Lipoic Acid Hmoov USP Qib

1. Taw qhia

- Lipoic acid yog lub teeb daj hmoov siv lead ua, yuav luag tsis qab. Solubility hauv dej yog li 1 g / L (20 degree C). Nws yog soluble hauv 10 feem pua ​​NaOH kua thiab aliphatic hnyav. Nws yog soluble hauv methanol, ethanol, chloroform thiab ether.

Lipoic acid tseem hu ua lipoic acid - lipoic acid.

Lipoic Acid muaj chiral chaw, yog li nws muaj R thiab s configurations.

Ntuj lipoic acid yog siv lead ua dawb, tsuas yog R configuration, thiab tsuas yog R configuration ntawm lipoic acid yuav covalently conjugate rau lysine residue los ntawm amide daim ntawv cog lus los ua lub luag hauj lwm ntawm coenzyme.

Cov hluavtaws lipoic acid yog sib xyaw ntawm R-configuration thiab s-configuration nrog sib npaug sib npaug. Nws yog lub teeb daj hmoov thiab yooj yim soluble hauv lipid kuab tshuaj.

2.Main Function

Cov tshuaj vitamin rau cov kab mob siab thiab mob ntev, mob cirrhosis, mob siab coma, fatty siab, ntshav qab zib thiab lwm yam kab mob thiab kev kho mob kev kho mob.

Lipoic acid belongs rau chav kawm ntawm cov ntsiab lus ntawm cov vitamins B. Kev loj hlob ntawm cov poov xab thiab qee cov kab mob ua lub luag haujlwm coenzyme hauv ntau lub enzyme system, catalyzing oxidative decarboxylation ntawm pyruvate rau acetic acid thiab - Cov tshuaj tiv thaiv ntawm oxidative decarboxylation ntawm ketoglutaric acid rau succinic acid yog acyl conversion. Lub npe tshuaj yog 5 - [3 - (1,2-dithioheterocyclic)] valeric acid, cov tsos yog lub teeb daj siv lead ua, thiab qhov hnyav molecular yog 206.33. DL-lub cev: melting point 60 ~ 61 degree. L-lub cev (natural khoom): melting point 45 ~ 47.5 degree. Optical rotation [] D23 ntxiv rau 113 degree . D-lub cev (natural khoom): melting point 46 ~ 48 degree. Optical rotation [] D23 ntxiv rau 104 degree . Soluble nyob rau hauv cov organic solvents. Nws yog insoluble hauv dej. Nws yog siv los tiv thaiv thiab kho tus kab mob siab, mob siab cirrhosis, siab coma, fatty siab thiab lwm yam kab mob. Cov khoom ntuj tsim muaj nyob hauv daim siab, raum thiab lub plawv. Cov khoom hluavtaws yog npaj los ntawm condensation ntawm ethylene thiab adipic acid monoester acyl chloride nyob rau hauv lub xub ntiag ntawm txhuas trichloride kom tau chloropropionyl valeryl ester, condensation nrog sulfuric acid, txo nrog sodium borohydride thiab hydrolysis nrog caustic soda, thiab cov tshuaj tiv thaiv nrog thiourea, thiab lwm yam. , 8-dithiooctanoic acid. Soluble nyob rau hauv dej, feem ntau coexisting nrog vitamin B1. Muaj ob hom ntawv uas twb muaj lawm: hom oxidation thiab txo hom (6,8-dimethylcaproic acid). Hauv cov kab mob, qee pawg hydrogen lossis acyl tau txais lossis hloov los ntawm ob hom kev hloov pauv no. ua - Cov coenzyme ntawm keto acid oxidative decarboxylase thiab transhydroxyethylase ua lub luag haujlwm hauv kev thauj acyl thiab hydrogen hauv cov tshuaj tiv thaiv metabolic. Tib neeg lub cev tuaj yeem ua ke, yog li tsis muaj qhov tsis txaus. Tab sis nws yog ib qho tsim nyog rau kev loj hlob thiab kev loj hlob ntawm qee cov kab mob thiab protozoa. Nws yog nplua nuj nyob rau hauv daim siab thiab poov xab. Kev ua tau zoo thiab kev ua haujlwm lipoic acid tseem hu ua - Lipoic acid, tshwj xeeb tshaj yog nyob rau hauv cov xwm txheej, yog thawj zaug cais tawm ntawm daim siab npua los ntawm Reed hauv xyoo 1951. Lipoic acid yog ib qho disulfide compound ntawm ib hom vitamin, uas feem ntau suav tias yog vitamin B. . Lipoic acid yog ib qho tseem ceeb coenzyme nyob rau hauv cov kab mob, ib qho tseem ceeb cofactor ntawm pyruvate dehydrogenase, ketoglutarate dehydrogenase thiab aminocaproic acid dehydrogenase, thiab ib qho ntawm indispensable tshuaj nyob rau hauv lub tricarboxylic acid voj voog. Tib neeg lub cev tuaj yeem tsim cov lipoic acid txaus los ntawm nws tus kheej, thiab tsis muaj cov neeg mob uas muaj lipoic acid tsis txaus. Txawm li cas los xij, hauv txoj kev tshawb fawb, nws tau pom tias lipoic acid supplementation hauv vitro tuaj yeem cuam tshuam lipid oxidation ntawm cov ntaub so ntswg neural ntawm Chemicalbook, tiv thaiv glycosylation ntawm cov protein, inhibit aldose reductase, thiab tiv thaiv kev hloov pauv ntawm qabzib lossis galactose rau hauv sorbitol. Nws tau raug siv los ua cov tshuaj kho mob ntshav qab zib neuropathy lossis cov teeb meem hauv lub paj hlwb hauv Tebchaws Europe. Ntxiv nrog rau lub luag haujlwm ntawm coenzyme, lipoic acid kuj muaj cov tshuaj tiv thaiv kab mob antioxidant, uas tuaj yeem tshem tawm cov dawb radicals uas ua rau kom ceev kev laus thiab kab mob. Nws muaj ntau yam haujlwm xws li tiv thaiv oxidation, tiv thaiv kev laus, txhim kho kev tiv thaiv kab mob, tiv thaiv kab mob plawv, thiab txo cov tsos mob ntshav qab zib. Thaum lub sijhawm nce ntawm cov khoom noj antioxidant, lipoic acid yog hloov los ntawm cov tshuaj ib txwm mus rau zaub mov. Raws li nws txoj kev noj qab haus huv muaj zog, Nyiv lub xeev Houlao tau hloov nws cov kev faib tawm los ntawm cov tshuaj mus rau cov zaub mov thaum Lub Rau Hli 2004. Tsis tas li ntawd, lipoic acid tau teev npe raws li kev noj haus hauv Tebchaws Meskas, Canada thiab lwm thaj chaw. Cov tshuaj tiv thaiv antioxidant ntawm lipoic acid lipoic acid muaj zog antioxidant muaj peev xwm, nws lub peev xwm los tiv thaiv dawb radical yog 400 npaug zoo dua VC thiab VE, tuaj yeem tshem tawm cov khoom siv oxygen uas ua rau tawv nqaij laus, thiab me dua cov molecule ntawm VE. Tsis tas li ntawd, lipoic acid muaj ob qho tib si dej-soluble thiab fat-soluble zog, yog li daim tawv nqaij nqus tau yooj yim heev. Lipoic acid tsis yog tsuas yog muaj zog tiv thaiv oxidative kev puas tsuaj mus sij hawm ntev, tab sis kuj tuaj yeem kho cov cell oxidative puas loj dua uas VC thiab VE kho tsis tau. Cov kev tshawb fawb tau pom tias lipoic acid tuaj yeem hloov mus rau hauv dihydrolipoic acid hauv vivo, ob qho tib si muaj zog antioxidant zog thiab ua lub luag haujlwm sib luag hauv vivo.

3. Daim ntawv thov

1. Pab cov neeg mob txo lawv txoj kev cia siab rau cov tshuaj insulin thiab cov tshuaj hypoglycemic

- Lipoic acid yog tib lub universal oxygen activator nrog ob qho tib si roj soluble thiab dej soluble zog, thiab nws qhov kev ua tau ntev dua li lwm cov tshuaj antioxidants. Lipoic acid tuaj yeem sib npaug cov ntshav qab zib, txhawb kev nqus cov piam thaj, txhim kho glycemic tswj hauv cov neeg mob ntshav qab zib, thiab txo qis kev siv tshuaj insulin lossis tshuaj hypoglycemic.

2. Tiv thaiv cov paj hlwb ntawm cov neeg mob ntshav qab zib thiab pab kho peripheral neuropathy.

Cov kev tshawb fawb txawv teb chaws tau ua pov thawj tias Lipoic acid tuaj yeem txhim kho cov tsos mob tshwm sim los ntawm ntshav qab zib peripheral neuropathy. Nws tau raug pom zoo nyob rau hauv lub teb chaws Yelemees rau adjuvant kho mob ntshav qab zib peripheral neuropathy rau ntau tshaj 30 xyoo. Lipoic acid tuaj yeem tiv thaiv cov paj hlwb ntawm cov neeg mob ntshav qab zib thiab pab kho qhov mob tshwm sim los ntawm cov protein deposition hauv paj hlwb.

3, Lipoic acid yog lub zog antioxidant

Lub peev xwm antioxidant ntawm lipoic acid yog 5-10 npaug ntawm cov txiv hmab txiv ntoo, thiab lub peev xwm antioxidant ntawm cov txiv hmab txiv ntoo yog 20 npaug ntawm cov vitamin C. Vitamin E yog 60 npaug ntau npaum li cov vitamin E, uas yog rog soluble thiab dej. -soluble, thiab tuaj yeem nqus tau los ntawm ntau cov ntaub so ntswg thiab kabmob.

4.Quality Standard

5.Txoj kev tsom xam

QHIA

· txheej txheem

Buffer tov: 0.68 g/L ntawm monobasic potassium phosphateMobile theem: Methanol, Bufer tov, thiab acetonitrile (58:46.9). Kho nrog phosphoric acid tov (8.3 hauv 100) rau pH ntawm 3.0-

3.1.

Standard tov: 1.0 mg/mL ntawm USP Alpha Lipolc Acid RS nyob rau hauv Mobile phaseSample tov: 1.0 mg/mL ntawm Alpha Lipoic Acid nyob rau hauv Mobile phaseChromatographic system

(Saib Chromatography (621), System Surtability.) Hom: LC

Detector: UV 215 nm

Kem: 4.6-mm x 250-mm; ntim L1

Kem kub: 35

Tus nqi ntws: 1.2 mL / min

kev txhaj tshuaj loj: 20 ul

Qhov system haum

Qauv: Standard tov

Suitability xav tau

Kem efficiency: NLT 10, 000 theoretical phaj

Qhov siab tshaj plaws: NMT 2.0 rau alpha lipoic acid ncov

Kev txheeb ze tus qauv devlation: NMT 2.0 feem pua ​​​​rau alpha lipoic acidAnalysisSamples: Standard tov thiab Sample tov

Xam cov feem pua ​​​​ntawm alpha lipoic acid (C, H, 0}, S,) hauv feem ntawm Alpha Lipoic Acid noj:

Cov txiaj ntsig=(r,/rg)x (C/C)x 100

= cov lus teb siab tshaj plaws los ntawm Cov Qauv Qauv

= cov lus teb siab tshaj plaws los ntawm kev daws teeb meem

= concentration ntawm USP Alpha Lipoic Acid RS nyob rau hauv Standard tov (mg/mL)

c.= concentration ntawm Alpha Lipoic Acid nyob rau hauv cov qauv tov (mg/mL)

Kev lees txais cov qauv: 99.0 feem pua ​​-101.0 feem pua ​​ntawm cov hauv paus qhuav

6.IR: KBr disc

7. Kev ruaj ntseg thiab kev nyab xeeb

Kev ruaj ntseg:

Nyob ruaj khov nyob rau hauv cov xwm txheej zoo (chav kub). Cov Ntaub Ntawv Kev ruaj ntseg muaj nyob rau ntawm koj qhov kev thov.
Kev nyab xeeb:

Raws li GARS (Feem ntau Pom Zoo Raws Li Kev Nyab Xeeb) Daim Ntawv Ceeb Toom ntawm Teb Chaws Asmeskas, nws muaj kev nyab xeeb rau tib neeg noj.

8. Flow Chart

9. Cov neeg siv lus pom

Peb muaj cov khw muag khoom ntawm Alibaba, Chemicalbook thiab LookChem, los ntawm cov khoom lag luam zoo thiab cov kev pabcuam tsis tau txais kev pabcuam, peb tau txais ntau cov lus pom zoo.

10.Peb Cov Ntawv Pov Thawj

Tau ntau xyoo, peb tau cog lus rau cov khoom tsim khoom optimization thiab kev tsim kom zoo. Peb tau teeb tsa qhov kev tswj hwm zoo thiab tau txais daim ntawv pov thawj ntawm nws.

11.Peb cov neeg muas zaub

Peb tau tsim kev lag luam kev sib raug zoo nrog Abbott, Unilever, Shiseido, KANS thiab SIMM, thiab lwm yam.

12. Exhibitions

Peb feem ntau tuaj koom kev nthuav qhia thoob ntiaj teb, suav nrog CPhI, FIC, API, Vitafoods, SupplesideWest.

Cim npe nrov: lipoic acid hmoov usp qib, manufacturers, lwm tus neeg, Hoobkas, lag luam wholesale, yuav, nqe, zoo, tej, kev muag khoom