Scutellaria hauv paus Extract CAS 21967-41-9

1. Taw qhia
Baicalin yog ib qho flavonoid cais los ntawm cov cag qhuav ntawm Scutellaria baicalensis Georgi. Cov kev tshawb fawb pharmacological ntawm Scutellaria baicalensis tau lees paub tias cov khoom xyaw nquag hauv Scutellaria baicalensis cov hauv paus hniav feem ntau yog flavonoids, thiab ntau dua 40 flavonoids tau txheeb xyuas, xws li Baicalin, Baicalein, Beta-d-glucopyranosiduronic acid thiab Wogonin. Baicalin yog ib qho ntawm ntau tshaj plaws flavonoids los ntawm scutellaria cag extract thiab tau raug sau tseg kom muaj ntau yam kev siv, suav nrog tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tiv thaiv kab mob thiab tiv thaiv kev tiv thaiv kab mob, plab zom mov thiab paj hlwb.

2. Lub luag haujlwm tseem ceeb
2.1. Antioxidant
Baicalin yog ib qho antioxidant zoo thiab tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv oxidative tshwm sim los ntawm oxygen radicals xws li superoxide anion thiab catalase. Lub ntsiab mechanism ntawm nws cov nyhuv antioxidant yog nyob rau hauv: a. Cov qauv txiav txim siab txog kev ua haujlwm, Baicalin cov qauv tshuaj muaj ntau pawg phenolic hydroxyl (saib daim duab 1), phenolic hydroxyl pawg hnov ​​​​mob nrog dawb radicals los tsim ntau ruaj khov semi-quinone radicals, yog li tshem tawm cov dawb radical saw cov tshuaj tiv thaiv thiab tiv thaiv qhov tshwm sim ntawm vicious cycle reactions. ; b. Baicalin tuaj yeem tiv thaiv qhov tshwm sim ntawm lub voj voog tsis zoo los ntawm kev tswj hwm kelch-zoo li ECH-txog protein 1 (Keap1) thiab ubiquitin linker protein (cullin E3, cul3) qhia, nce autophagy protein (protein 62, p62) qhia, qhib Nrf2. antioxidant signaling pathway, uas nyob rau hauv lem cuam tshuam cov transcription ntawm antioxidant protein teb cov ntsiab lus, tswj superoxide dismutase (SOD), catalase (CAT), heme oxygenase 1 (HO-1), organismal glutathione (Kev qhia ntawm SOD, CAT, heme oxygenase 1 (HO-1), GSH thiab NAD(P)H: quinone oxidoreductase 1 (NQO1) yog tswj kom tshem tawm cov dawb radicals ntau dhau hauv cov hlwb thiab tiv thaiv lawv los ntawm kev puas tsuaj hauv hypoxia / reoxygenation. Hauv kev xaus, Baicalin tsis tsuas yog tshem tawm cov dawb radicals nyob rau hauv cov saw pib theem ntawm cov tshuaj tiv thaiv antioxidant, tab sis kuj ncaj qha ntes cov dawb radicals nyob rau hauv cov dawb radical cov tshuaj tiv thaiv saw, thaiv cov dawb radical cov tshuaj tiv thaiv thiab ua si ob lub luag hauj lwm ntawm kev tiv thaiv thiab saw tawg.

2.2 Anti-microbial
Scutellaria cag extract baicalin muaj ntau yam kab mob tua kab mob thiab muaj zog tiv thaiv Staphylococcus aureus thiab Pseudomonas aeruginosa. Qhov qis tshaj inhibitory concentrations ntawm baicalin thiab sulfamethoxazole (SMZ-TMP) tiv thaiv cov tshuaj tiv thaiv Staphylococcus aureus yog 2 mg / ml thiab 0.45 mg / ml, raws li, thiab hauv vivo kuaj pom tias baicalin (100 mg / kg) tuaj yeem txo qhov kev tuag ntawm cov tshuaj tiv thaiv Staphylococcus aureus-mob nas, qhia tias baicalin muaj cov nyhuv inhibitory ntawm cov tshuaj tiv thaiv Staphylococcus aureus. Baicalin muaj cov tshuaj tua kab mob ntawm cov tshuaj tiv thaiv S. aureus.
Baicalin ua raws li cov tshuaj tiv thaiv kab mob hauv ntau txoj hauv kev (saib daim duab), suav nrog kev ua kom lub cev tiv thaiv kab mob, tiv thaiv kev tsim biofilm, txo cov kab mob inflammatory, kev puas tsuaj ntawm cov kab mob phem, inhibition ntawm cov kab mob enzymes, txo cov kab mob endotoxins, thiab txo cov tshuaj tiv thaiv.
Cov kev tshawb fawb tam sim no tau pom tias baicalin muaj qhov cuam tshuam rau cov kab mob Gram-positive thiab Gram-negative. Piv txwv li, nyob rau hauv bovine mastitis tshwm sim los ntawm E. coli, baicalin adheres rau lub cell phab ntsa ntawm E. coli, txo cov stability ntawm cov kab mob thiab nce permeability ntawm phab ntsa cell, thaum kawg ua rau cov kab mob tuag.

2.3 Anti-inflammatory thiab immunomodulatory
Ntawm tag nrho cov physiological teebmeem ntawm baicalin, anti-inflammatory thiab immunomodulatory teebmeem tshwj xeeb tshaj yog. Baicalin tau qhia meej txog kev tiv thaiv kab mob thiab kev tiv thaiv kab mob hauv ntau yam tsiaj cov qauv ntawm o thiab autoimmunity, xws li: mob hawb pob, mob pancreatitis, mob ntsws mob, mob siab mob, mob siab, mob plab, hnub ci dermatitis, sim periodontitis thiab sim autoimmune encephalomyelitis. baicalin kev tswj hwm hauv vivo feem ntau txo qis cov ntaub so ntswg puas tsuaj thiab txo qis cov ntshav plasma pro-inflammatory cytokine qib (TNF-, IL-1, IL-6, thiab lwm yam) hauv cov qauv Nws kuj hloov kho qhov tso tawm ntawm cytokines xws li raws li interferon, IL-4 thiab IL-10 los ntawm qee lub cev tiv thaiv kab mob los tiv thaiv cov teebmeem.

2.4 Kev tiv thaiv kev raug mob ntawm daim siab
Tus qauv nas ntawm lub siab raug mob tau npaj siv CCl4 thiab D-galactose, thiab cov dej num ntawm cov ntshav aspartate aminotransferase thiab alanine aminotransferase raug ntsuas los ntawm kev tshuaj ntsuam colorimetric; Kev ua ub no ntawm serum superoxide dismutase, glutathione peroxidase thiab malondialdehyde raug ntsuas. Cov txiaj ntsig tau pom tias baicalin txo qis qhov nce siab ntawm serum aspartate aminotransferase (ALT) thiab alanine aminotransferase (AST) hauv cov nas uas muaj lub siab raug mob los ntawm CCl4 thiab D-galactose, thiab nce kev ua haujlwm ntawm serum superoxide dismutase (SOD) thiab glutathione. peroxidase (GSH-Px) nyob rau hauv nas nrog mob siab mob siab. Cov txiaj ntsig tau pom tias baicalin muaj qhov nce ntxiv hauv kev ua haujlwm ntawm serum superoxide dismutase (SOD) thiab glutathione peroxidase (GSH-Px) thiab txo cov ntsiab lus ntawm malondialdehyde (MDA). Cov txiaj ntsig tau pom tias baicalin muaj cov txiaj ntsig tiv thaiv mob siab mob siab los ntawm CCl4 thiab D-galactose hauv cov nas. Hauv kev sim, SOD thiab GSH-Px tau nce ntxiv thiab MDA tau txo qis hauv pawg tswj hwm piv rau pawg qauv, qhia tias hepatoprotective mechanism ntawm baicalin yog ze rau nws lub peev xwm los tawm tsam dawb radical lipid peroxidation.

2.5 Ameliorating nyhuv ntawm ntshav qab zib nephropathy
Mob ntshav qab zib nephropathy (DN) yog ib qho ntawm cov teeb meem microvascular feem ntau ntawm cov ntshav qab zib mellitus (DM), thiab kev kawm txog nws cov kab mob tau ua lub ntsiab lus kub hauv kev kho mob ntshav qab zib hauv tsev thiab txawv teb chaws. Hyperglycemia yog qhov pib ua rau mob ntshav qab zib nephropathy, thiab dhau los ntawm cov txheej txheem hauv cov leeg, nws tuaj yeem ua rau oxidative kev nyuaj siab thiab o hauv cov leeg, ua rau ua rau lub zos cytokine network hauv ob lub raum thiab ua rau DN. Angiotensin II yog qhov tseem ceeb tshaj plaws hauv cov kab ke no thiab feem ntau ze rau DN. Tom qab kev kho mob baicalin, Ang II tau rov qab zoo dua, uas yog lub hom phiaj ntawm baicalin tiv thaiv lub raum ua haujlwm hauv DN nas, piv txwv li baicalin kho lossis tiv thaiv lub raum ua haujlwm hauv DN nas los ntawm kev txo qis kev ua haujlwm ntawm renin-angiotensin system (RAS) hauv hyperglycaemic. xeev. Tsis tas li ntawd, baicalin txo qis AngII thiab kho lub raum ua haujlwm los ntawm kev txo cov ntshav siab thiab intra-glomerular siab thiab txhim kho cov ntshav ib puag ncig thiab ncig.

3. Cov ntawv thov

Scutellaria cag extract baicalin feem ntau yog siv hauv kev kho mob thiab kev lag luam tshuaj.

4. Flow Chart

5. Tus Qauv Zoo

Raws li Enterprise Standard

6. Txoj kev tsom xam

MOA muaj nyob rau thaum thov.

7. Reference Spectrum

8. Kev ruaj ntseg thiab kev nyab xeeb

Kev ruaj ntseg:

Nyob ruaj khov nyob rau hauv cov xwm txheej zoo (chav kub). Cov Ntaub Ntawv Kev ruaj ntseg muaj nyob rau ntawm koj qhov kev thov.
Kev nyab xeeb:

Raws li GARS (Feem ntau Pom Zoo Raws Li Kev Nyab Xeeb) Daim Ntawv Ceeb Toom ntawm Teb Chaws Asmeskas, nws muaj kev nyab xeeb rau tib neeg siv.

9. Cov neeg siv lus pom

10. Peb Daim Ntawv Pov Thawj

11. Peb Cov Neeg Siv Khoom

12. Exhibition

Cim npe nrov: scutellaria cag extract cas 21967-41-9, manufacturers, lwm tus neeg, Hoobkas, lag luam wholesale, yuav, nqe, zoo tshaj plaws, tej, kev muag khoom