Palmitoylethanolamide (PEA) Cas544-31-0

Taw qhia

Palmitoylethanolamide (PEA) Cas544-31-0 yog ib qho fatty acid nyob rau hauv amide, ib feem ntawm cov chav kawm ntawm nuclear agonists. PEA ntseeg tau tias yuav tswj hwm lub cev sib npaug los ntawm kev tswj hwm qhov kev rov ua haujlwm ntawm cov txheej txheem inflammatory, yog li tswj cov kab mob neuroinflammation, thiab pab tiv thaiv thiab txhim kho cov tsos mob ntawm cov kab mob neurodegenerative (xws li Alzheimer's disease). PEA muaj cov tshuaj tiv thaiv kab mob, tshuaj tua kab mob thiab cov tshuaj tiv thaiv neuroprotective.

PEA tau pom tias khi rau ib qho receptor nyob rau hauv lub cell-nucleus thiab exerts ib tug ntau yam ntawm lom functions uas muaj feem xyuam rau mob thiab o. Lub hom phiaj yog xav tias yog peroxisome proliferator-activated receptor alpha (PPAR- ). Tab sis lub xub ntiag ntawm PEA (thiab lwm yam muaj feem xyuam nrog N-acylethanolamines) tau paub los txhim kho kev ua haujlwm anandamide .

Cetylamide ethanol (PEA) yog endogenous fatty acid amide uas ib txwm muaj nyob rau hauv tib neeg cov ntaub so ntswg, nrog rau lub hauv paus paj hlwb. PEA tau pom tias khi rau nuclear receptors (nuclear receptors) thiab ua rau ntau yam mob, mob ntev txog kev ua haujlwm lom neeg.

PEA ua haujlwm los ntawm kev hloov pauv cov lus qhia ntawm qee cov noob los txo cov teeb meem inflammatory, nrog rau lwm yam kev ua kom muaj zog ua kom muaj zog - lub peev xwm los txhawb cov teeb liab los ntawm cannabinoid receptors hauv lub paj hlwb.

Ntau qhov kev tshawb fawb soj ntsuam tau pom tias PEA muaj cov tshuaj tiv thaiv kab mob, tiv thaiv kev hnov ​​​​lus, neuroprotective, thiab cov khoom siv tshuaj tiv thaiv kab mob; PEA tuaj yeem tswj hwm ntau cov txheej txheem physiological, suav nrog kev hnov ​​​​mob, convulsions, thiab neurotoxicity.

Qhov chaw

PEA yog tsim los ntawm tib neeg lub cev. Cov ntsiab lus ntawm cov khoom noj ntawm PEA txawv ntawm 950.000 ngg−1 nyob rau hauv soybean lecithin rau 0.25 ng g-1 hauv mis nyuj. Nws kuj pom muaj nyob rau hauv qe yolks thiab txiv laum huab xeeb. Cov khoom noj tseem ceeb ntawm palmitoylethanolamide (PEA) [1] (Daim duab 2)

PEA (Cetylamide Ethanol) yog ib feem ntawm cov taum pauv, cov protein, thiab qe qe. Nws raug suav hais tias muaj cov txiaj ntsig zoo sib xws rau CBD thiab yog qhov kev lees paub raug cai hloov pauv tau zoo. Piv txwv li, Gencor Pacific's PEA cov khoom lag luam muaj npe Levafen ntxiv tau pom zoo los ntawm Australian Therapeutic Supplies Authority, Indian Food Safety Authority, Canadian Natural Health Products Authority, thiab Brazilian Health Regulatory Authority. Xyoo tas los, nws tau muag los ntawm Hollan & Barrett hom los ntawm Vitaboost cov khoom. Tam sim no, nws tseem tuaj yeem yuav cov khoom lag luam cuam tshuam los ntawm Australia's Metanic.

Kev noj tshuaj

Feem ntau cov kev tshawb fawb soj ntsuam uas qhia txog kev txo qhov mob ntev tau siv ultrafine PEA ntawm koob tshuaj 600mg ob zaug ib hnub.

Metabolic pathways thiab molecular lub hom phiaj ntawm PEA

Hauv cov tsiaj, PEA biosynthesis ua tiav los ntawm hydrolysis ntawm nws tam sim phospholipid precursor, N-palmitoyl-phosphatiyl-ethanolamine, los ntawm kev ua ntawm N-acyl-phosphatiyl-ethanolamine-xaiv phospholipase D (NAPE-PLD) ntawm (Okamoto et al. 2004) (Fig. 1A). Kev degradation ntawm PEA rau palmitic acid thiab ethanolamine tshwm sim los ntawm kev ua ntawm ob hom hydrolases, fatty acid amide hydrolase (FAAH) (Cravatt li al., 1996), thiab tshwj xeeb tshaj yog, N-acyl ethanolamine hydrolyzing acid amidase (NAAA) (Ueda) et al., 2001) (Fig. 1A). Interestingly, biosynthesis thiab degradation ntawm PEA, nrog rau lwm yam N-acylethanolamines nyob rau hauv cov nroj tsuag, uas ua hauj lwm txawv physiological functions, tshwm sim los ntawm tib txoj kev thiab feem ntau zoo sib xws enzymes (Blancaflor li al., 2014). (daim duab 3)

PEA yog biosynthesized los ntawm daim nyias nyias phospholipid N-palmitoylphosphatidylethanolamine (NPPE) los ntawm ntau txoj hauv kev, qhov kev tshawb fawb feem ntau yog los ntawm kev ncaj qha hydrolysis ntawm NAPE, uas tuaj yeem degraded rau palmitic acid thiab ethanolamine los ntawm FAAH lossis NAAA (Iannotti li al., 2. ).

PEA tuaj yeem qhib ncaj qha PPAR- (Lo-Verme et al., 2005b) lossis, ntau qhov tsis sib haum xeeb, GPR55 (Ryberg et al., 2007).

PEA, piv txwv li los ntawm inhibiting qhov kev qhia ntawm FAAH, tuaj yeem nce qib endogenous ntawm AEA thiab 2-AG, uas ncaj qha qhib CB2 (los yog CB1) receptors thiab TRPV1 raws (ib puag ncig) (Di Marzo li al., 2001; Petrosino et al., 2016a).

PEA tuaj yeem txhim kho kev ua kom muaj zog thiab txo qis ntawm TRPV1 channels los ntawm AEA thiab 2-AG (kev cuam tshuam ib puag ncig) los ntawm allosteric modulation ntawm TRPV1 channels (De Petrocellis li al., 2001; Di Marzo li al., 2001; Ho et al., 2008; Petrosino et al., 2016a). PEA tseem tuaj yeem qhib TRPV1 raws los ntawm PPAR- (Ambrosino li al., 20132014). NAT, N-acyl

Main Function

Palmitoylethanolamide(PEA) Cas544-31-0 tau pom tias muaj cov tshuaj tiv thaiv kab mob, tiv thaiv kev tiv thaiv kab mob, neuroprotective, thiab tshuaj tiv thaiv kab mob.

Cov kab mob neurodegenerative, xws li Alzheimer's kab mob (ad), Parkinson's disease (PD), ntau yam sclerosis (MS) thiab amyotrophic lateral sclerosis (ALS), yog tus cwj pwm los ntawm kev maj mam thiab xaiv neuronal Cell tuag, ua rau qeeb thiab nce zuj zus ntawm ib lossis ntau dua. paj hlwb ua haujlwm. Nyob ntawm seb hom kab mob twg, kev puas tsuaj ntawm neuronal tuaj yeem ua rau kev paub tsis meej, dementia, kev coj tus cwj pwm tsis zoo, kev txav tsis zoo, lossis tuag tes tuag taw.

Cov teebmeem neuroprotective muaj peev xwm ntawm PEA tau pom nyob rau hauv ntau qhov kev sim ua qauv ntawm AD. Nyob rau hauv tus qauv nas, txhaj tshuaj subcutaneous ntawm cov compound txo tus cwj pwm tsis zoo, lipid peroxidation, inducible nitric oxide synthase (iNOS) induction, thiab cysteine ​​Aspartase -3 ua kom (D'Agostino li al., 2012). Tsis tas li ntawd, PPAR- agonist GW7647 tau tsim cov teebmeem zoo ib yam li PEA, uas ua tsis tau zoo los tiv thaiv A 25-35-induced memory deficits in PPAR- KO nas (D'Agostino et al., 2012).

Cov nyhuv neuroprotective ntawm PEA kuj tau pom nyob rau hauv cov tsiaj qauv ntawm PD uas muaj kev txhaj tshuaj intraperitoneal ntawm neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) ) (Esposito et al., 2012). Hauv particular, kev kho mob ntev nrog PEA (ip) tiv thaiv kev poob ntawm nigrostriatal neurons, hloov kev qhia ntawm microtubule-sociated proteins (MAP-2 thiab S100), ua kom cov astrocytes, thiab MPTP-induced Qhia ntawm iNOS protein (Esposito li al., 2012). Tsis tas li ntawd, PEA txo MPTP-txuas nrog kev coj cwj pwm tsis zoo thiab lub cev muaj zog (Esposito li al., 2012). Cov teebmeem no nyob ntawm qhov ua kom PPAR-, raws li kev tshuaj ntsuam genetic ablation ntawm no receptor exacerbates MPTP-induced neurotoxicity (Esposito li al., 2012).

Ua ke, cov kev tshawb pom no pab txhawm rau txheeb xyuas cov txheej txheem molecular uas PEA muaj peev xwm tswj hwm kev hloov pauv ntawm AD lossis PD-txuas nrog cov proteins thiab txo qis kev ua kom muaj cov cim pro-apoptotic thiab cov teeb meem pro-inflammatory, ua rau cortical thiab hippocampal neurons hauv AD. los yog PD. poob ntawm substantia nigra neurons. Yog li, PPAR- yog lub hom phiaj tseem ceeb rau cov teebmeem neuroprotective ntawm PEA hauv CNS, thiab cov pov thawj no tau txais kev txhawb nqa los ntawm PPAR- agonists thiab antagonists, uas coj los yog thaiv cov teebmeem ntawm PEA, raws li.

Ischemic stroke thiab mob hlwb raug mob

PEA tseem ua lub luag haujlwm tiv thaiv kab mob hauv lub paj hlwb los ntawm ischemic stroke thiab traumatic hlwb raug mob (TBI). Ischemic stroke yog ib yam kab mob uas tshwm sim los ntawm kev txo qis hauv cov ntshav mus rau lub hlwb uas ua rau muaj kev txwv tsis pub muaj oxygen, ua rau lub hlwb tuag. Nyob ntawm seb thaj chaw twg ntawm lub hlwb raug cuam tshuam, mob stroke tuaj yeem ua rau tuag tes tuag taw, hais lus tsis zoo, thiab tsis nco qab. Raws li yav dhau los tau piav qhia hauv cov neeg mob MS, nws tau pom tias hauv cov neeg mob hemispheric stroke, PEA qib kuj tau nce hauv cov ntaub so ntswg uas nyob ib puag ncig tus mob ischemic thawj (Schabitz li al., 2002), tom qab focal cerebral ischemia, PEA cov ntsiab lus kuj nce ntxiv hauv cov neeg mob MS. nas cerebral cortex (Franklin li al., 2003) (Table 2). Tsis tas li ntawd, tom qab ntawd nws tau tshaj tawm tias nyob rau hauv cov ntshav ntawm cov neeg mob mob stroke, PEA qib tau cuam tshuam nrog NIH stroke qhab nia (Naccarato li al., 2010). Xav txog cov kev tshawb pom no, cov peev txheej neuroprotective ntawm PEA tau tshawb xyuas hauv cov qauv kev sim ntawm ischemic stroke. Tshwj xeeb, nws tau pom tias tom qab lub sijhawm nruab nrab ntawm lub paj hlwb occlusion (tMCAO) nyob rau hauv cov tsiaj qauv ntawm mob stroke, thaum PEA tau tswj hwm exogenously (ip), PEA txo qis infarcts nyob rau hauv lub cortex thiab tag nrho infarct cheeb tsam piv nrog tswj cheeb tsam (Schomacher thiab al., 2008; Ahmad et al., 2012a), thaiv astrocyte infiltration thiab activation, txo pro-inflammatory marker qhia thiab txhim kho neurobehavioral muaj nuj nqi los ntawm kev saib xyuas lub cev muaj zog (Ahmad li al., 2012a).

Tsis ntev los no, nws tau tshaj tawm tias qhov qis dua ntawm co-ultraPEALut muaj peev xwm tsim tau tib yam neuroprotection tom qab tMCAO piv nrog PEA ib leeg (Caltagirone li al., 2016). Qhov tseem ceeb, kev tswj hwm ntawm co-ultraPEALut nyob rau hauv ib pawg ntawm 250 tus neeg mob stroke tau txhim kho tag nrho cov kev kho mob tsis zoo (piv txwv li, cov xwm txheej hauv paj hlwb, spasticity, kev paub, mob, thiab kev ywj pheej hauv kev ua neej nyob txhua hnub) tom qab 30 hnub ntawm kev kho mob (Caltagirone li al., 2016. ).

Cov kev tshawb fawb no qhia tias cov qib siab ntawm PEA feem ntau cuam tshuam nrog cov hlab ntsha raug mob tuaj yeem sawv cev rau kev tiv thaiv kev tiv thaiv thiab kev tswj hwm ntawm PEA ib leeg los yog ua ke nrog luteolin tuaj yeem muab kev kho mob los ntawm ib qho tseem tsis tau kawm txog cov txheej txheem los tiv thaiv qhov kev puas tsuaj no.

PEA thiab kev nkag siab qhov mob

Thawj txoj kev tshawb fawb qhia txog lub peev xwm ntawm PEA los tsim cov tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob hnub rov qab mus rau xyoo 1998, thaum nws tau pom tias kev siv tshuaj pleev ib ce ntawm PEA tuaj yeem cuam tshuam qhov mob tshwm sim los ntawm kev txhaj tshuaj plantar ntawm formalin, acetic acid, kaolin, lossis magnesium sulfate hauv nas. (Calignano li al., 1998, 2001), thiab hyperalgesia tom qab turpentine-induced zais zais zis hauv nas (Jaggar et al., 1998). Analgesia uas tsim los ntawm PEA yog xav tias yuav kho los ntawm peripheral CB2 receptors vim tias nws tau thim rov qab los ntawm CB2 receptor antagonist SR144528 (Calignano li al., 1998-2001; Farquhar-Smith thiab Rice, 2001).

Tom qab ntawd, PPAR-agonists raug suav hais tias yog ib chav kawm tshiab ntawm cov tshuaj tua kab mob, raws li GW7647 tau pom tias muaj txiaj ntsig zoo li PEA hauv kev txo tus cwj pwm mob hauv cov nas vim yog txhaj tshuaj formalin lossis magnesium sulfate, nrog rau cov mob neuropathic Hyperalgesic cov lus teb hauv cov kab mob ntev ntev. raug mob (CCI) qauv ntawm qhov mob inflammatory los yog ua tiav Freund's adjuvant thiab carrageenan qauv ntawm inflammatory mob (Lo-Verme li al., 2006; D'Agostino li al., 2009; Di-Cesare Mannelli li al. , 2013).

Cov khoom siv tshuaj kho mob ntawm micronized thiab ultramicronized formulations ntawm PEA (piv txwv li, m-PEA thiab um-PEA) tau pib pom hauv carrageenan-induced nas qauv ntawm inflammatory mob nyob rau hauv uas carrageenan induced paw edema thiab thermal hyperalgesia los ntawm qhov ncauj kev tswj ntawm ob formulations qhia. txo qhov tseem ceeb (Impellizzeri li al., 2014). Tom qab ntawd, cov kev tshawb fawb soj ntsuam tau pom qhov ua tau zoo ntawm m-PEA thiab um-PEA, yog siv ib leeg lossis ua ke nrog cov tshuaj tua kab mob antioxidant stilbene, polydatin. Tshwj xeeb, nws tau pom tias kev tswj hwm ntawm m-PEA (300 mg po ob zaug ib hnub) txo qhov mob ntawm cov neeg mob ntshav qab zib nrog peripheral neuropathy (Schifilliti li al., 2014). Qhov tseem ceeb, hematology thiab urinalysis tau qhia tias tsis muaj kev hloov pauv ntawm m-PEA, thiab tsis muaj qhov tshwm sim tsis zoo (Schifilliti li al., 2014). Muab ua ke, cov kev tshawb pom no qhia tias PEA, ib leeg lossis ua ke nrog polydatin, yog ib qho kev cog lus tshiab thiab kev zam zoo rau kev kho mob ntev ntawm cov kab mob sib txawv.

Kab mob o

Cov tshuaj tiv thaiv kab mob ntawm PEA zoo li feem ntau cuam tshuam nrog nws lub peev xwm los tswj cov kab mob mast cell activation thiab degranulation, ib qho txiaj ntsig tseem hu ua ALIA (Autologous Local Inflammation Antagonism) mechanism (Aloe li al., 1993; Facci li al., 1995). Thawj cov pov thawj ntawm cov tshuaj tiv thaiv kab mob ntawm PEA hauv cov qauv tsiaj tau tshaj tawm los ntawm Mazzari li al. (1996), uas qhia tau hais tias qhov ncauj tswj hwm ntawm PEA muaj peev xwm txo tau tus naj npawb ntawm degranulated mast hlwb thiab ntshav plasma extravasation induced los ntawm P txhaj tshuaj nyob rau hauv pinna ntawm nas (Mazzari li al. et al., 1996).

Kev tswj hwm qhov ncauj ntawm PEA kuj txo qis paw edema tshwm sim los ntawm carrageenan, dextran, thiab formalin, qhia tias cov compound ncaj qha downregulates mast cell activation nyob rau hauv vivo thiab inhibits pathological tshwm sim ntawm mast cell activation tsis hais txog kev ua kom stimulus (Mazzari li al. , xyoo 1996. ).

Cov tshuaj tiv thaiv kab mob ntawm PEA kuj tau kawm hauv ntau yam kab mob. Hauv particular, qhov ua tau zoo ntawm cov lipid compound no tau pom nyob rau hauv ntau tus tsiaj qauv ntawm cov kab mob plab hnyuv, xws li croton oil-induced chronic intestinalitis, dextran sodium sulfate (DSS)-induced ulcerative colitis, mustard oil (OM)-induced accelerated transport. thiab dinitrobenzenesulfonic acid (DNBS)-induced colitis

Formulation of PEA

PEA muaj nyob rau hauv cov ntsiav tshuaj, hmoov, capsules, thiab lwm yam.

PEA yog cov khoom tsis zoo hauv cov dej-soluble, yog li tus nqi ntawm kev sib cais feem ntau yog tus nqi txwv rau qhov ncauj nqus thiab bioavailability. Tus nqi ntawm dissolution yog cuam tshuam los ntawm tej yam xws li particle loj, yog li cov tshuaj feem ntau yog micronized rau sai dissolution.

Preclinical thiab tib neeg cov kev tshawb fawb tau pom tias PEA yog ib qho cuab yeej kho mob, tshwj xeeb tshaj yog thaum PEA yog micronized hauv micronized lossis ultra-micronized daim ntawv ua ke nrog cov tshuaj antioxidants xws li luteolin thiab polydatin, nws muaj peev xwm ua tau zoo rau kev kho mob sib txawv ntawm cov kab mob neurodegeneration, (neuro ) mob thiab mob

Nyob rau hauv luv luv, cov txheej txheem micronization tsim cov khoom me me uas ua rau thaj tsam ntau dua. Qhov no tso cai rau lub plab zom mov ib puag ncig kom ze rau qhov chaw dawb ntawm cov tshuaj, yog li kev tawg sai sai tuaj yeem ua tiav. Qhov no tuaj yeem ua rau kom zoo dua adsorption ntawm cov tshuaj molecules 46 . Hauv cov nas, nws tau raug tshaj tawm tias kev tswj hwm qhov ncauj ntawm micronized thiab ultramicronized PEA yog qhov ua tau zoo dua li cov tsis-micronized PEA hauv cov qauv carrageenan ntawm qhov mob. Txawm li cas los xij, hauv txoj kev tshawb no, kev tsim ntawm PEA tau yaj hauv carboxymethylcellulose ua ntej kev tswj hwm qhov ncauj lossis intraperitoneal, uas yog, nws twb tau yaj hauv cov tshuaj, uas yuav cia siab tias yuav dhau los ntawm cov txiaj ntsig ntawm micronization. Lub taub hau sib piv ntawm cov qauv sib txawv ntawm tib neeg PEA tsis muaj thiab yog li tsis muaj kev tshawb fawb soj ntsuam

Thaum ntxov siv keeb kwm thiab kev cai raws li txoj cai:

PEA tau txheeb xyuas nyob rau xyoo 1950 ua cov tshuaj kho mob uas muaj zog tiv thaiv kab mob. Txij li xyoo 1970, cov tshuaj tiv thaiv kab mob thiab lwm yam tshuaj tiv thaiv kab mob ntawm PEA tau pom nyob rau hauv ntau cov placebo-tswj, ob-dig muag kev sim tshuaj tiv thaiv kab mob khaub thuas thiab mob khaub thuas.

Xyoo 1975, Czech cov kws kho mob tau piav qhia txog cov txiaj ntsig ntawm kev sim tshuaj kho mob rau kev sib koom ua ke (qhov xav tau qhia meej) uas cov tshuaj aspirin tau sim tawm tsam PEA rau kev kho mob; ob qho tshuaj tau tshaj tawm los txhim kho kev sib koom tes thiab txo qhov mob. [14]

Xyoo 1970, Czechoslovakian cov chaw tsim tshuaj Spofa tau tshaj tawm cov koob tshuaj ntawm PEA pulsar rau kev kho mob thiab tiv thaiv kab mob khaub thuas thiab lwm yam kab mob ua pa.

Hauv Spain, lub tuam txhab Almirall tau tsim Palmidrol hauv cov ntsiav tshuaj thiab daim ntawv ncua kev kawm xyoo 1976 rau tib qhov kev qhia.

PEA yog tam sim no ua lag luam rau cov kws kho tsiaj siv (Daim tawv nqaij, Onyx ™, [Innovet]) thiab ua cov khoom noj rau tib neeg (Normal™, Pervelen™ [Epitech]), Pea Pure™ [JP Russel Science Ltd]) hauv qee lub tebchaws nyob sab Europe ( xws li Ltalis, Spain; ua lag luam raws li cov khoom noj ntxiv hauv lwm tus (xws li Netherlands).

Txij li xyoo 2008, PEA tau ua lag luam hauv Ltalis thiab Spain ua zaub mov rau kev kho mob tshwj xeeb raws li lub npe Normast (Epitech Srl). Tsis ntev los no, cov khoom noj ntxiv hu ua PeaPure (JP Russell Science Ltd.) tau pib.

Nws raug muag raws li cov khoom noj ntxiv hauv lwm lub tebchaws, xws li Netherlands. Nws kuj yog ib qho khoom muaj nyob rau hauv cream (Physiogel AI™, Stiefel) rau cov tawv nqaij qhuav.

Nyob rau hauv Teb Chaws Asmeskas, PEA raug soj ntsuam raws li ib tug nutraceutical rau kev kho mob ntawm plab hnyuv kab mob (pom zoo lub npe yog Recoclix, CM&D Pharma Ltd.; Nestle).

Xyoo 2020, US Food and Drug Administration (FDA) tau pom zoo ib qho kev sim tshuaj tsis tu ncua los ntawm FSD Pharma Inc siv Ultrafine Powder (UM)-PEA raws li kev kho mob rau tus mob ua pa nyuaj rau tus mob coronavirus 2 (SARS-CoV{-2) Ntxiv kho kab mob.

Daim ntawv thov

Palmitoylethanolamide(PEA) Cas544-31-0 tuaj yeem siv dav hauv cov khoom lag luam nruab nrab thiab tshuaj.

Specification

5.HPLC

6. HNMR

7. Kev Tshawb Fawb Txog Kev Nyab Xeeb thiab Kev Nyab Xeeb

Kono R & D pab neeg tau cog lus tas li rau kev tshawb fawb thiab kev tsim cov khoom xyaw tshiab, thaum ntxov 2021 tau ua tiav PEA hmoov, tam sim no muaj peev xwm tsim tau txhua hli ntawm 20 tons, txuas ntxiv.

Peb tsis tsuas yog cov kws tshaj lij hauv kev tshawb fawb, kev tsim kho thiab kev tsim khoom, tab sis kuj muaj kev lees paub zoo ntawm cov khoom xyaw zaub mov. Peb cov kev tshawb fawb suav nrog kev sim kuaj, kev tsim khoom, kev nyab xeeb thiab kev ua tau zoo hauv cov tsiaj thiab tib neeg.

Peb pab neeg ntawm cov neeg ua haujlwm mob siab rau pab cov neeg siv khoom thoob ntiaj teb siv cov khoom xyaw zoo tshaj plaws nrog cov thev naus laus zis tshiab. Effepharm tuaj yeem muab ntau yam kev qhia tshwj xeeb rau koj xaiv, suav nrog cov hmoov zoo tib yam palmitoylethanolamide (PEA), ultra-micronized PEA hmoov, thiab micronized PEA granules.

8. Daim Ntawv Qhia Txog Kev Xeem Thib Peb

Peb tau ua ntau yam kev ntsuam xyuas thib 3 rau cov khoom no hauv xyoo dhau los los ntawm cov koom haum xws li SGS, Eurofins, Pony ect. Ib qho ntawm koj qhov kev xeem yuav tsum tau ua tiav ntawm no.Pls email rau kuv yog tias koj xav tau cov ntsiab lus.

9. Cov ntawv pov thawj

Kono Chem Co.Ltd tau lees paub los ntawm ISO22000 los ntawm lub cev muaj ntawv pov thawj

10.Main Clients

Kono Chem Co.Ltd tau dhau los ua tus tswv cuab tseem ceeb hauv kev muab xxx rau lub ntiaj teb nto moo khoom noj, tshuaj thiab tshuaj pleev ib ce

11. Exhibitions

Peb ib txwm tuaj koom kev ncaj ncees xws li CPHi, FIC, Vitafoods, Supplyside sab hnub poob thiab nthuav peb lub lag luam nyob rau hauv cov ces kaum ntawm lub ntiaj teb no, thiab xav kom cov neeg nyob rau hauv lub ntiaj teb no tau txais txiaj ntsim los ntawm Kono Chem Co.Ltd.

12. Cov neeg siv khoom tawm tswv yim

Peb muaj Tebchaws USA warehouse hauv Miami thiab EU warehouse hauv ltalis, peb muaj cov khw muag khoom online hauv Alibaba, uas tuaj yeem lav qhov yooj yim ntawm kev hloov pauv, cov tswv yim no kuj tau txais tos los ntawm peb cov neeg siv khoom.

Cim npe nrov: Palmitoylethanolamide (PEA) Cas{0}}, manufacturers, lwm tus neeg, Hoobkas, lag luam wholesale, yuav, nqe, zoo tshaj plaws, tej, kev muag khoom