Rosmarinic acidyog polyphenol zoo ib yam li caffeic acid (pom hauv kas fes), uas muaj cov roj perilla ntau ntau .Nws yog cov antioxidant ntau thiab kev noj qab haus huv tshuaj thiab suav tias yog qhov muaj txiaj ntsig zoo rau kev noj qab haus huv.Nws qhia cov tshuaj antioxidant thiab anti-inflammatory teebmeem thiab tuaj yeem tiv thaiv ntau yam hom mob cancer. Tsis tas li ntawd xwb, thaum nws nyob hauv ethanol matrix (feem ntau yog Perilla Caw), nws tuaj yeem nqus tau los ntawm daim tawv nqaij.
Kev tswj xyuas qhov ncauj ntawm cov roj perilla (cov nas) tau pom tias inhibit kev tsis haum tshuaj los ntawm 43% ntawm qhov ncauj ntawm 500 mg / kg. Tom qab ntawd, hauv kev tshawb nrhiav tib neeg ntawm 30 tus neeg muaj hnub nyoog 21-53 muaj mob me me cedar fab (mob ntswg thaum lub caij ua xua), 50 mg, 200 mg rosmarinic acid lossis placebo tau nrog rau noj tshais rau 21 hnub. Rosmarinic acid zoo li ua tau zoo rau kev txwv kev tsis haum tshuaj raws kev siv tshuaj, nrog 30% ntawm cov placebo pawg qhia kev zam, thaum 55.6% ntawm 50 mg thiab 70 mg pawg qhia txog kev kho mob. Cov ntaub ntawv pov thawj xub pib qhia tias kev noj rosmarinic acid ib hnub ib zaug zoo li yuav pab tib neeg ua xua.
Rosmarinic acid tau ua pov thawj muaj cov antioxidant ntxim rau superoxide dawb radical thiab hydroxyl dawb radical nyob rau hauv vitro.Nws tseem tuaj yeem tiv thaiv qhov oxidation ntawm LDL lwg me me thiab koom tes nrog lycopene hauv no nam.Rosmarinic acid (10, 25 lossis 50 mg / kg) tau muab cov ncauj lus ib hnub ib zaug rau ob hnub, 6 teev tom qab txhaj CCl4. Rosmarinic acid nws tus kheej tsis hloov lub siab lub cev (tsis zoo lossis tus kwv tij lub cev hnyav) thiab ALT qib, tab sis tom qab CCl4, tus qauv tsis mob siab lub cev hnyav ntawm 50 mg / kg nce txog 56% (tsuas yog 26% piv rau lub cev hnyav), thiab cov tus nqi siab ntawm ALT nqis qis dua 23%. Txo cov nplooj siab necrosis thiab fibrosis cuam tshuam nrog rosmarinic acid tau tshaj tawm.
Rosmarinic acid (feem ntau los ntawm perilla roj) yog siv tshuaj pleev los tua mob qog nqaij daim tawv. Qhov no tau qhia hauv nas ua qauv.Thaum nas, rosmarinic acid tuaj yeem nqus tau los ntawm daim tawv nqaij. Cov tsub zuj zuj ntawm rosmarinic acid yog txiaj ntsig rau kev xaum tawv nqaij, nqaij thiab pob txha.
Kev sib cuam tshuam ntawm rosmarinic acid nrog o thiab tshuaj tiv thaiv kab mob yog tau kawm vim nws yog ib feem ntawm cov roj perilla, thiab cov roj zaub tau muab los ntawm (Perilla frutescens), uas yog ib feem tseem ceeb ntawm suav tshuaj (tsoos Japanese) thiab tau ua pov thawj rau zoo tiv thaiv kev fab tshuaj.Thaum kuaj ntshav hauv los ntawm kev kuaj ntshav ntawm edema, rosmarinic acid inhibited cov lus teb ntawm tPA (tus neeg sawv cev tiv thaiv kab mob) thiab tseem pom tias qhov txo qis hauv TPA vim kev tiv thaiv oxidative nce.
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