Spermidine muaj kev txhawj xeeb dav raws li qhov muaj peev xwm tiv thaiv kev laus. Nws tuaj yeem inhibit neuronal synthase, khi thiab precipitate DNA, kuj tuaj yeem siv los ua kom huv DNA-binding proteins, txhawb nqa T4 polynucleotide kinase kev ua haujlwm, thiab tiv thaiv hnub nyoog ntsig txog kev nco ploj thiab Alzheimer's kab mob. Nws kuj tseem hu ua "cov khoom ntawm cov hluas" vim hais tias spermidine yog cov muaj zog antioxidant thiab cov khoom noj tseem ceeb rau kev ua haujlwm autophagy ntawm cov hlwb hauv tib neeg lub cev, uas ua rau cov txheej txheem ntawm lub cev hu ua autophagy, lub ntuj kho thiab cov txheej txheem circulatory, Cov txheej txheem rov ua dua tshiab ntawm tes no ua lub luag haujlwm tseem ceeb hauv kev noj qab haus huv kev laus thiab tsis txhob muaj teeb meem txog hnub nyoog.Spermidine trihydrochlorideyog ib qho ntawm feem ntau siv ntsev daim ntawv ntawm spermidine.
Qhov concentration ntawm spermidine hauv lub cev txo qis nrog lub hnub nyoog ntawm cov tsiaj thiab tib neeg. Ib qho laj thawj tseem ceeb yog qhov kev ua ntawm polyamine-ua enzymes hauv lub cev raug txo. Hauv cov neeg laus feem ntau, qib spermidine tsawg. Txawm li cas los xij, hauv kev noj qab haus huv 90-cov hnub nyoog hnub nyoog thiab ib puas xyoo, spermidine hauv cov ntaub so ntswg tseem nyob nruab nrab hnub nyoog. Txoj kev tshawb no kuj pom tau hais tias nyob rau hauv cov teb chaws Es Xias, qhov ntau dua cov spermidine, lub zos lub neej expectancy yuav siab dua.
Xyoo 2009, kev tshawb fawb tau luam tawm nyob rau hauv "Nature" sub-journal "Cell Biology" tau qhib qhov kev tshawb fawb spermidine. Txoj kev tshawb no tau taw qhia tias spermidine tuaj yeem ua rau muaj kev hloov pauv ntawm cov noob caj noob ces, yog li txhim kho autophagy. , inhibiting cellular oxidative stress thiab necrosis, spermidine tau pom nyob rau hauv cov kev sim kom ncua lifespan nyob rau hauv poov xab, nematodes, thiab yoov. Thaum cov ntaub ntawv tshawb fawb tau tshaj tawm, nws tam sim ntawd ua rau muaj kev txhawj xeeb thoob plaws hauv zej zog.
Xyoo 2016, tus kws tshawb fawb Nyij Pooj Yoshinori Ohsumi tau txais txiaj ntsig Nobel nqi zog hauv Physiology thiab Tshuaj rau nws "kev tshawb pom ntawm cov txheej txheem ntawm autophagy", yog li lees paub cov txheej txheem ntawm autophagy hauv hlwb.
Lub autophagy mechanism yog ib qho txheej txheem ntawm kev rov ua dua tshiab ntawm tes thiab kev tiv thaiv. Nws tuaj yeem tsis tsuas yog tshem tawm cov kab mob invading thiab kab mob, tab sis kuj cuam tshuam rau txoj kev loj hlob ntawm embryos thiab cell mutation. Nws tseem tuaj yeem tshem tawm cov protein thiab cov organelles puas, thiaj li ua kom lub cev lub cev muaj zog tag nrho. Kev ua kom cov spermidine hauv autophagy pom tseeb ua rau nws tseem ceeb dua.
Tsis muaj kev tsis ntseeg tias spermidine qhov kev pab cuam rau kev noj qab haus huv mus deb dhau qhov ntawd. Thaum Lub Ib Hlis Ntuj xyoo 2018, cov ntawv xov xwm sab saum toj "Science" tau luam tawm ib daim ntawv blockbuster ntawm spermidine, uas tau sau ntau tshaj 130 kev tshawb fawb kev kawm nyob rau xyoo tas los no, thiab tau taw qhia txog ntau yam teebmeem ntawm spermidine, uas suav nrog kev tiv thaiv kev laus, kev tiv thaiv kab mob plawv, anti-cancer, neuromodulation thiab neuroprotection, metabolic kab mob txhim kho, thiab lwm yam.
Hauv tib neeg lub cev, spermidine muaj 3 qhov chaw tseem ceeb.
Thawj tus yog synthesized los ntawm tib neeg lub cev nws tus kheej, uas tuaj yeem yog los ntawm arginine mus rau ornithine rau putrescine rau spermidine; nws kuj tuaj yeem hloov los ntawm cov phev.
Qhov thib ob yog los ntawm cov khoom noj ncaj qha.
Qhov kawg yog muab los ntawm cov synthesis ntawm plab hnyuv flora.
Kev noj cov spermidine precursors tuaj yeem nce qib spermidine; ob qho tib si arginine thiab phev tuaj yeem ua rau nws cov teebmeem. Cov khoom noj uas nplua nuj arginine feem ntau yog txiv ntoo, noob thiab taum thiab nqaij qaib ntxhw. Cov zaub mov nplua nuj nyob hauv cov phev muaj xws li hom qoob mog, nqaij qaib siab, nqaij qaib lub siab, thiab nqaij nyug hnyuv.
Nws tsim nyog sau cia tias kev tswj hwm kev noj qab haus huv methylation kuj tseem ceeb rau spermidine synthesis. Lub synthesis ntawm spermidine yuav tsum muaj kev koom tes ntawm dcSAMe, uas yog muab los ntawm SAMe. SAMe yog qhov tseem ceeb tshaj plaws coenzyme hauv tib neeg methylation, thiab nws qib cuam tshuam los ntawm lub voj voog methylation.
Tau kawg, txoj kev ncaj tshaj plaws yog kom tau txais spermidine trihydrochloride los ntawm cov khoom noj. Cov zaub mov nplua nuj nyob hauv spermidine feem ntau yog cov ntsiab lus ntawm cov nroj tsuag thiab tsiaj txhu, xws li cov kab mob nplej, taum, noob, qwj thiab tsiaj lub siab (ntawm chav kawm, cov kab mob nplej muaj gluten).
Spermidine yog ib yam khoom uas ua raws li kev txwv caloric, muab cov txiaj ntsig zoo ib yam li kev yoo mov. Kev noj cov spermidine tuaj yeem pab nrog cov kab mob metabolic, neurodegeneration, kab mob plawv, thiab mob qog noj ntshav, thiab nws kuj muaj peev xwm txhawb nqa lub neej ntev. Kev sim ua ntej hauv vitro qhia tias spermidine kuj tseem tuaj yeem txhawb cov plaub hau kev loj hlob. Txhawm rau nce qib spermidine hauv koj lub cev, noj cov zaub mov uas muaj arginine, spermine, thiab spermidine.
Flavia
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