Hydroxocobalaminyog qhov ruaj khov nyob hauv tib neeg lub cev. Txawm hais tias nws yog hydrolyzed thiab metabolized los ntawm qee cov enzymes, nws tseem ua nws cov homologous tshuaj.
Qhov ncauj cov vitamins B12 muaj ntau ntau yam, suav nrog Mecobalamin ntsiav tshuaj, mecobalamin tsiav tshuaj, adenosine cobalamin ntsiav tshuaj, thiab lwm yam.
Mecobalamin, adenosylcobalamin, cyanocobalamine thiab hydroxocobalamin yog txhua yam vitamin B12.
Vim tias tib neeg pom thawj zaug yog cyanocobalamin, yog li tam sim no nws hu ua vitamin B12. Qhov tseeb, qhov no yog yuam kev. Tam sim no pom tseeb tias B12 uas tuaj yeem siv ncaj qha los ntawm tib neeg lub cev yog hydroxocobalamin thiab cobamamide adenosine. Txawm hais tias koj siv cyanocobalamin, nws yuav tsum hloov mus rau hauv hydrocobalamin lossis cobalamin hauv hlwb los koom hauv tib neeg lub neej
Cov tshuaj pharmacokinetics ntawm hydroxycobalamin nyob rau hauv tib neeg lub cev tsis tau pom dav dav, thiab cov ntaub ntawv tshawb fawb uas twb muaj lawm qhia tau hais tias muaj qee yam tseem ceeb hauv ib leeg txawv. Cov txiaj ntsig ntawm kev sim tshuaj rau ib tus neeg mob nrog kev haus luam yeeb tau qhia tias tom qab ib koob 5g, cov tshuaj hydroxycobalamin qhov kev txiav txim siab tau txiav txim siab, thiab cov ntaub ntawv pharmacokinetic soj ntsuam tau 6 hnub yoog nrog ob lub qauv sib piv. Cov txiaj ntsig ntawm qhov pom meej faib ntim pom tau hais tias cov tshuaj tau muab faib tawm sab nraud lub cell. Kev faib tawm ib nrab-lub neej yog (1.89 ± 0.34) h, kev tshem tawm ib nrab-lub neej yog (26.2 ± 2.7) h, cov ntim faib tau yog (0.45 ± 0.03) l · kg ~, lub raum tshem tawm qhov siab yog (0.31 ± 0.06) l · H ~, thiab tag nrho kev tshem tawm tus nqi yog (0.83 ± 0.07) l · H.
Cov kev mob tshwm sim ntawm hydroxocobalamin ua pob liab liab, tsis qab los noj mov, xeev siab, ntuav thiab raws plab.
Thov hu rauinfo@konochemical.comyog tias xav tau cov ntaub ntawv ntxiv.
