Tauroursodeoxycholic Acid Sodium 35807-85-3

1. Taw qhia

Lub npe tshuaj ntawm taurine ursodeoxycholic acid (TUDCA) yog 3 , xya Dihydroxycholanyl-N-ttaurine yog ib tug conjugated bile acid tsim los ntawm condensation ntawm cov amino pawg ntawm taurine thiab somyl pawg ntawm ursodeoxycholic acid (UDCA). TUDCA tau pom nyob rau hauv dais bile nyob rau hauv 1902. Nws yog lub ntsiab kua tsib acid nyob rau hauv dais bile, thiab muaj lub zog ntawm antispasmodic, anticonvulsant, anti-inflammatory thiab gallstone dissolving. Taurosodeoxycholic acid (1) yog ib qho tseem ceeb ntawm cov kua tsib, nrog rau cov tshuaj npe ntawm 2 - [(3, tsib, xya)- 3,7-dihydroxy-24-oxycholestane{ {11}}yl] amino] ethanesulfonic acid dihydrate, tsim los ntawm Italian Besidi Pharmaceutical Factory, yog thawj zaug nyob rau hauv ltalis xyoo 1991. Nyob rau hauv 2007, nws tau pom zoo kom muag nyob rau hauv Tuam Tshoj raws li kev lag luam npe taurolite. kev kho mob ntawm cov cholesterol gallstones, thawj sclerosing cholangitis, thawj biliary cirrhosis thiab chronic hepatitis C. Cov kev tshawb fawb soj ntsuam qhia tau hais tias: 1 Piv nrog ursodeoxycholic acid, qhov ceev ntawm pob zeb dissolution yog sai dua, tag nrho cov dissolution tus nqi yog siab dua, thiab tsis muaj qhov pom tseeb. kev phiv tshuaj.

2.Main Function

Taurus ursodeoxycholic acid yog hais txog taurus ursodeoxycholic acid capsules. Taurus ursodeoxycholic acid capsules tuaj yeem txhawb cov kua tsib lub zais zis, txhawb kev tso tawm ntawm lub gallstones, thiab tiv thaiv daim siab hlwb, tab sis lawv yuav tsum tau siv kom tsim nyog raws li kev qhia ntawm kws kho mob.

1. Txhawb cov kua tsib zais cia: taurine ursodeoxycholic acid capsule yog tsim los ntawm taurine ursodeoxycholic acid, uas tuaj yeem txhawb cov kua tsib tom qab nkag mus rau hauv lub cev. Yog tias muaj cov kua tsib tsis txaus, cov tshuaj tuaj yeem siv rau kev kho mob raws li tus kws kho mob cov lus qhia, uas feem ntau muaj cov txiaj ntsig zoo.

2. Txhawb lub excretion ntawm gallstones: taurine ursodeoxycholic acid capsule muaj cov nyhuv ntawm dissolving gallstones. Yog tias muaj cov pob zeb hauv lub gallstones thiab lwm yam kab mob, thiab lub ntim ntawm cov pob zeb yog me me, thiab tus neeg mob tsis kam mus rau kev kho mob phais, lub sijhawm no, cov tshuaj tuaj yeem siv raws li tus kws kho mob cov lus qhia rau kev kho mob, uas tuaj yeem ua tiav lub hom phiaj. kho tus kab mob mus rau ib qho twg.

3. Tiv thaiv daim siab hlwb: taurine ursodeoxycholic acid capsule tuaj yeem tiv thaiv daim siab rau qee yam, thiab txawm tias inhibit qhov tso tawm ntawm cov cholesterol. Yog tias cov roj cholesterol lom yog tshwm sim los ntawm gallstone, koj tuaj yeem siv cov tshuaj no rau kev kho mob raws li tus kws kho mob cov lus qhia.

Thaum lub sijhawm noj tshuaj, peb kuj yuav tsum tau ua tib zoo saib xyuas cov zaub mov noj qab haus huv thiab sim ua kom pom tseeb ntawm cov zaub mov, tab sis nws tsis pom zoo kom noj cov khoom noj uas muaj roj ntau, xws li nqaij rog, kib nqaij qaib, thiab lwm yam.

3. Daim ntawv thov

TUDCA tau txais daim ntawv pov thawj FDA tiag tiag thiab tuaj yeem siv los kho cov kab mob siab xws li cholestasis, uas yog ib yam kab mob uas tsim los yog tawm ntawm cov kua tsib los ntawm lub siab qeeb lossis nres. Ntxiv TUDCA tuaj yeem pab lub cev rov zoo thiab ua kom cov kua tsib tso tawm.

Qhov txiaj ntsig tseem ceeb ntawm TUDCA yog txhawm rau txhim kho daim siab mob thiab ua haujlwm. Txoj kev tshawb no hais txog cov txiaj ntsig zoo ntawm daim siab enzyme txo qis tom qab TUDCA ntxiv. Lub siab siab enzymes qhia tias daim siab noj qab nyob zoo thiab ua haujlwm, thaum lub siab tsis tshua muaj enzymes qhia tias daim siab noj qab nyob zoo thiab ua haujlwm. TUDCA supplementation pom qhov txo qis hauv daim siab tseem ceeb enzymes, sawv cev rau kev txhim kho daim siab mob.

Cov kev txhim kho hauv daim siab mob ua rau TUDCA muaj kev cuam tshuam rau cov neeg siv cov tshuaj anabolic, tshwj xeeb tshaj yog cov tshuaj anabolic hauv qhov ncauj. Cov tshuaj no yuav muaj txiaj ntsig zoo rau kev noj qab haus huv thiab kev ua haujlwm ntawm peb lub siab. Ntxiv nrog rau kev kuaj ntshav tsis tu ncua los saib xyuas kev noj qab haus huv, nws yog ib txwm pom zoo kom noj cov tshuaj txhawb nqa raws sijhawm. TUDCA yog suav tias yog ib qho ntawm cov khoom siv siab zoo tshaj plaws niaj hnub no.

Cov txiaj ntsig tsis yog daim siab xwb, tab sis kuj yog cov txiaj ntsig ntxiv ntawm TUDCA. Peb xav tau kev paub txog kev tshawb fawb me ntsis ntxiv kom nkag siab zoo dua cov khoom xyaw no

Apoptosis yog cell tuag uas tshwm sim raws li ib feem ntawm kev loj hlob thiab kev loj hlob ntawm cov kab mob. Ib feem tseem ceeb ntawm cov hlwb koom nrog hauv apoptosis yog mitochondria. Mitochondria yog lub zog ntawm peb cov hlwb, lub luag haujlwm muab lub zog rau cov hlwb. Mitochondria kuj tso tawm thiab qhib qee cov molecules uas ua lub luag haujlwm hauv kev pib cell apoptosis. Thaum ib yam dab tsi cuam tshuam rau mitochondrial membrane, mitochondria yuav tso tawm ib qho molecule hu ua cytochrome c. Tom qab ntawd cytochrome c invokes ib qho enzyme hu ua caspase, thiab tom qab ntawd pib cov tshuaj tiv thaiv cascade ua rau apoptosis.

TUDCA tuaj yeem tiv thaiv mitochondria los ntawm kev cuam tshuam ntawm cov khoom ntawm tes uas feem ntau ua rau muaj kev cuam tshuam, yog li tiv thaiv cell apoptosis. Nws ua qhov no los ntawm kev tiv thaiv ib qho molecule hu ua Bax los ntawm kev thauj mus rau mitochondria. Thaum Bax hloov los ntawm cytosol mus rau mitochondria, nws yuav rhuav tshem cov mitochondrial membrane, yog li ua rau muaj kev cuam tshuam ntau. Los ntawm kev thaiv Bax los ntawm TUDCA, nws yuav thaiv cov synthesis ntawm cell membrane, thiab tom qab ntawd thaiv kev tso tawm ntawm cytochrome c, yog li tiv thaiv kev ua kom cov caspase los ntawm mitochondria. TUDCA tiv thaiv kev tuag ntawm tes los ntawm kev tiv thaiv mitochondrial membrane ntawm cov hlwb.

TUDCA tiv thaiv kev tuag ntawm tes los ntawm kev tiv thaiv cell mitochondrial membrane los ntawm cov khoom tsis zoo. Cov txheej txheem no thiab lub cev cov tshuaj tiv thaiv yog vim li cas txoj kev tshawb fawb tau kawm txog cov txiaj ntsig ntawm TUDCA supplementation rau cov neeg muaj kab mob hauv lub paj hlwb (xws li Parkinson's disease, Huntington's disease, Alzheimer's disease thiab ALS). Cov txiaj ntsig ntawm cov kev tshawb fawb no thiab cov lus pom zoo thaum ntxov yog qhov zoo siab heev. TUDCA tuaj yeem muaj qee qhov txiaj ntsig zoo rau qee yam kab mob loj.

Txoj kev tshawb no tseem qhia tau hais tias cov tshuaj insulin rhiab heev ntawm cov leeg thiab daim siab tau txhim kho thiab muaj kev cuam tshuam zoo rau cov thyroid noj qab haus huv. Ib txoj kev tshawb fawb siv cov tsiaj thiab cov koob tshuaj loj heev ntawm TUDCA tau pom tias kev tiv thaiv neuroprotection tuaj yeem txhim kho lub hnub nyoog ntsig txog kev nco. Cov kev tshawb fawb no tsis tuaj yeem piav qhia tias TUDCA ua li cas qhov no. Cov kev tshawb fawb tib neeg xav tau ntau ntxiv kom tau txais cov txiaj ntsig thiab cov koob tshuaj ntau dua.

4.Quality Standard

5.Txoj kev tsom xam

1 Chromatographic tej yam kev mob

Chromatographic kem: Welchrom C18 (250mmx4.6mm, 5 μ m) Kem yog tsom kab, acetonitrile: tsis

Kev daws (siv 3.4g ntawm potassium dihydrogen phosphate, 0.506g ntawm sodium heptane sulfonate, ntxiv dej rau 500ml, sib tov zoo) =37: 63 (V / V)

Yog mobile theem; Qhov ntsuas wavelength yog 210 nm.

2.2 Xaiv cov xwm txheej chromatographic

2.2.1 Xaiv qhov kev tshawb pom wavelength thiab theem mobile

Los ntawm kev txiav txim siab UV ntawm taurine ursodeoxycholic acid aqueous tov, nws pom tias nws tsuas muaj qhov nqus nqus thiab ntsuas lub suab nrov.

Qib siab thiab qis rhiab heev. Txhawm rau kom paub tseeb tias qhov kev xav tau thiab tsis txhob muaj suab nrov cuam tshuam, 210nm raug xaiv

Yog qhov kuaj pom wavelength. Acetonitrile: buffer tov (siv 3.4g ntawm poov tshuaj dihydrogen phosphate, 0.506g ntawm sodium heptanesulfonate, thiab ntxiv dej

Rau 500ml, sib tov zoo)=37: 63 (V / V) yog lub sijhawm txawb, lub sijhawm ncov yog qhov tsim nyog, thiab lub ncov zoo li qub. (Daim duab 1)

Ib Sodium taurine ursodeoxycholic acid (Central Inspection Institute)

B Taurine ursodeoxycholic acid (Nyiv)

C Ua haujlwm siv cov khoom siv taurine ursodeoxycholic acid

D Taurine goose deoxycholic acid (Central Inspection Institute)

Daim duab 1 Chromatogram ntawm cov qauv

2.2.2 Kev tshawb nrhiav tshwj xeeb

Noj 100mg ntawm cov khoom no thiab muab tso rau hauv 10ml ntim ntim, ntxiv cov theem txawb kom dilute nws mus rau qhov teev, thiab siv nws los ua cov tshuaj cia.

3 Kev txiav txim siab txog cov ntsiab lus

Ua kom hnyav qhov tsim nyog ntawm taurine ursodeoxycholic acid, ntxiv cov theem ntawm lub xov tooj ntawm tes kom yaj nws thiab ua rau hauv cov tshuaj uas muaj 0.25mg ib 1ml.

Raws li qhov kev sim tshuaj, npaj cov kev siv tshuaj nyob rau hauv tib txoj kev; Ntsuas cov kev tswj kev daws teeb meem thiab cov tshuaj ntsuam xyuas raws

nees nkaum μ L Txhaj rau hauv cov kua chromatograph thiab sau cov chromatogram mus rau 2 npaug ntawm lub sijhawm tuav ntawm lub ntsiab tivthaiv ncov. Ntsuas lub ncov saum npoo ntawm lub hauv paus ntsiab lus

Xam cov ntsiab lus los ntawm cov txheej txheem sab nraud. Cov txiaj ntsig tau pom nyob rau hauv Table 1.

2.4 Taurine goose deoxycholic acid

Tauronodeoxycholic acid yog lub isomer ntawm tauronodeoxycholic acid. Vim nws cov qauv zoo sib xws, feem ntau TLC

Txoj kev tsis tuaj yeem sib cais thiab kuaj xyuas lawv zoo, thiab HPLC txoj kev tuaj yeem siv los tshem tawm taurine geese

Kev soj ntsuam thiab kuaj pom ntawm oxycholic acid.

Ntxiv nrog rau cov qauv concentration ntawm 1mg / ml thiab qhov kev siv concentration ntawm 0.01mg / ml, raws li cov ntsiab lus txiav txim siab txoj kev

Siv 20ul ntawm kev tswj cov tshuaj thiab cov tshuaj ntsuam xyuas, txhaj rau hauv cov kua chromatograph, sau cov chromatogram, thiab yaj cov tshuaj ntsuam xyuas

Yog hais tias cov tshuaj qhia taurine goose deoxycholic acid ncov, xam cov ntsiab lus los ntawm cov txheej txheem sab nraud.

6.IR: KBr disc

7. Kev ruaj ntseg thiab kev nyab xeeb

Kev ruaj ntseg:

Nyob ruaj khov nyob rau hauv cov xwm txheej zoo (chav kub). Cov Ntaub Ntawv Kev ruaj ntseg muaj nyob rau ntawm koj qhov kev thov.
Kev nyab xeeb:

Raws li GARS (Feem ntau Pom Zoo Raws Li Kev Nyab Xeeb) Daim Ntawv Ceeb Toom ntawm Teb Chaws Asmeskas, nws muaj kev nyab xeeb rau tib neeg noj.

8. Flow Chart

Taurine ursodeoxycholic acid yog ib qho tseem ceeb ntawm dais bile, uas muaj cov txiaj ntsig zoo rau cov kab mob gallstones thiab kab mob siab. Nyob rau hauv xyoo tas los no, kev tshawb fawb teb ntawm taurine ursodeoxycholic acid tau ua haujlwm heev, thiab nws cov tshuaj synthesis tau nyiam heev. Nyob rau hauv Suav teb, taurine ursodeoxycholic acid yog yeej tau los ntawm cov khoom siv extraction ntawm dais bile, uas tsis siab purity thiab tsis haum rau loj-scale ntau lawm. [2] Cov tshuaj synthesis ntawm taurine ursodeoxycholic acid yog qhia los ntawm peb cov tshuaj semi-synthesis txawv teb chaws:

① Urodeoxycholic acid (2) reacted nrog ethyl chloroformate los yog tervalyl chloride los tsim cov anhydride sib xyaw, reacted nrog taurine (5) nyob rau hauv alkaline tej yam kev mob, thiab ces purified los ntawm ion txauv kem los npaj 1, nrog ib tug tag nrho yield ntawm txog 62 feem pua ​​[2, 3]; [3]

② 2 thiab 5 tau ncaj qha condensed nyob rau hauv qhov kev txiav txim ntawm N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ, N-ethoxy-carbonyl-ethoxy-1, {{ 10}}dihydroquinoline) los yog diethyl cyanophosphate (DEPC, diethyl phosphate) nyob rau hauv alkaline tej yam kev mob kom tau txais 1, nrog yields ntawm 67 feem pua ​​thiab 90 feem pua, raws li; [4]

③ 2 thiab ethyl chloroformate daim ntawv sib xyaw anhydride, thiab tom qab ntawd condense nrog p-hydroxyphenylacetone kom tau 2 nquag phenol ester, thiab tom qab ntawd hnov ​​mob nrog taurine kom tau 1, nrog rau tag nrho cov txiaj ntsig ntawm kwv yees li 64 feem pua. Txoj kev no muaj ntau cov kauj ruam. Muab piv rau peb txoj kev sib txuas. Ob qhov tom kawg xav tau EEDQ thiab DEPC, uas yog kim thiab cumbersome. [5] Yog li ntawd, nws tsis zoo li yuav muaj cov tshuaj reagents zoo thiab txoj hauv kev los hloov cov kua tsib hauv lub sijhawm luv luv.

9. Cov neeg siv lus pom

Peb muaj cov khw muag khoom ntawm Alibaba, Chemicalbook thiab LookChem, los ntawm cov khoom lag luam zoo thiab cov kev pabcuam tsis tau txais kev pabcuam, peb tau txais ntau cov lus pom zoo.

10.Peb Cov Ntawv Pov Thawj

Tau ntau xyoo, peb tau cog lus rau cov khoom tsim khoom optimization thiab kev tsim kom zoo. Peb tau teeb tsa qhov kev tswj hwm zoo thiab tau txais daim ntawv pov thawj ntawm nws.

11.Peb cov neeg muas zaub

Peb tau tsim kev lag luam kev sib raug zoo nrog Abbott, Unilever, Shiseido, KANS thiab SIMM, thiab lwm yam.

12. Exhibitions

Peb feem ntau tuaj koom kev nthuav qhia thoob ntiaj teb, suav nrog CPhI, FIC, API, Vitafoods, SupplesideWest.

Cim npe nrov: Tauroursodeoxycholic acid sodium 35807-85-3, tuam ntxhab, lwm tus muag khoom, Hoobkas, lag luam wholesale, yuav, nqe, zoo tshaj plaws, tej, kev muag khoom