Kono Chem Co., Ltd. yog ib qho zoo tshaj plaws manufacturers thiab lwm tus neeg ntawm glutathione oxidized 121-24-4 hauv Suav teb. Peb sov siab txais tos koj rau cov lag luam wholesale bulk glutathione oxidized 121-24-4 muag ntawm no los ntawm peb lub hoobkas. Tag nrho cov khoom siv tshuaj muaj txiaj ntsig zoo thiab cov nqi sib tw.
1. Taw qhia
Oxidized glutathione, tseem hu ua GSSG, yog oxidized dimer daim ntawv ntawm glutathione (GSH), tsim los ntawm disulfide daim ntawv cog lus txuas ob GSH molecules. Nws zoo nkaus li dawb rau tawm- cov hmoov dawb nrog cov purity zoo tshaj los yog sib npaug li 99%, soluble hauv dej thiab ruaj khov thaum khaws cia hauv qhov txias, qhuav, thiab lub teeb - tiv thaiv tej yam kev mob. Dav siv thoob plaws cov chaw muag tshuaj, tshuaj pleev ib ce, thiab kev tshawb fawb biochemical, nws ua raws li cov tshuaj lom neeg txo qis hauv cov tshuaj formulations, antioxidant hauv cov khoom tu tawv nqaij, thiab cov reagent tseem ceeb rau kev kawm redox tshuav nyiaj li cas hauv cov kab mob lom.
2. Muaj nuj nqi
2.1Tswj intracellular redox homeostasis los ntawm kev sib npaug ntawm GSSG / GSH piv, tus cim tseem ceeb ntawm cellular redox xwm txheej.
2.2Txais cov electrons los ntawm txo glutathione (GSH) kom txo oxidative kev nyuaj siab thiab tiv thaiv hlwb los ntawm reactive oxygen hom (ROS)-induced puas.
2.3Koom tes nrog cov enzymes antioxidant (piv txwv li, glutathione peroxidase) kom tsis txhob muaj xenobiotics thiab cov metabolites tsis zoo, txhawb cov txheej txheem cellular detoxification.
2.4Tuav cov txheej txheem thiab kev ua haujlwm zoo ntawm cov protein los ntawm kev tswj cov khoom siv disulfide hauv cov kab ke lom neeg.
Koom tes hauv redox signaling pathways, cuam tshuam cov txheej txheem physiological xws li cell proliferation, sib txawv, thiab apoptosis.
3. Daim ntawv thov
Kev lag luam kws tshuaj: Siv los ua cov tshuaj tua kab mob hauv cov tshuaj tsim tshuaj los kho oxidative stress-cov kab mob ntsig txog (xws li, kab mob siab, kab mob neurodegenerative) thiab txo oxidative kev mob tshwm sim ntawm kev siv hluav taws xob thiab tshuaj khomob.
Kev lag luam tshuaj pleev ib ce: Ntxiv rau cov khoom tu tawv nqaij raws li lub zog antioxidant kom tshem tawm cov dawb radicals, ncua kev laus ntawm daim tawv nqaij, ua kom tawv nqaij tawv, thiab tiv thaiv daim tawv nqaij los ntawm UV hluav taws xob thiab ib puag ncig cov pa phem.
Kev tshawb fawb biochemical: Ua hauj lwm raws li ib tug tseem ceeb reagent rau kev kawm cellular redox metabolism, antioxidant tiv thaiv mechanisms, thiab lub pathogenesis ntawm ROS - kab mob (xws li, mob cancer, o).
Kev lag luam zaub mov: Siv los ua cov tshuaj tiv thaiv ntuj thiab antioxidant hauv cov khoom noj kom ntev lub neej txee los ntawm inhibiting lipid oxidation thiab tswj kev noj zaub mov zoo.
Veterinary tshuaj: Siv rau hauv cov khoom noj khoom haus tsiaj kom txo tau oxidative kev nyuaj siab hauv cov tsiaj nyeg thiab tsiaj txhu, txhim khu kev tiv thaiv kab mob, thiab txhawb lub siab thiab lub raum kev noj qab haus huv.
4. Tus Qauv Zoo
| Cov khoom | Specifications |
|---|---|
| Qhov tshwm sim | Dawb rau tawm -dawb crystalline hmoov |
| Assay | Ntau dua lossis sib npaug li 99.0% |
| Residue ntawm Ignition | Tsawg dua lossis sib npaug li 0.1% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 5.0% |
| Heavy Hlau (raws li Pb) | Tsawg dua lossis sib npaug li 10 ppm |
| Solubility (hauv dej, 25 degree) | Soluble |
| pH (1% Aqueous tov, 25 degree) | 4.0 - 6.0 |
| Yam khoom (HPLC) | Txhua impurity Tsawg dua lossis sib npaug li 0.5%, tag nrho impurities Tsawg dua lossis sib npaug rau 1.0% |
5. Txoj kev tsom xam
Siab -Kev Ua Haujlwm Liquid Chromatography (HPLC)Feem ntau yog siv rau kev txheeb xyuas qhov ntau. Rov qab-theem HPLC (C18 kem) nrog UV kuaj pom (210–220 nm) lossis kuaj pom fluorescence (tom qab derivatization nrog reagents zoo li o-phthaldehyde) yog tus qauv. Cov theem txawb (piv txwv li, acetonitrile- dej nrog trifluoroacetic acid, methanol-phosphate buffer) pab kom sib cais ntawm GSSG los ntawm GSH thiab lwm yam impurities. Sab nrauv lossis sab hauv tus qauv (xws li, siv cov qauv GSSG) ua kom muaj qhov tseeb, haum rau cov kua roj ntsha (plasma, zis) thiab kev kuaj tshuaj purity.
Liquid Chromatography-Mass Spectrometry (LC-MS/MS)Txaus siab rau kev txheeb xyuas kab thiab cov matrices nyuaj. LC cais cov analytes, thaum MS / MS muab siab xaiv thiab rhiab heev ntawm cov yam ntxwv ion hloov pauv (piv txwv li, m / z 613 → 307 rau GSSG). Minimizes matrix cuam tshuam, zoo tagnrho rau ntsuas GSSG qib qis hauv cov hlwb, cov ntaub so ntswg, lossis cov qauv zaub mov. Derivatization feem ntau tsis tsim nyog, simplifying tus qauv npaj.
Capillary Electrophoresis (CE)Ua haujlwm zoo rau cov ntsuas ntsuas. Siv cov tshuab tsis zoo (xws li, phosphate buffer, borate buffer) nrog UV lossis laser -induced fluorescence (LIF) nrhiav kom tau. Muab kev sib cais ceev ceev, tsawg tus qauv noj, thiab kev daws teeb meem siab rau GSSG / GSH sib txawv. Tsim nyog rau cov qauv siv roj ntsha (piv txwv li, cell lysates) thiab kev tshawb fawb biochemical.
SpectrophotometricRapid qualitative/quantitative method. Raws li cov tshuaj tiv thaiv xim: GSSG reacts nrog Ellman's reagent (5,5'-dithiobis-2-nitrobenzoic acid, DTNB) los tsim cov khoom daj (2-nitro-5-thiobenzoic acid, TNB) nrog kev nqus ntawm 412 nm. Kev ua haujlwm yooj yim tab sis qis dua xaiv; haum rau high-purity kuaj los yog kuaj ua ntej (piv txwv li, bulk tshuaj ntsuam xyuas).
Enzymatic AssayTshwj xeeb heev rau cov qauv siv roj ntsha. Siv glutathione reductase (GR) los ua kom txo qis ntawm GSSG rau GSH, nrog NADPH ua cofactor. Qhov txo qis hauv NADPH nqus ntawm 340 nm cuam tshuam nrog GSSG concentration. Tsis txhob cuam tshuam los ntawm lwm cov thiols, zoo tagnrho rau kev ntsuas intracellular GSSG qib hauv chaw kho mob lossis kev tshawb fawb.
6.Reference Chromatogram ntawm Glutathione OxidizedSubstance
7. Flow Chart
Cov ntaub ntawv pib → Fermentation → Harvesting thiab Cell Disruption → Crude Extraction → Oxidation → Primary Purification → Chromatographic Purification → Crystallization → Lyophilization → Quality Control → Final GSSG Product
8. Kev ruaj ntseg thiab kev nyab xeeb
Kev ruaj ntseg:
Nyob ruaj khov nyob rau hauv cov xwm txheej zoo (chav kub). Cov Ntaub Ntawv Kev ruaj ntseg muaj nyob rau ntawm koj qhov kev thov.
Kev nyab xeeb:
Raws li kev tshawb fawb, nws muaj kev nyab xeeb rau kev noj.
9. Cov neeg siv lus pom
Peb muaj cov khw muag khoom ntawm Alibaba, Chemicalbook thiab LookChem, los ntawm cov khoom lag luam zoo thiab cov kev pabcuam tsis tau txais kev pabcuam, peb tau txais ntau cov lus pom zoo.
10.Peb Daim Ntawv Pov Thawj
Tau ntau xyoo, peb tau cog lus rau cov khoom tsim khoom optimization thiab kev tsim kom zoo. Peb tau teeb tsa qhov kev tswj hwm zoo thiab tau txais daim ntawv pov thawj ntawm nws.
11.Peb cov neeg muas zaub
Peb tau tsim kev lag luam kev sib raug zoo nrog Abbott, Unilever, Shiseido, KANS thiab SIMM, thiab lwm yam.
12. Exhibitions
Peb feem ntau tuaj koom kev nthuav qhia thoob ntiaj teb, suav nrog CPhI, FIC, API, Vitafoods, SupplesideWest.
Cim npe nrov: Tuam Tshoj glutathione oxidized 121-24-4 manufacturers, lwm tus neeg, Hoobkas
