Nystatin 1400-61-9

Kono Chem Co., Ltd. yog ib qhov zoo tshaj plaws manufacturers thiab lwm tus neeg ntawm nystatin 1400-61-9 nyob rau hauv Suav teb. Peb sov siab txais tos koj rau cov lag luam wholesale bulk nystatin 1400-61-9 muag ntawm no los ntawm peb lub hoobkas. Tag nrho cov khoom siv tshuaj muaj txiaj ntsig zoo thiab cov nqi sib tw.

1. Taw qhia

Nystatin yog tshuaj tua kab mob polyene muab rho tawm los ntawm kab lis kev cai broth ntawmStreptomyces noursei. Nws feem ntau muaj peb yam khoom siv bioactive: Nystatin A1, A2, thiab A3. Tus cwj pwm los ntawm cov qauv sib txuas ntawm polyene macrolide, nws nthuav tawm cov haujlwm muaj zog tiv thaiv kab mob thaum tsis muaj kev cuam tshuam rau cov kab mob. Txij li thaum nws nrhiav tau nyob rau hauv 1950, Nystatin tau dav siv nyob rau hauv lub teb ntawm antifungal therapy.

Nystatin zoo nkaus li daj lossis daj - xim av hmoov nrog cov yam ntxwv tsw thiab hygroscopicity. Nws yog me ntsis soluble hauv dej, methanol, thiab ethanol, tab sis insoluble hauv acetone, ether, thiab chloroform. Qhov tseem ceeb, nws tsis ruaj khov nyob rau hauv raug huab cua, lub teeb, tshav kub, dej, acids, los yog alkalis, yuav tsum tau nruj me ntsis tswj ntawm ib puag ncig tej yam kev mob thaum lub sij hawm cia thiab siv.

2. Muaj nuj nqi

2.1. Antifungal Mechanism

Nystatin exerts nws antifungal nyhuv los ntawm tshwj xeeb khi rau sterols (xws li ergosterol) ntawm fungal cell membrane. Qhov kev khi no hloov pauv cov membrane permeability, ua rau cov dej ntws ntawm cov ntsiab lus tseem ceeb hauv lub cev, yog li inhibiting fungal kev ua haujlwm thiab ua tiav cov nyhuv fungistatic. Nyob rau hauv high concentrations, nws muaj peev xwm txawm exert ib tug fungicides. Nws cov txheej txheem ntawm kev ua haujlwm zoo ib yam li ntawm amphotericin B.

2.2. Antifungal Spectrum

Nystatin muaj ib tug dav antifungal spectrum. Nws qhia tau hais tias lub siab tshaj plaws antifungal kev tiv thaiv ntawm genusCandida. Tsis tas li ntawd, nws muaj txiaj ntsig tiv thaivCryptococcus neoformans, Aspergillus, Trichophyton, Coccidioides, Histoplasma capsulatum, Blastomyces dermatitisdermatophytes,Mucor, thiabMicrosporum.

3. Daim ntawv thov

3.1. Cov ntawv thov kho mob kho mob

(1) Kev kho cov kab mob mucocutaneous: Nws yog tsuas yog siv rau kev kho mob ntawmCandida albicanskab mob uas muaj nyob rau ntawm daim tawv nqaij, mucous daim nyias nyias, qhov ncauj kab noj hniav, txoj hnyuv, thiab qhov chaw mos. Cov ntaub ntawv ntau npaum li cas muaj xws li ntsiav tshuaj, tshuaj suppositories, tshuaj pleev, thiab kev ncua. Qhov kev kho mob siab tshaj plaws yog feem ntau ua tiav 24-72 teev tom qab siv tshuaj pleev ib ce. Nystatin tsis nqus los ntawm lub plab zom mov tom qab noj qhov ncauj, thiab nws tsis nqus los ntawm daim tawv nqaij lossis cov mucous membranes tom qab siv tshuaj pleev; yuav luag tag nrho cov koob tshuaj yog tawm hauv nws daim ntawv qub hauv cov quav.

(2) Kev tswj hwm ntawm lwm yam kab mob: Nws tuaj yeem siv los ua tus neeg sawv cev kho mob rau cov kab mob fungal sib sib zog nqus (xws liCryptococcus neoformansmob ntsws thiabMucorkab mob) nyob rau hauv cov neeg mob immunocompromised, nrog rau cov neeg muaj AIDS thiab cov tib neeg nyob rau lub sij hawm ntev - immunosuppressive therapy.

3.2. Cov ntawv thov tshawb fawb txog kev tshawb fawb

(1) Cell kab lis kev cai tiv thaiv: Ua hauj lwm raws li cov tshuaj tiv thaiv kab mob hauv cov kab lis kev cai ntawm tes los tiv thaiv cov kab mob fungal, tsis muaj kev pom zoo rau siab - siab lossis lim kom tsis muaj menyuam.

(2) Cytokine kev cai: Nrog muaj zog pro-cov khoom ua rau mob, nws ua rau TLR2 qhia hauv THP1 hlwb thiab txhawb nqa cytokine secretion, ua raws li cov cuab yeej tseem ceeb rau kev tshawb fawb tiv thaiv kab mob thiab mob.

(3) Kev tshawb fawb Biofilm: Ua haujlwm raws li ergosterol-binding pore- ua tus neeg sawv cev, tsim nystatin / ergosterol ion channels hauv lipid bilayers los txhawb cov qauv biofilm thiab kev kawm ua haujlwm.

4.Quality Standard

5.Txoj kev tsom xam

MOA muaj nyob rau thaum thov.

6. Kev ruaj ntseg thiab kev nyab xeeb

Kev ruaj ntseg:

kaw, qhuav thiab lub teeb- pov thawj cia ntawm chav tsev kub (15-30 degree) tswj kev ua tau zoo rau 2 xyoos; Tshuag tshuaj (50mg / ml ncua kev kawm ntawv) khaws cia ntawm -20℃yog ruaj khov rau kev siv mus ntev.

Kev nyab xeeb:

Tsawg mob toxicity; Kev tswj hwm qhov ncauj muaj qhov nqus tsis zoo ntawm plab hnyuv, yuav luag tsis muaj kev cuam tshuam rau lub cev.

7.Cov txheej txheem tsim khoom

(1) Kev ua kom muaj zog & Kev nthuav dav: Xaiv siab - tawm losStreptomyces nourseiCov kab mob, qhib rau ntawm cov khoom slants, thiab nthuav cov kab lis kev cai ntawm co flasks thiab noob tso tsheb hlau luam ntawm 28 degree, ua kom tsis muaj menyuam thiab muaj zog mycelia.

(2) Loj -Fermentation: Inoculate noob kua rau hauv fermenters, npaj nruab nrab nrog qabzib / soybean ncuav mog qab zib hmoov (carbon/nitrogen qhov chaw) thiab inorganic ntsev. Kab lis kev cai ntawm 26-28 degree, pH 6.0-7.0 rau 5-7 hnub nrog aeration thiab nplawm (solved oxygen: 20-40% saturation).

(3) Extraction & Purification: Lim fermentation broth kom tshem tawm impurities, extract nystatin nrog cov kuab tshuaj (xws li, methanol), purify los ntawm nag lossis daus thiab kem chromatography, ces khov - qhuav kom tau siab -purity API.

(4) Formulation & Quality Control: Process API rau hauv cov ntsiav tshuaj, suppositories, thiab lwm yam. Test potency (Ntau tshaj los yog sib npaug rau 4500 units/mg) thiab microbial txwv. foob ​​thiab ntim rau hauv lub teeb- cov thawv pov thawj tom qab dhau kev tshuaj xyuas.

8. Cov neeg siv lus pom

9.Peb Daim Ntawv Pov Thawj

10.Peb cov neeg muas zaub

11. Exhibitions

Cim npe nrov: Nystatin 1400-61-9, Tuam Tshoj nystatin 1400-61-9 manufacturers, lwm tus, Hoobkas