov qib pre-stroke ntawm sphingomyelin hauv cov neeg mob uas tau ntsib kev mob stroke ischemic.
Yolanda
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