Citicoline hmoov 987-78-0

1 Kev Taw Qhia

Citicoline Powder yog ib qho endogenous nucleoside ib txwm ua nyob rau hauv lub cev thiab yog ib qho nruab nrab hauv txoj hauv kev tseem ceeb ntawm phospholipid biosynthesis hauv cell membranes. Kev kho cov paj hlwb ntawm cov paj hlwb yuav tsum muaj ntau ntawm citicoline. Supplementing exogenous citicoline tuaj yeem txhawb kev sib txuas ntawm phospholipids hauv paj hlwb. Citicoline Powder ua lub luag haujlwm tseem ceeb hauv kev tswj hwm ntau yam txheej txheem ntawm lub cev ntawm tes. Citicoline Powder muaj cov txiaj ntsig zoo hauv kev kho mob hauv ntau yam ntawm cov cell membrane tsis ua haujlwm thiab cov kab mob degenerative tshwm sim los ntawm ischemia thiab hemorrhage.

2 Muaj nuj nqi

Exogenous citicoline tuaj yeem decomposed rau hauv cytidine thiab choline los ntawm hydrolysis. Lub decomposed Citicoline Powder thiab cytidine tuaj yeem phosphorylated dua, thiab catalyzed los ntawm cytidine triphosphate-phosphocholine cytidine transferase, cytidine triphosphate thiab choline monophosphate tuaj yeem ua rau citicoline. Citicoline Powder thiab diacylglycerol synthesize phosphatidylcholine, uas ua rau lub bilayer lipid qauv ntawm cov cell membrane.

Cov choline decomposed los ntawm Citicoline Powder yog acetylated los tsim cov neurotransmitter acetylcholine. Lwm cov khoom ntawm choline decomposed, trimethylammonium acetolactone, generates S-adenosyl-L-methionine los ntawm methionine txoj kev, thiab thaum kawg ntxiv synthesizes glutathione nrog antioxidant nyhuv. Kev sim hauv vitro tau lees paub tias tsis txaus choline degrades phosphatidylcholine thiab sphingomyelin hauv paj hlwb, yog li ua rau apoptosis. Vim yog qhov txuas ntxiv ntxiv ntawm choline hauv catabolism ntawm exogenous citicoline, nws tuaj yeem tiv thaiv cov hlab ntsha cell membrane puas thiab cholinergic paj tuag.

3 Daim ntawv thov

3.1. Citicoline Powder tuaj yeem kho cov qauv ntawm cov cell membrane tom qab lub hlwb raug mob, txhim khu kev ua haujlwm ntawm cov cell membrane, thiab txhim kho cov haujlwm ntawm cov neurons;

3.2. Citicoline Powder tuaj yeem txo cov hlab plawv tsis ua haujlwm, ua kom cov ntshav ntws hauv hlwb, txhawb cov hlwb metabolism, txhim kho cerebral ncig, thiab txhim kho lub hlwb ua haujlwm; 3. Nws tuaj yeem ua rau kom muaj kev tso tawm ntawm cov neurotransmitters xws li acetylcholine thiab dopamine, thiab txhim kho lub hlwb kev sib txuas nrog rau kev nco qab. Nws tuaj yeem txhim kho lub xeev ntawm kev nco qab ntawm lub cev thiab ua kom nrawm nrawm;

3.4. Citicoline Powder tseem tuaj yeem cuam tshuam kev ua haujlwm ntawm phospholipase A2, yog li ua kom lub cev rov ua haujlwm ntawm cerebral ede.

3.5. Citicoline Powdercan txhim kho dopaminergic kev ua si thiab tswj lub cev muaj nuj nqi ntawm extrapyramidal system.

3.6. Citicoline Powder tau pom tias ua kom nco thiab txhawb kev kawm.

4 Tus Qauv Zoo

5 Txoj kev kuaj xyuas

Mobile theem: 10 mM tetrabutylammonium hydroxide thiab 15 mM dibasic sodium phosphate anhydrous, kho nrog 20 feem pua ​​​​phosphoric acid rau pH ntawm 6.0 .

Kev daws teeb meem: 25 µg / mL ntawm USP Citicoline RS hauv dej.

Piv txwv li: 25 µg / mL ntawm Citicoline hauv dej.

Chromatographic system.

Qauv: LC

Detector: UV 254 nm.

Kem: 4.6-mm × 25-cm; 5-µm ntim L96.

Kem kub: 40 degree.

Tus nqi ntws: 1.0 mL/min.

Txhaj ntim: 15 µL.

Qhov system haum.

Qauv: Standard tov.

Suitability xav tau.

Kem efficiency: NLT 2000 theoretical daim hlau rau citicoline.

Tus nqi qis: NMT 2.0 rau citicoline.

Tus qauv sib txawv: NMT 2.0 feem pua ​​rau citicoline.

Kev tsom xam

Cov qauv: Cov qauv kev daws teeb meem thiab cov qauv kev daws teeb meem.

Xam cov feem pua ​​​​ntawm citicoline (C14H26N4O11P2) hauv feem ntawm Citicoline noj:

Cov txiaj ntsig=(rU/rS) × (CS/CU) × 100.

rU=cov lus teb siab tshaj ntawm citicoline los ntawm cov qauv tshuaj.

rS=ncov cov lus teb ntawm citicoline los ntawm Standard tov.

CS=concentration ntawm USP Citicoline RS nyob rau hauv Standard tov (mg/mL).

CU=concentration ntawm Citicoline hauv cov tshuaj Sample (mg/mL).

Kev lees txais cov qauv: 98.0 feem pua ​​-102.0 feem pua ​​ntawm lub hauv paus qhuav

6 Chromatogram

7 Kev Tsim Nyog

Tom qab xyoo ntawm kev tsim khoom, peb lub tuam txhab tau txais daim ntawv tso cai tsim khoom tsim nyog.

8 Patent cov ntsiab lus

Tom qab ntau xyoo ntawm kev ua haujlwm nyuaj, Kono Chem Co., Ltd tau txais ntau cov patented technologies.

Hauv qab no yog tus lej patent:

PIB CN113527166A

CN112934445A

CN213006706U

CN212731128U

CN212576285U

CN212467595U

CN212467207U

PIB CN112961024A

9 Tus khub

Peb muaj ntau tus neeg koom tes mus sij hawm ntev thoob plaws ntiaj teb.

10 Cov neeg siv khoom xyuas

Peb tau txais kev qhuas ntau ntawm lwm lub platform, thiab peb cov neeg siv khoom tau zoo siab heev ntawm cov khoom tsim los ntawm peb lub tuam txhab.

11 Chav kuaj thiab lub Hoobkas ib puag ncig

12 Exhibition

Peb lub tuam txhab koom nrog ntau yam kev nthuav qhia hauv tsev thiab txawv teb chaws txhua xyoo, thiab sib txuas lus nrog cov neeg siv khoom ntsej muag.

Cim npe nrov: citicoline hmoov 987-78-0, manufacturers, lwm tus neeg, Hoobkas, lag luam wholesale, yuav, nqe, zoo tshaj plaws, tej, kev muag khoom